Chitosan gel sheet containing drug carriers with controllable drug-release properties

Ito, Tomoki; Takami, Taku; Uchida, Yusuke; Murakami, Yoshihiko

doi:10.1016/j.colsurfb.2017.12.054

Cited by 24 publications

(8 citation statements)

References 68 publications

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“…To achieve the successful incorporation and release of drugs, we have developed a novel approach for the construction of functional biomaterials. We have applied this approach to the chemical or physical conjugation of functional units (such as amphiphilic block copolymers or their self-assemblies) to base materials, including gels [21,22,23,24,25,26,27,28], sheets [29,30,31], and particles [32,33,34,35,36]. For example, the covalent incorporation of trilayered polymeric micelles [37,38] with hydrophilic inner cores into gels gave them the ability to release hydrophilic compounds [24].…”

Section: Introductionmentioning

confidence: 99%

PLA- and PLA/PLGA-Emulsion Composite Biomaterial Sheets for the Controllable Sustained Release of Hydrophilic Compounds

2018

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In the present study, by spin-coating a solution containing w/o (water-in-oil) emulsions and hydrophobic polymers, we obtained sheets possessing uniformly dispersed w/o emulsions. We performed release experiments for more than 100 days and clarified the effects of the number of layers, the sheet-forming polymers (polylactide (PLA), poly(lactic-co-glycolic acid (PLGA)), the ratio of organic solvent to water, and the composition of block copolymers on the release properties of the sheets. For a variety of sheets, we successfully achieved the sustained release of compounds from the sheets for 100–150 days. The sustained-release of compounds occurred because the compounds had to diffuse into polymer networks after their release from the emulsions. Interestingly, we observed an inflection point in the release profiles at around 50 days; that is, the sheet exhibited a “two-step” release behavior. The results obtained in the present study provide strong evidence for the future possibility of the time-programmed release of multiple compounds from sheets.

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Section: Introductionmentioning

confidence: 99%

PLA- and PLA/PLGA-Emulsion Composite Biomaterial Sheets for the Controllable Sustained Release of Hydrophilic Compounds

2018

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“…To avoid drug resistance, the provision of a controlled release hydrogel carrier is necessary. Thanks to the high processability and the structural properties of MPs hydrogels, MPs-based antibiotic hydrogels could achieve a stable and slow release [316,317].…”

Section: Development Of Activities-enhanced Mps Wound Dressingsmentioning

confidence: 99%

Marine Polysaccharides for Wound Dressings Application: An Overview

et al. 2021

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Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

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“…Hydrogel is an important biological material which was widely used in tissue engineering and pharmaceutical applications [22][23][24][25]. Generally, hydrogel is composed of natural products and synthetic products, and its properties can be further modulated by physical interpenetration or chemical cross-linking [26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

“…Generally, hydrogel is composed of natural products and synthetic products, and its properties can be further modulated by physical interpenetration or chemical cross-linking [26][27][28][29]. Natural polysaccharides such as chitosan and its derivatives have good biocompatibility and biodegradability, and are widely used in drug delivery and tissue engineering [25]. Carboxymethyl chitosan (CMCS) is a kind of shell derivatives with the characteristics of chitosan.…”

Section: Introductionmentioning

confidence: 99%

PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration

Gong

Yao

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

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Chitosan gel sheet containing drug carriers with controllable drug-release properties

Cited by 24 publications

References 68 publications

PLA- and PLA/PLGA-Emulsion Composite Biomaterial Sheets for the Controllable Sustained Release of Hydrophilic Compounds

PLA- and PLA/PLGA-Emulsion Composite Biomaterial Sheets for the Controllable Sustained Release of Hydrophilic Compounds

Marine Polysaccharides for Wound Dressings Application: An Overview

PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration

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