Chitosan: A Promising Biomaterial for Tissue Engineering Scaffolds

Dutta, Parikshit; Rinki, Kumari; Dutta, Joydeep

doi:10.1007/12_2011_112

Cited by 55 publications

(34 citation statements)

References 122 publications

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“…Chitin is the second most abundant polysaccharide on earth after cellulose . They are linear copolymers of 2‐amino‐2‐deoxy‐D‐glucopyranose (GlcN or D units) and 2‐acetamido‐2‐deoxy‐D‐glucopyranose units (GlcAc or A units) joined together by β (1 → 4) glycosidic linkages.…”

Section: Chitosanmentioning

confidence: 99%

“…Free amino groups generated during chitin deacetylation not only allow the polymer to dissolve in aqueous medium but also participate in chemical modifications . Chitosan has been processed into 3D porous structures, hydrogels, and as a two‐dimensional film for variety of tissue healing and drug delivery application . The following few examples show the application of CN and its derivatives for tissue engineering and drug delivery applications.…”

Section: Chitosanmentioning

confidence: 99%

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Polysaccharide biomaterials for drug delivery and regenerative engineering

Shelke

James

Laurencin

et al. 2014

Polymers for Advanced Techs

255

148

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Polymers derived from plant (polysaccharides) and animal (proteins) kingdoms have been widely used for a variety of biomedical applications including drug delivery and tissue regeneration. These polymers due to their biochemical similarity with human extracellular matrix components are readily recognized and accepted by the body. Natural polymers inherit numerous advantages including natural abundance, relative ease of isolation, and room for chemical modification to meet varying technological needs. In addition, these polymers undergo enzymatic and/or hydrolytic degradation in biologic environments into non-toxic degradation byproducts. Polysaccharides (carbohydrates) are often isolated and purified from renewable sources including plants, animals, and microorganisms. Majority of these polymers are found in the extracellular matrix components of organisms and participate in inter and intracellular cell signaling and contribute to their growth. All these features offer polysaccharide-based biomaterials much desired biological recognition, biocompatibility, and bioactivity. In spite of many merits as biomaterials, these polysaccharides suffer from drawbacks including variations in material properties based on source, microbial contamination, uncontrolled water uptake, poor mechanical strength, and unpredictable degradation patterns. These inconsistencies have limited the usage of polysaccharides and biomedical application related technology development. Many of these polysaccharides have been chemically modified to achieve consistent physicochemical properties including mechanical stability, degradation, and bioactivity and processed into microparticles, hydrogels, and 3D porous structures for tissue regeneration applications. Presence of multiple functionalities on the polymer backbone allows easy structure modifications for the required application. The current article focuses on the application of polysaccharide-based materials in regenerative engineering and delivery.

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Section: Chitosanmentioning

confidence: 99%

Section: Chitosanmentioning

confidence: 99%

Polysaccharide biomaterials for drug delivery and regenerative engineering

Shelke

James

Laurencin

et al. 2014

Polymers for Advanced Techs

255

148

View full text Add to dashboard Cite

show abstract

“…The unique characteristics of chitosan like acts as replacement for missing or damaged tissue [41] and supporting cell attachment and proliferation will make suitable for tissue engineering applications [42]. Chitosan has favourable conditions like low immuno-genic activity, controlled biodegradability and porous structure for tissue engineering applications.…”

Section: Chitosan With Drug Formulations In Tissue Engineering Applicmentioning

confidence: 99%

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

Kashyap

Archana

Semwal³

et al. 2015

Springer Series on Polymer and Composite Materials

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Chitosan plays a most important role in the regenerative medication for wound healing. The adhesive nature of chitosan, with their antifungal and bactericidal character, and their permeability to oxygen, is a very important property associated with the treatment of wounds. Different derivatives and combination of chitosan have been reported for this purpose in the form of hydrogels, fibers, membranes, scaffolds and sponges. The purpose of the chapter is to have a closer look in the work done directly by different researchers on the chitosan formulation with potential medicinal applications to provide a better understanding of its usability in regenerative medicine.

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“…It has attracted significant interest by a lot of scientists due to its biological properties such as antitumor activity, antimicrobial activity and immune enhancing effect [3,4].…”

Section: Introductionmentioning

confidence: 99%

A GREEN AND SIMPLE SYNTHESIS OF CHITOSAN/Ag NANOCOMPOSITES AND STUDY FOR THEIR ANTIBACTERIAL ACTIVITY ON STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI

Quyên¹

2018

JST

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A green and simple approach has been successfully developed to synthesize chitosan/Ag nanocomposites using kumquat extract as a biological reducing agent. It indicates to be an ecofriendly and green method for the synthesis providing a cost effective and an efficient route for the chitosan/Ag nanocomposites' synthesis. The prepared chitosan/Ag nanocomposites have been characterized by UV-vis, TEM, FTIR, and XRD. Result showed those chitosan/Ag nanocomposites have been obtained with average particle size ~15-25 nm. Moreover, the synthesized chitosan/Ag nanocomposites also showed their efficient antimicrobial activity against S. aureus and E. coli. The chitosan/Ag nanocomposite was found to have significantly higher antimicrobial activity than its components at their respective concentrations. The presence of a small percentage (2.5 %, w/w) of metal nanoparticles in the nanocomposite was enough to significantly enhance inactivation of S. aureus and E. coli as compared with unaltered chitosan. Thus, this eco-friendly method could be a competitive alternative to the conventional physical/chemical methods used for the synthesis of chitosan/Ag nanocomposites. Since, it has a potential to use in biomedical and cosmetic applications.

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Chitosan: A Promising Biomaterial for Tissue Engineering Scaffolds

Cited by 55 publications

References 122 publications

Polysaccharide biomaterials for drug delivery and regenerative engineering

Polysaccharide biomaterials for drug delivery and regenerative engineering

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

A GREEN AND SIMPLE SYNTHESIS OF CHITOSAN/Ag NANOCOMPOSITES AND STUDY FOR THEIR ANTIBACTERIAL ACTIVITY ON STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI

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