Chitosan: a New Versatile Bio-polymer for Various Applications

Sahoo, Debasish; Sahoo, Sarmila; Mohanty, Priyanka; Sasmal, Supriya; Nayak, Padma L.

doi:10.1163/138577209x12486896623418

Cited by 117 publications

(55 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue, cell or intracellular compartment, the control over release kinetics, the protection of the active agent or a combination of the above. Polymer composites were proposed as drug carriers over 30 years ago and have received growing attention since, mainly due to their stability, enhanced loading capabilities and control over physicochemical properties [1][2]. In addition to systemic administration, localized drug release may be achieved using macroscopic drug depots close to the target site.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin

Parida¹,

Nayak²,

Binhani³

et al. 2011

JBNB

Self Cite

126

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin

Parida¹,

Nayak²,

Binhani³

et al. 2011

JBNB

Self Cite

126

View full text Add to dashboard Cite

show abstract

“…Flutamide is a synthetic, non-steroidal, pure antiandrogen used primarily to treat prostate cancer (Sahoo et al, 2009). It acts as a silent antagonist of the androgen receptor (AR), competing with androgens such as testosterone and its powerful active metabolite dihydrotestosterone (DHT) for binding to ARs in the prostate gland.…”

Section: Chemical Structure Sodium Alginatementioning

confidence: 99%

“…In recent years, biodegradable polymers have attracted attention to be used as biomaterials particularly, for tissue engineering, gene therapy, wound healing and controlled drug delivery systems (Sahoo et al, 2009). The most important advantage of biodegradable polymers is the disappearance of implanted foreign materials from the body as a result of their biodegradation.…”

Section: Introductionmentioning

confidence: 99%

Interpenetrating Polymer Network Hydrogel Membranes of Karayagum and Sodium Alginate for Control Release of Flutamide Drug

Nagarjuna¹,

Babu²,

Maruthi³

et al. 2016

J App Pharm Sci

View full text Add to dashboard Cite

Flutamide (FLT) is a potent non-steroidal antiandrogen drug primarily used in palliative treatment of prostate cancer that inhibits androgen uptake and / or nuclear binding of androgen in target tissue. The present study gives, the experimental results on the successful encapsulation of Flutamide drug using Sodium Alginate (SA)/ Karaya gum (KG)) blend hydrogel membranes as controlled release (CR) polymer matrices. The Flutamidecontaining polymer blend hydrogel membranes have been prepared by changing the experimental variables such as KG, SA and drug content by solution casting evaporation method. The membranes were characterized by swelling studies, FTIR, DSC, XRD, and SEM studies. The swelling results indicated that swelling of polymer membranes decrease with the increasing the amounts of Karaya gum. However, no significant variation in swelling was observed with different amounts of flutamide loading. The absence of chemical interactions between active ingredients and polymer was confirmed by FT-IR spectral measurements. Differential scanning calorimeter (DSC) and X-ray diffraction (XRD) studies were performed to understand the crystalline nature of drug after encapsulation into the Hydrogel membranes. Scanning electron microscopy (SEM) was used to study the surface morphology of the hydrogel membranes. The in vitro studies were carried out in phosphate buffer pH 7.4 at 37 o C. The results of controlled release tests showed that the amount of Flutamide release increased with the increasing the amount of SA in the membrane. Moreover, the release rate of drug increased as the amount of drug loaded in the membranes increased. All the results indicated that the prepared membrane was potentially useful in drug delivery systems and the prolonged release rate was observed. Key words:Interpenetrating Polymer Network, Flutamide, Encapsulation, Karaya Gum. INTRODUCTIONIn recent years, biodegradable polymers have attracted attention to be used as biomaterials particularly, for tissue engineering, gene therapy, wound healing and controlled drug delivery systems (Sahoo et al., 2009). The most important advantage of biodegradable polymers is the disappearance of implanted foreign materials from the body as a result of their biodegradation. In general polymers used in biomedical * Corresponding Author E-mail: chowdojirao @ gmail.com applications are poly (lactic acid), poly(glycolic acid) (PGA), poly(e-caprolactone) (PCL), poly(3-hydroxyl butyrate) (PHB), copolymers of polyglycolide, chitosan, alginate and natural gums such as Xanthan Gum, Guar gum (Sahoo et al., 2010; Edulund et al., 2002;Jain Rajeev et al., 2002;Kamath et al., 1993).Different types of drug delivery systems, like microcapsules, microspheres, implants, pallets and hydrogel membranes have been fabricated by using above bio-degradable polymers as drug matrix. Hydrogel membranes play a major role in medical applications, in particular in a number of life saving treatment methods. Membranes are used in drug delivery, artificial organs, tissue regeneration,...

show abstract

“…During the past two decades, biodegradable polymers have attracted attention research to be developed as biomaterials, carriers of immobilized enzyme and cell, biosensor, for tissue engineering, materials for orthopedic and controlled drug delivery system [1][2][3][4][5][6][7][8]. Natural polymers have potential pharmaceutical applications because of low toxicity, biocompatibility and biodegradable characteristic [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug

Cahyaningrum¹,

Herdyastuti²,

Qomariah³

2015

Indones. J. Chem.

View full text Add to dashboard Cite

show abstract

Chitosan: a New Versatile Bio-polymer for Various Applications

Cited by 117 publications

References 158 publications

Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin

Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin

Interpenetrating Polymer Network Hydrogel Membranes of Karayagum and Sodium Alginate for Control Release of Flutamide Drug

Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug

Contact Info

Product

Resources

About