Chitosan-coated silica gel as a new support in high-performance liquid chromatography

Carunchio, V.; Girelli, Anna Maria; Messina, A.; Sinibaldi, M.

doi:10.1007/bf02312665

Cited by 15 publications

(7 citation statements)

References 10 publications

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“…As mentioned previously, the presence of positively charged moieties on a polysaccharide chain should favour its interaction with silica nanoparticles through attractive electrostatic interactions. In this context, a large number of works have described the association of silica with chitosan, firstly in the context of the design of chromatography stationary phases84 and, later on, for the development of biomaterials 85…”

Section: Bionanocomposites From Silica Particlesmentioning

confidence: 99%

Understanding and Tuning Bioinorganic Interfaces for the Design of Bionanocomposites

2015

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International audienceInteractions between biological molecules and inorganic species are of tremendous importance in nature. Attempts to create bionanocomposites associating nanoscale inorganic objects with biomolecules face major challenges with regard to controlling their mutual reactivity and preserving their intrinsic properties. This review describes the interactions arising between polyoxometallates or silica particles and biomolecules - including proteins, polysaccharides, lipids and nucleic acids - that depend on physicochemical conditions. It shows that chemical modification of the inorganic and/or bio-organic partner allows fine-tuning of their interface. The specific properties of these bionanocomposites are illustrated, with emphasis on their potential in biotechnology and biomedicine. This field contributes to a better understanding of the ``biochemistry of solids'' and offers an almost unlimited playground for the elaboration of new materials that combine molecular biodiversity with chemistry in its many facets

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Section: Bionanocomposites From Silica Particlesmentioning

confidence: 99%

Understanding and Tuning Bioinorganic Interfaces for the Design of Bionanocomposites

2015

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“…The factor A in Equation (12) relates to the band broadening resulting from eddy diffusion, whereby solutes are dispersed along the packing as the mobile phase percolates the stationary phase particles in a tortuous flow, where the different eluent flow streams experience pathways of varying flow resistance between the particles. The value of the constant A is roughly proportional to the particle diameter d p (Equation 13): The eddy diffusion term is also affected by the shape of the particles and the quality of packing.…”

Section: Macromolecules and Mass Transfer In Chromatographymentioning

confidence: 99%

“…Deviation from local equilibrium depends on the overall kinetics of the partitioning reaction within the column and is particularly important for biomacromolecules, because of their low diffusion rates. Factors that make up for the factor C in Equation (12) involve contributions from different impeding processes (Equation 15):…”

Section: Macromolecules and Mass Transfer In Chromatographymentioning

confidence: 99%

High‐Performance Liquid Chromatography of Biological Macromolecules

Irgum¹

2000

Encyclopedia of Analytical Chemistry

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“…Chitosan was immobilized on silica gel by adsorption in order to avoid of that [9,10]. Derivatives of chitosan and chitosan must display specific interactions with the silica gel surface: chemical bonding or specific adsorption.…”

Section: Introductionmentioning

confidence: 99%