Chiral resolution of phenylalanine by d-Phe imprinted membrane considering rejection property

Abstract

An enantio-selective D-Phe imprinted P(AA-co-AN) membrane was prepared using the wet-phase inversion method. The membrane not only selectively adsorbed phenylalanine but also rejected it with a rejection selectivity of 0.82-0.64 and 0.91-0.63 during the filtration of 100 and 10 ppm (g m(-3)) racemate solutions, respectively. The fluxes of D-Phe and L-Phe during filtration of 10 ppm racemate solution were 0.0077-0.0229 and 0.0064-0.0208 mg m(-2) s(-1), respectively, and the fluxes of D-Phe and L-Phe during filtration of 100 ppm racemate solution were 0.1287-0.2522 and 0.1174-0.2458 mg m(-2) s(-1), respectively. The adsorption selectivity was higher at low concentration. The adsorption selectivities varied from 1.11 to 1.65 and from 1.64 to 2.78 during filtration of 100 and 10 ppm racemate solutions, respectively. In respect to desorption, the fractional difference between D-Phe and L-Phe in the recovered solution from 10 ppm was higher than that from 100 ppm.

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

“…The majority of reported molecularly imprinted membrane studies has as an ultimate goal, either process development (in particular for separation and purification) or incorporation with sensors . While efforts to develop and apply molecularly imprinted membranes continue, it remains clear that more work is required to address the mechanisms underlying membrane function.…”

Molecularly Imprinted Membranes

“…In 2010 [73], the same author proposed another enantioselective D -Phe imprinted P(AA-co-AN) membrane prepared by phase inversion precipitation. The membrane selectively adsorbed template enantiomer over the other enantiomer and adsorption selectivity was higher at low solute concentrations and had a rejection selectivity of 0.82–0.64 and 0.91–0.63 for the filtration of 100 and 10 ppm racemic solutions.…”

Chiral Templating of Polycarbonate Membranes by Pinene Using the Modified Atomic Layer Deposition Approach

“…Thus, materials with a primary and/or secondary chiral structure (e.g. helix) such as ((poly(triphenylmethyl methacrylate)), polysaccharides, 14,15 proteins, cyclodextrins, [16][17][18][19] and imprinted polymers 20,21 have been used to prepare chiral membranes by direct synthesis or for a modification of achiral membranes. Another approach is based on the incorporation of chiral selectors into a micro-porous solid, e.g.…”