Chitosan-Glycerol Phosphate/Blood Implants Improve Hyaline Cartilage Repair in Ovine Microfracture Defects

Hoemann, Caroline D.; Hurtig, Mark; Rossomacha, Evgeny; Sun, Jun; Chevrier, Anik; Shive, Matthew S.; Buschmann, Michael D.

doi:10.2106/jbjs.d.02536

Cited by 265 publications

(235 citation statements)

References 50 publications

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“…At six months, in the case of the defects that had been treated with chitosan-glycerol phosphate/blood it was observed significantly more hyaline repair tissue (p<0.05) and a much larger amount of cells and collagen compared with control [29]. In another study, chitosan was used in combination with glycerol phosphate (GP) and tested for cartilage repair in adult rabbits.…”

Section: Biomaterials In Cartilage Tissue Engineeringmentioning

confidence: 99%

Biomaterials for Cartilage Tissue Engineering

Grigore¹

2017

J Tissue Sci Eng

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One of the most challenging issues of musculoskeletal medicine is represented by injuries of the articular cartilage due to the poor regenerative properties of this tissue. A consequence of these injuries is represented by osteoarthritis. Osteoarthritis is the most common chronic condition of the joints, caused because of the progressive wear and tear on articular cartilage. A solution to prevent progressive joint degeneration in osteoarthritis is represented by a surgical intervention which offers the advantage of the success of total joint replacement, but also offers several disadvantages such as such as slower remodeling, immune reaction and disease transmission. In the last years, the researchers have found a solution to avoid surgical intervention by using biomaterials. This study aims to provide an updated survey of the major progress in the flied of biomaterials for cartilage tissue engineering, including biomaterials (natural, synthetic or composites), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the field of biomaterials for cartilage tissue repair and/or regeneration over the last years.

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Section: Biomaterials In Cartilage Tissue Engineeringmentioning

confidence: 99%

Biomaterials for Cartilage Tissue Engineering

Grigore¹

2017

J Tissue Sci Eng

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“…Las propiedades microestructurales, físicas y químicas de estas matrices acelulares (sin células), contribuyen a crear un microambiente adecuado para que células mesenquimales provenientes de la médula ósea se adhieran, proliferen, diferencien y recambien la matriz artificial por cartílago hialino (Hoemann et al, 2005;Kang et al, 2008;Erggelet et al, 2009;Kon et al, 2015). Tienen la ventaja de que se pueden aplicar en procedimientos mínimamente invasivos y en un solo paso quirúrgico; además, al no requerir cultivo celular son menos costosas, se puede disponer de ellas de forma inmediata y tienen menos restricciones regulatorias, Pot et al, 2016.…”

Section: Tratamientos De Las Lesiones Del Cartílago De La Rodillaunclassified

Terapias Celulares y Productos de Ingeniería de Tejidos para el Tratamiento de Lesiones Condrales de Rodilla

Cabrera

Duque²,

Fontanilla

2017

Rev. colomb. biotecnol.

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RESUMENEl cartílago articular es un tejido vulnerable a las lesiones de diferente etiología; siendo uno de los más afectados, el cartílago de la rodilla. Aunque la mayoría de los tratamientos convencionales reducen los síntomas, generalmente conducen a la formación de fibrocartílago; el cual, posee características diferentes a las del cartílago hialino de las articulaciones. Son pocas las aproximaciones terapéuticas que promueven el reemplazo del tejido dañado por cartílago hialino funcional; las más exitosas son las denominadas terapias avanzadas, que aplican células y productos de ingeniería de tejidos con el fin de estimular la regeneración del cartílago. La mayoría de ellas se basan en colocar soportes hechos con biomateriales de diferente origen, que sembrados o no con células exógenas o endógenas, reemplazan al cartílago dañado y promueven su regeneración. Este trabajo revisa algunas de las aproximaciones terapéuticas enfocadas en la regeneración del cartílago articular de rodilla; así como, los biomateriales más empleados en la elaboración de soportes para terapia celular e ingeniería de tejido cartilaginoso.Palabras clave: biomaterial, cartílago, lesiones de rodilla, ingeniería de tejidos. ABSTRACTThe articular cartilage is prone to suffer lesions of different etiology, being the articular cartilage lesions of the knee the most common. Although most conventional treatments reduce symptoms they lead to the production of fibrocartilage, which has different characteristics than the hyaline cartilage of the joint. There are few therapeutic approaches that promote the replacement of damaged tissue by functional hyaline cartilage. Among them are the so-called advanced therapies, which use cells and tissue engineering products to promote cartilage regeneration. Most of them are based on scaffolds made of different biomaterials, which seeded or not with endogenous or exogenous cells, can be used as cartilage artificial replacement to improve joint function. This paper reviews some therapeutic approaches focused on the regeneration of articular cartilage of the knee and the biomaterials used to develop scaffolds for cell therapy and tissue engineering of cartilage. ARTÍCULO DE REVISIÓNRev.

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“…La possibilità di creare un innesto "cell-free" sufficientemente "intelligente" da stimolare la rigenerazione ordinata e durevole del tessuto neoformato è ancora argomento di ricerca in numerosi studi su animali [15][16][17][18][19][20][21], e soltanto pochi di essi sono stati introdotti nella pratica clinica [22,23]. [1998][1999] and results at short-medium term follow up is well documented for different types of scaffold.…”

Section: Biomateriali "On Shelf"unclassified

“…Hoemann e coll. [17] hanno aggiunto chitosano-glicerolo fosfato/sangue autologo a un difetto cartilagineo trattato con microfratture in quattordici pecore. A sei mesi i difetti così trattati si sono riempiti di tessuto di riparazione sensibilmente più ialino (p<0,05) rispetto ai difetti di controllo.…”

Section: Biomateriali "On Shelf"unclassified