Chitosan-hydroxyapatite-MWCNTs nanocomposite patch for bone tissue engineering applications

Carbon-based electrically conductive materials for bone repair and regeneration

“…SWCNT gel scaffolds with nanofibrous architecture via the pairing of heparin functionalized nucleobases 95 Targeted drug delivery, increased mechanical properties, and improved osteogenic properties through the application of electrical stimulation 95 MWCNT compacts 96 Induction of osteogenic gene expression, increased protein adsorption and mineralization, and the influence of ectopic bone formation 96 MWCNT-COOH reinforced borosilicate BG scaffolds 97 Enhanced mechanical properties, bioactive behavior promoting hydroxyapatite formation, good cell viability, and osteogenic initiation 97 Chitosan-hydroxyapatite MWCNT nanocomposite films 98 Biocompatible, electrically conductive, and good mechanical properties 98 Polycaprolactone (PCL)/MWCNT scaffolds 99 Promotion of thick bone tissue formation in vivo, increased angiogenesis and mineralization of bone through electrical stimulation in vivo, and activation of osteoclastogenesis through electrical stimulation for bone remodeling 99 MWCNT reinforced polyvinyl alcohol/Biphasic calcium phosphate (PVA/BCP) scaffolds 100 Increased mechanical properties, high interconnectivity, and good biocompatibility 100 Bionic mineralized MWCNT scaffolds 101 Improved mechanical properties, enhanced cell growth in vitro and in vivo, increased osteogenic differentiation and promotion of bone defect repair in vivo 101…”

“…Human cortical and cancellous bone have electrical conductivities of 0.02 S m À1 and 0.07 S m À1 , respectively. 128 CNTs and graphene are two of the most attractive materials that are being used in scaffolds for bone repair and regeneration applications [97][98][99]103,105,107,111 as they possess very high electrical conductivities of 10 6 -10 7 S m À1 for pure CNTs and 10 8 S m À1 for pure graphene. 129 Therefore, hybrid bone scaffolds containing a low amount of CNTs or graphene can result in a conductivity that recapitulates endogenous bone.…”

Synthesis and Characterization of Hydroxyapatite/Alginate Composites: Study of pH and Sintering Influenced on the Structural, Morphological, and Clindamycin Release Behavior

“…To get more advantages of HAp, many scientists combine HAp with other materials, such as polymer [11][12][13][14], to obtain composite material. Sanchez et al [15] have successfully synthesized nanocomposite films of chitosan-HAp-MWCNT. These films contain 5.0% weight of HAp nanoparticles and 0.5% weight of MWCNT.…”

Enhancing surface morphology, mechanical, and wettability properties of PVA/chitosan/HAp nanofiber scaffold through dielectric barrier discharge plasma treatment

“…Chitosan (C 6 H 11 NO 4 )n is a natural polymer that presents intriguing biological properties such as non-antigenic, biocompatible, antibacterial, and good biodegradability [22,23]. Furthermore, Chitosan exhibits osteoconductive properties that can stimulate bone formation under in vivo and in vitro conditions, making it suitable for various tissue engineering applications [24,25].…”