2022
DOI: 10.1002/adhm.202201032
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Chiral Hydrogel Accelerates Re‐Epithelization in Chronic Wounds via Mechanoregulation

Abstract: Chronic wounds, such as diabetic foot ulcers (DFU), are a serious clinical problem. It is a challenge for the conventional wound dressings to achieve the desirable therapeutic efficacy due to the lack of biomimetic structural environment for rapid re-epithelization. Inspired by the naturally existing chiral structures in skin, a novel amino acid-based chiral hydrogel dressing is developed, consisting of left-handed or right-handed helical fibers self-assembled by l/d-phenylalanine derivatives. Compared to the … Show more

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Cited by 31 publications
(23 citation statements)
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“…In this nano era, more and more “top-down” and “bottom-up” techniques are developed for bioengineering and biotechnology, accompanied with a series of novel functional materials such as hydrogels and new types of polymers ( Li et al, 2022b ; Zhang et al, 2022b ; Wang et al, 2022c ; Wang et al, 2022d Song et al, 2022 ; Wang and Feng, 2022 ; Zhu et al, 2022 ) and even inorganic nanoparticles ( Tang et al, 2022b ; Chen et al, 2022c ; Wu et al, 2022 ). The present protocols showed a frontier, in which the combination of a top-down electrospinning and a bottom-up of molecular self-emulsifying was explored to fabricate biomedical materials for resolving one of the most difficult challenges, i.e.…”
Section: Resultsmentioning
confidence: 99%
“…In this nano era, more and more “top-down” and “bottom-up” techniques are developed for bioengineering and biotechnology, accompanied with a series of novel functional materials such as hydrogels and new types of polymers ( Li et al, 2022b ; Zhang et al, 2022b ; Wang et al, 2022c ; Wang et al, 2022d Song et al, 2022 ; Wang and Feng, 2022 ; Zhu et al, 2022 ) and even inorganic nanoparticles ( Tang et al, 2022b ; Chen et al, 2022c ; Wu et al, 2022 ). The present protocols showed a frontier, in which the combination of a top-down electrospinning and a bottom-up of molecular self-emulsifying was explored to fabricate biomedical materials for resolving one of the most difficult challenges, i.e.…”
Section: Resultsmentioning
confidence: 99%
“…By HSL conversion of the response color of 1–15 mmol/L, the color phase angle of each color was obtained, and its angle value was linearly fit, yielding R 2 = 0.96707 ( Figure 9 c), which already includes the human blood glucose concentration range (3.9–6.1 mmol/L), meeting the needs for simple testing of human blood glucose. Today, new kinds of polymers [ 80 , 81 , 89 ], organic and inorganic nanoparticles [ 90 , 91 ], and novel strategies for biomedical applications [ 92 , 93 , 94 , 95 , 96 , 97 ] are continuously reported. These achievements can be borrowed into the design and development of electrospun nanofibers, and thus promote new kinds of sensors and biomedical devices.…”
Section: Resultsmentioning
confidence: 99%
“…Electrospun porous nanofibers have become a research hotspot, so with the progress and development of electrospinning technology and the unremitting efforts of scientists and researchers, more excellent performances of electrospun porous nanofibers can be developed. The expansion of their applications can be further strengthened along with the fast developments in modern science and technology, such as encapsulating new functional ingredients [ 182 , 183 , 184 ] and additives [ 185 , 186 ], exploring new types of filament-forming polymeric matrices [ 187 , 188 ], being introduced to popular life-improving applications [ 189 , 190 , 191 , 192 , 193 , 194 ], taking advantage of new strategies of synthesizing materials [ 195 , 196 ], and drawing support from traditional techniques for production on a large scale [ 197 , 198 ].…”
Section: Discussionmentioning
confidence: 99%