Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect

Abstract

16The choice of drug therapy in pregnant patients suffering from vaginal infections is limited 17 by the safety profile of the drug. Assuring the efficient topical therapy to avoid systemic 18 absorption is considered the best therapy option. Chitosan-coated liposomes have been 19 developed and optimized to assure localized therapy of clotrimazole. Chitosan was selected 20 as mucoadhesive polymer both to prolong system's retention at the vaginal site and act on 21 biofilms responsible for high recurrence of infections. Sonicated liposomes were coated 22 with chitosan in three different concentrations, namely 0.1, 0.3 and 0.6 % (w/v).

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

“…Mean vesicle diameter and polydispersity index (PI) of the different liposome formulations was determined by photon correlation spectroscopy (PCS) with a Submicron Particle Sizer Model 370 (Nicomp Particle Sizing Systems, Santa Barbara, USA) as described earlier (di Cagno et al, 2011, Jøraholmen et al, 2014 with minor modifications. All sample tubes were sonicated in PBS pH 7.4 for 10 minutes prior to use, to eliminate any dust particles.…”

New strategies for local treatment of vaginal infections

“…Limited stability in aqueous formulations represents one of their major drawbacks [154]. Concerning the treatment of vaginal infections, several works have been done studying liposomes for the formulation of antifungals [154,[172][173][174] and antibacterials [172,175] …”

“…Loaded liposomes were shown to exhibit antifungal activity against C. albicans[177].Meanwhile, specific liposome formulations have been designed to gain improved mucoadhesive properties. Coating of liposomes with low MW chitosan has been shown to reduce clotrimazole penetration through the vaginal tissue while improving retention in the target site of action and assuring prolonged release of the drug[173]. Liposomes coated with chitosan solution were shown to be associated with lowest clotrimazole penetration and highest retention in sheep vaginal tissue when compared to clotrimazol solution.…”

Groundnut oil based emulsion gels for passive and iontophoretic delivery of therapeutics

“…Balata et al [5] investigated propolis organogel as a novel topical delivery system for treating wounds. Topical delivery systems are employed not only to treat skin related problems, but also for complications associated with eyes, [6] nose, [7], vagina [8], or rectum [9] etc. where patients compliance and satisfaction are essential.…”