Chitosan-coated cerium oxide nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation

Huang, Xue; Li, Lin-Dong; Lyu, Guang-Ming; Shen, Bai-Yu; Han, Yanfei; Shi, Jing‐Shan; Teng, Jia-Li; Li, Feng; Si, Shihui; Wu, Jun; Liu, Yanjun; Sun, Lei; Yan, Chun‐Hua

doi:10.1039/c7qi00707h

Cited by 77 publications

(41 citation statements)

References 36 publications

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“…The presence of a polymer gel in cerium dioxide nanoparticles with changing valency in the wound ensures the environment required for regeneration as a result of its anti-inflammatory, antioxidant, antimicrobial, and proregenerative effects. The decrease in the active forms of oxygen can be judged by the decrease in the number of non-resident cells (leukocytes), which are the main producers of free radicals in the wound, which is consistent with the conclusions from different groups of scientists [39][40][41]. The positive effects of CeO 2 that are relevant for regenerative medicine are consistent with the results of other studies [19][20][21][22][23][24]27,42].…”

Section: Discussionsupporting

confidence: 90%

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

et al. 2020

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High-quality and aesthetic wound healing, as well as effective medical support of this process, continue to be relevant. This study aims to evaluate the medical efficacy of a novel smart polymeric nanodrug (SPN) on the rate and mechanism of wound healing in experimental animals. The study was carried out in male Wistar rats (aged 8–9 months). In these animals, identical square wounds down to the fascia were made in non-sterile conditions on the back on both sides of the vertebra. SPN was used for the treatment of one wound, and the other wound was left without treatment (control group). Biocompatible citrate-stabilized cerium oxide nanoparticles integrated into a polysaccharide hydrogel matrix containing natural and synthetic polysaccharide polymers (pectin, alginate, chitosan, agar-agar, water-soluble cellulose derivatives) were used as the therapeutic agent. Changes in the wound sizes (area, volume) over time and wound temperature were assessed on Days 0, 1, 3, 5, 7, and 14. Histological examination of the wounds was performed on Days 3, 7, and 14. The study showed that the use of SPN accelerated wound healing in comparison with control wounds by inhibiting the inflammatory response, which was measured by a decreased number of white blood cells in SPN-treated wounds. It also accelerated the development of fibroblasts, with an early onset of new collagen synthesis, which eventually led to the formation of more tender postoperative scars. Thus, the study demonstrated that the use of SPN for the treatment of wounds was effective and promising.

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Section: Discussionsupporting

confidence: 90%

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

et al. 2020

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“…There are also promising fields like anticancer and cutaneous wound healing, which all need to be explored in the future. For example, the biodegradable material chitosan can function synergistically with CeO 2 NPs to improve the biocompatibility and expedite the wound healing process [79]. It is quite necessary to input more efforts for the development of this potential and excellent material in the future.…”

Section: Synergistic Actions Of Ceo 2 Nps With Other Materialsmentioning

confidence: 99%

Antibacterial mechanism and activity of cerium oxide nanoparticles

et al. 2019

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Nanomaterials have been applied as antibacterial agents by virtue of their unique functioning mechanism different from that of conventional antibiotics. Cerium oxide nanoparticles (CeO 2 NPs) are important antibacterial agents due to their relatively low toxicity to normal cells and their distinct antibacterial mechanism based on the reversible conversion between two valence states of Ce(III)/ Ce(IV). Some studies have been conducted to explore their antibacterial activities; however, systematic research reviews on the related mechanisms and influencing factors are still quite rare. In this review, we discuss the plausible mechanisms of the antibacterial activity of CeO 2 NPs, analyze different influencing factors, and summarize various research reports on antibacterial effects on E. coli and S. aureus. We also propose the potential applications and prospects, and hope to provide an in-depth understanding on the antibacterial mechanism and a better guidance to the design and applications of this promising antibacterial material in the future.

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“…To date, several CNP-containing materials, including polymeric constructs, ceramics, and different composites, have been proven to have extensive potential for wound healing [ 71 , 108 , 109 ]. For example, nanoceria-functionalized polycaprolactone-gelatin electrospun nanofibers were prepared and used to enhance wound healing.…”

Section: Nanoceria For Soft-tissue Engineeringmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Chitosan-coated cerium oxide nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation

Abstract: Chitosan-coated ceria nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation with powerful anti-inflammation and anti-oxidation properties.

Cited by 77 publications

References 36 publications

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

Antibacterial mechanism and activity of cerium oxide nanoparticles

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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