Chiral resolution of differently substituted racemic acetyl-1-phenyl ethanol using lipase from Bacillus subtilis

Bhushan, Indu; Kumar, Anil; Modi, Gourav; Jamwal, Subika

doi:10.1002/jctb.2483

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Transesterification using lipases from Pseudomonas allows for insecticides, fungicides and herbicides such as (S)-indanofan to be obtained, this is used to control wild grass and weeds [46]. Moreover, optically active forms of pesticides were synthesized using lipases from Bacillus subtilis for the resolution of racemic mixtures of carboxylic esters or alcohol [47]. Biodiesel is defined as mono-alkyl esters of long-chain fatty acids, which are usually methyl esters of fatty acids and are commonly denoted as fatty acid methyl esters (FAME), which are used as an alternative fuel that is non-toxic, non-inflammable, biodegradable and renewable.…”

Section: Functions and Applications Of Lipasesmentioning

confidence: 99%

Various Perspectives on Microbial Lipase Production Using Agri-Food Waste and Renewable Products

et al. 2021

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Lipases are enzymes that catalyze various types of reactions and have versatile applications. Additionally, lipases are the most widely used class of enzymes in biotechnology and organic chemistry. Lipases can be produced by a wide range of organisms including animals, plants and microorganisms. Microbial lipases are more stable, they have substrate specificity and a lower production cost as compared to other sources of these enzymes. Although commercially available lipases are widely used as biocatalysts, there are still many challenges concerning the production of microbial lipases with the use of renewable sources as the main component of microbial growth medium such as straw, bran, oil cakes and industrial effluents. Submerged fermentation (SmF) and solid-state fermentation (SSF) are the two important technologies for the production of lipases by microorganisms. Therefore, this review focuses on microbial lipases, especially their function, specificity, types and technology production, including the use of renewable agro-industrial residues and waste materials.

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Section: Functions and Applications Of Lipasesmentioning

confidence: 99%

Various Perspectives on Microbial Lipase Production Using Agri-Food Waste and Renewable Products

et al. 2021

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“…Particularly, one of the herbicides ( S )‐indanofan, which is used against wild grass and weeds, was proven to be successful . Also, optically active forms of pesticides were synthesized by employing lipase for the resolution of racemic mixtures of alcohol or carboxylic esters as reported for lipases from B. subtilis . Nikkomycin‐B, a potent biologically active pesticide was prepared through lipase‐catalyzed stereospecific synthesis .…”

Section: Applications Of Lipase‐catalyzed Reactionsmentioning

confidence: 99%

“…8 Also, optically active forms of pesticides were synthesized by employing lipase for the resolution of racemic mixtures of alcohol or carboxylic esters as reported for lipases from B. subtilis. 273 Nikkomycin-B, a potent biologically active pesticide was prepared through lipase-catalyzed stereospecific synthesis. 73 Interesting literature on the application of lipases in the field of agrochemicals can be found elsewhere.…”

Section: Agrochemicalsmentioning

confidence: 99%

Recent advances on sources and industrial applications of lipases

Sarmah

Revathi

Sheelu

et al. 2017

Biotechnology Progress

302

148

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Lipases are the industrially important biocatalysts, which are envisioned to have tremendous applications in the manufacture of a wide range of products. Their unique properties such as better stability, selectivity and substrate specificity position them as the most expansively used industrial enzymes. The research on production and applications of lipases is ever growing and there exists a need to have a latest review on the research findings of lipases. The present review aims at giving the latest and broadest overall picture of research and development on lipases by including the current studies and progressions not only in the diverse industrial application fields of lipases, but also with regard to its structure, classification and sources. Also, a special emphasis has been made on the aspects such as process optimization, modeling, and design that are very critical for further scale-up and industrial implementation. The detailed tabulations provided in each section, which are prepared by the exhaustive review of current literature covering the various aspects of lipase including its production and applications along with example case studies, will serve as the comprehensive source of current advancements in lipase research. This review will be very useful for the researchers from both industry as well as academia in promoting lipolysis as the most promising approaches to intensified, greener and sustainable processes. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:5-28, 2018.

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Chemical and enzymatic approaches to the synthesis of optically pure ethyl (R)-4-cyano-3-hydroxybutanoate

You

Liu

Zheng

2013

Appl Microbiol Biotechnol

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Ethyl (R)-4-cyano-3-hydroxybutanoate (HN) is an important chiral synthon for side chain of the cholesterol-lowering drug atorvastatin (Lipitor), which is the hydroxymethylglutaryl CoA reductase inhibitor. HN is also used as a synthon in the production of L-carnitine and (R)-4-amino-3-hydroxybutanoic acid. It is necessary to have a clear understanding of the synthesis process of HN for its extensive use. This review gives an overview of different synthetic strategies of optically active HN, including chemical and enzymatic approaches. The emphasis is focused mainly on the synthetic routes using biocatalysts, such as halohydrin dehalogenase, nitrilase, carbonyl reductase, and lipase.

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Chiral resolution of differently substituted racemic acetyl-1-phenyl ethanol using lipase from Bacillus subtilis

Cited by 5 publications

References 16 publications

Various Perspectives on Microbial Lipase Production Using Agri-Food Waste and Renewable Products

Various Perspectives on Microbial Lipase Production Using Agri-Food Waste and Renewable Products

Recent advances on sources and industrial applications of lipases

Chemical and enzymatic approaches to the synthesis of optically pure ethyl (R)-4-cyano-3-hydroxybutanoate

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