Chitin and its derivatives: Structural properties and biomedical applications

Ahmad, Shahnawaz; Ahmad, Razi; Khan, Mohd. Shahid; Kant, Ravi; Shahid, Shumaila; Gautam, Leela; Hasan, Gulam Mustafa; Hassan, Md. Imtaiyaz

doi:10.1016/j.ijbiomac.2020.07.098

Cited by 148 publications

(58 citation statements)

References 198 publications

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“…The weaker hydrogen-bonding of the parallel-chain structure of β-chitin may account for its higher chemical reactivity. In addition, β-chitin has the unique feature of incorporating small molecules, including water, into its crystal lattice to form crystalline complexes [ 27 , 28 ]. The unique structure of intramolecular hydrogen bonds might facilitate the combination of the active components of the culture medium to form a gel.…”

Section: Discussionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel promote wound healing in rats

Liu

et al. 2022

J Mater Sci: Mater Med

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Because of stem cells are limited by the low efficiency of their cell homing and survival in vivo, cell delivery systems and scaffolds have attracted a great deal of attention for stem cells’ successful clinical practice. β-chitin nanofibers (β-ChNF) were prepared from squid pens in this study. Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy proved that β-ChNFs with the diameter of 5 to 10 nm were prepared. β-ChNF dispersion became gelled upon the addition of cell culture medium. Cell culture experiments showed that β-ChNFs exhibited negligible cytotoxicity towards ADSCs and L929 cells, and it was found that more exosomes were secreted by the globular ADSCs grown in the β-ChNF hydrogel. The vivo experiments of rats showed that the ADSCs-loaded β-ChNF hydrogel could directly cover the wound surface and significantly accelerate the wound healing and promote the generation of epithelization, granulation tissue and collagen. In addition, the ADSCs-loaded β-ChNF hydrogel clearly regulated the expressions of VEGFR, α-SMA, collagen I and collagen III. Finally, we showed that ADSCs-loaded β-ChNF hydrogel activated the TGFβ/smad signaling. The neutralization of TGFβ markedly reduced Smad phosphorylation and the expressions of TIMP1, VEGFR and α-SMA. Taken together, these findings suggest that ADSCs-loaded β-ChNF hydrogel promises for treating wounds that are challenge to heal via conventional methods.

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Section: Discussionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel promote wound healing in rats

Liu

et al. 2022

J Mater Sci: Mater Med

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“…Chitin can be degraded in vivo and has high affinity with multiple cells. Thus, chitin has been widely used as a vital biomaterial in the field of tissue engineering [35]. In this study, chitosan was used as the raw material for the nerve conduits.…”

Section: Discussionmentioning

confidence: 99%

Chitin Nerve Conduits with Three-Dimensional Spheroids of Mesenchymal Stem Cells from SD Rats Promote Peripheral Nerve Regeneration

Zhang

Liu

et al. 2021

Polymers

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Peripheral nerve injury (PNI) is an unresolved medical problem with limited therapeutic effects. Epineurium neurorrhaphy is an important method for treating PNI in clinical application, but it is accompanied by inevitable complications such as the misconnection of nerve fibers and neuroma formation. Conduits small gap tubulization has been proved to be an effective suture method to replace the epineurium neurorrhaphy. In this study, we demonstrated a method for constructing peripheral nerve conduits based on the principle of chitosan acetylation. In addition, the micromorphology, mechanical properties and biocompatibility of the chitin nerve conduits formed by chitosan acetylation were further tested. The results showed chitin was a high-quality biological material for constructing nerve conduits. Previous reports have demonstrated that mesenchymal stem cells culture as spheroids can improve the therapeutic potential. In the present study, we used a hanging drop protocol to prepare bone marrow mesenchymal stem cell (BMSCs) spheroids. Meanwhile, spherical stem cells could express higher stemness-related genes. In the PNI rat model with small gap tubulization, BMSCs spheres exhibited a higher ability to improve sciatic nerve regeneration than BMSCs suspension. Chitin nerve conduits with BMSCs spheroids provide a promising therapy option for peripheral nerve regeneration.

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“…Chitin is vital and renewable natural resource (Agboh and Qin, 1997;Ma et al, 2020). Exoskeleton extracted chitin and its derivatives have a wide range of applications due to its biocompatibility (Barikani et al, 2014), biodegradability (Zhu et al, 2019), antimicrobial and antioxidative properties (Ahmad et al, 2020) and reactivity (Younes and Rinaudo, 2015). However, its sources still disposed in the environment in large quantities (Kumar et al, 2018).…”

Section: Growth Biochemical Parametersmentioning

confidence: 99%

Effect of shrimp waste extracted chitin on growth and some biochemical parameters of the Nile tilapia

El-Serafy¹,

Abdel-Hameid²,

Abdel-Salam³

et al. 2021

Egypt. J. of Aquatic Biolo. and Fish.

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Capture fisheries is the utilization of the usable aquatic organisms by the public with or without permissions (El-Sayed, 2006). Aquaculture is the farming of marine and freshwater organisms under controlled conditions. It is a highly growing food production sector (Ahmed and Thompson, 2019). Its global production of fish in 2018 was approximately 179 million tons (FAO, 2020). Farmed Fish are a chief source of food for poor people (Stead, 2019). It is a cheap form of animal protein (Nölle et al., 2020). Due to overfishing, fisheries stock worldwide is largely exploited. As the aquaculture become the main source to cope the fish demand, there is an awareness to increase its productivity with the increase of human population (Tidwell and Allan, 2001; Gephart et al., 2020). Tilapia is regarded as the second most farmed fish all-over the world ARTICLE INFO

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Chitin and its derivatives: Structural properties and biomedical applications

Cited by 148 publications

References 198 publications

Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel promote wound healing in rats

Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel promote wound healing in rats

Chitin Nerve Conduits with Three-Dimensional Spheroids of Mesenchymal Stem Cells from SD Rats Promote Peripheral Nerve Regeneration

Effect of shrimp waste extracted chitin on growth and some biochemical parameters of the Nile tilapia

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