No abstract

In the present investigation a Lipase producing strain, Bacillus subtilis (MTCC-121) was grown on various media containing different sources of carbon, nitrogen and other nutrients. The best media found for the production of lipase was M2 media containing 0.4% peptone, 0.2% beef extract and 1% NaCl. Lipase produced from this culture was used for the kinetic resolution of racemic acetyl-1-phenyl ethanol and its derivatives, which are important as chiral auxiliaries and intermediates in the synthesis of natural products, pharmaceuticals and agrochemicals. The lipase resolved these substrates after 48 h with enantiomeric excess of 90-98% and conversion 40-48%.

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Interferon (IFN)-τ secreted only by ruminant endometrium, helps in maternal recognition of pregnancy and exhibit antiviral and antiproliferative activity. Among different types of IFN-τ, IFN-τ1c and IFN- τ3a are the most highly expressed isoforms. In the present study structure of INF-τ1c was predicted using homology modelling. The best model was selected based on overall stereo-chemical quality. The generated 3D structure of the Interferon-τ1c protein of Bos taurus was predicted using the ovine interferon-τ (PDB ID: 1B5L_A) as template. The structure comprises of 5 α helices separated by loop regions, which is similar to the one predicted for other IFNs. Molecular interactions of bovine IFN-τ1c with human interferon Type 1 receptor (IFNAR1) was explored in an attempt to predict human IFNAR1 binding sites of IFN-τ1c.