Chiral recognition of tryptophan enantiomer based on the electrode modified by polyaniline adsorption bovine serum albumin complex

Yao, Wenyan; Li, Sha; Xie, Licheng; Jiang, Yan

doi:10.1002/chir.23525

Cited by 6 publications

(1 citation statement)

References 53 publications

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“…Moreover, the surface of BSA is rich in various functional groups, such as amino and carboxyl [33], which can be easily combined with different substances through different forces. For example, see Yao et al [34]. conjugation of ammonium persulfate-doped polyaniline to BSA, which recognizes tryptophan enantiomers, the peak current ratio is 1.95.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Three–Dimensional Graphene Containing Chitosan and Bovine Serum Albumin for Recognizing Chiral Drug Intermediates

Yao

Xie

et al. 2023

Chemosensors

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Chiral enantiomer recognition has important research significance in the field of analytical chemistry research. At present, most prepared chiral sensors are used for recognizing amino acids, while they are rarely used in the identification of drug intermediates. This work found that combining CS and reduced graphene oxide can enhance conductivity, increasing the recognition effect by connecting CS with BSA. Based on the above preparation, a new type of chiral sensor (3D−rGO−CS−BSA) was synthesized for the identification of drug intermediates, including the 1−Boc−3−hydroxypyrrolidine enantiomer. An obvious difference was achieved (IR/IS = 2.82) in the oxidation peak currents between the two enantiomers. The detection limits of the R−enantiomer and S−enantiomer were 4.85 nM and 11.76 nM, respectively. The proposed electrochemical sensing platform also has better potential for detecting the percentage content of mixed chiral enantiomer drugs.

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Section: Introductionmentioning

confidence: 99%

Functionalized Three–Dimensional Graphene Containing Chitosan and Bovine Serum Albumin for Recognizing Chiral Drug Intermediates

Yao

Xie

et al. 2023

Chemosensors

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Chiral Materials: Progress, Applications, and Prospects

Niu

Zhao

Yan

et al. 2023

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Chirality is a universal phenomenon in molecular and biological systems, denoting an asymmetric configurational property where an object cannot be superimposed onto its mirror image by any kind of translation or rotation, which is ubiquitous on the scale from neutrinos to spiral galaxies. Chirality plays a very important role in the life system. Many biological molecules in the life body show chirality, such as the “codebook” of the earth's biological diversity‐DNA, nucleic acid, etc. Intriguingly, living organisms hierarchically consist of homochiral building blocks, for example, l‐amino acids and d‐sugars with unknown reason. When molecules with chirality interact with these chiral factors, only one conformation favors the positive development of life, that is, the chiral host environment can only selectively interact with chiral molecules of one of the conformations. The differences in chiral interactions are often manifested by chiral recognition, mutual matching, and interactions with chiral molecules, which means that the stereoselectivity of chiral molecules can produce changes in pharmacodynamics and pathology. Here, the latest investigations are summarized including the construction and applications of chiral materials based on natural small molecules as chiral source, natural biomacromolecules as chiral sources, and the material synthesized by design as a chiral source.

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Anthracene-bridged “Texas-sized” box for the simultaneous detection and uptake of tryptophan

Luo,

Tian,

Zhou

et al. 2024

Chinese Chemical Letters

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Chiral recognition of tryptophan enantiomer based on the electrode modified by polyaniline adsorption bovine serum albumin complex

Cited by 6 publications

References 53 publications

Functionalized Three–Dimensional Graphene Containing Chitosan and Bovine Serum Albumin for Recognizing Chiral Drug Intermediates

Functionalized Three–Dimensional Graphene Containing Chitosan and Bovine Serum Albumin for Recognizing Chiral Drug Intermediates

Chiral Materials: Progress, Applications, and Prospects

Anthracene-bridged “Texas-sized” box for the simultaneous detection and uptake of tryptophan

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