Chiral capillary electrophoresis–electrospray mass spectrometry coupling using vancomycin as chiral selector

Considerations concerning interaction characterization of oligopeptide mixtures with vancomycin using affinity capillary electrophoresis-electrospray mass spectrometry

“…The presence of vancomycin in the MS ion source also decreases sensitivity because of the competition with the peptides for the available charges as well as due to the increase of the background noise [43].…”

Separation of etodolac enantiomers by capillary electrophoresis. Validation and application of the chiral method to the analysis of commercial formulations

“…However, until now, very few methods for the baseline separation of etodolac enantiomers have been reported. Using vancomycin as chiral selector, Fanali et al [17] achieved the separation of the enantiomers of etodolac in about 12 min and detected them by mass spectrometry with electrospray ionization. Vancomycin is a glycopeptide-type macrocyclic antibiotic with a limited pH working range (4 , pH , 8), adsorbs to the wall of untreated fused-silica capillaries and has strong absorption in the UV-Vis region.…”

Evaluation of quail egg white riboflavin binding protein as a chiral selector in capillary electrophoresis by applying a modified partial filling technique

“…This system may also be set up with other selectors that elicit a strong detector response, such as macrocyclic antibiotics [15±17], cyclodextrins [18], and sodium dodecyl sulfate [19]; however, it was first developed for protein-based separations since proteins cause the worst problems. The attractive features of the technique are mainly the ability to use much higher selector concentrations than in the CFT [20±24], higher efficiencies, low consumption of material, and compatibility with the mass spectrometer interface [19,25,26].…”