Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system

Al-Remawi, Mayyas; Elsayed, Amani; Maghrabi, Ibrahim A.; Hamaidi, Mohammad; Jaber, Nisrein

doi:10.1080/10837450.2016.1213745

Cited by 53 publications

(28 citation statements)

References 39 publications

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“…These days, there has been a lot of interest in the investigation and feasibility of non-invasive routes for insulin delivery and their product developments in the pharmaceutical industry. These non-invasive routes (Khafagy et al 2007 ) include oral (Al-Remawi et al 2017 ), nasal (Bloch et al 2017 ), buccal (Kumria and Goomber 2011 ), pulmonary (Pfützner and forst 2005 ), transdermal (Leeladurga et al 2016 ), ocular (Lee et al 2002 ) and rectal (du Plessis et al 2010 ) drug delivery systems (Owens 2002 ; Cefalu 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Formulation, physicochemical characterization and in vitro evaluation of human insulin-loaded microspheres as potential oral carrier

Agrawal

Wakte

Shelke³

2017

Prog Biomater

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The objective of the present investigation was to formulate and characterize the human insulin entrapped Eudragit S100 microspheres containing protease inhibitors and to develop an optimized formulation with desirable features. A w/o/w multiple emulsion solvent evaporation technique was employed to produce microspheres of human insulin using Eudragit S-100 as coating material and polyvinyl alcohol as a stabilizer. The resultant microspheres were evaluated for drug-excipient compatibility, encapsulation efficiency, particle size, surface morphology, micromeritic properties, enteric nature, and in vitro drug release studies. Micromeritic properties indicated good flow properties and compressibility. In present investigation formulation F6 with drug/polymer ratio (1:100) was found to be optimal in terms of evaluated parameters where it showed a significantly higher percentage of encapsulation efficiency (76.84%) with minimal drug release (3.25%) in an acidic environment. The optimized formulation (F6) also possessed good spherical shape and particle size (57.42 µm) required to achieve the desired in vitro drug release profile at pH 7.4. The results confirmed that human insulin-loaded Eudragit S-100 microspheres containing protease inhibitor possessed good encapsulation efficiency, pH dependant controlled release carrying encapsulated insulin to its optimum site of absorption. This ultimately resulted in enhanced insulin absorption and biological response.Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Formulation, physicochemical characterization and in vitro evaluation of human insulin-loaded microspheres as potential oral carrier

Agrawal

Wakte

Shelke³

2017

Prog Biomater

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“…The first method of synthesis of liposomes is Extrusion, which in this process liposomes, depending on the pore-size of the filters employed, are structurally modified to large unilamellar vesicles (LUV) or nanoliposomes (Al-Remawi et al 2016. A high pressure cause extrusion of vesicles through polycarbonate filters (Figure 3).…”

Section: Extrusion Techniquementioning

confidence: 99%

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Panahi

Farshbaf

Mohammadhosseini

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

201

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Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability; accompanied by their nanosize they have potential applications in nanomedicine, cosmetics, and food industry. Nanoliposome technology offers thrilling chances for food technologists in fields including encapsulation and controlled release of food ingredients, also improved bioavailability and stability of sensitive materials. Amid numerous brilliant new drug and gene delivery systems, liposomes provide an advanced technology to carry active molecules to the specific site of action, and now days, various formulations are in clinical use. In this paper, we provide review of the main physicochemical properties of liposomes, current methods of the manufacturing and introduce some of their usage in food nanotechnology as carrier vehicles of nutrients, enzymes, and food antimicrobials and their applications as drug carriers and gene delivery agents in biomedicine.

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“…Liposomes were discovered in 1965 by Bangham and have become the most successful drug delivery system [1,2]. Since it is known that liposomes can increase the absorption of substances from the gastrointestinal tract (GIT)-shown by Sessa et al in 1970 [3]-the idea for using liposomes for oral drug delivery purposes exists, and has been followed for decades by many research groups [4][5][6][7][8]. The encapsulation of drugs in liposomes has many advantages: In addition to the high encapsulation efficiency of lipophilic and hydrophilic drugs, as well as their high biocompatibility, liposomes protect their cargo from external influences such as enzymatic degradation or premature metabolism [9].…”

Section: Introductionmentioning

confidence: 99%

Bolalipid-Doped Liposomes: Can Bolalipids Increase the Integrity of Liposomes Exposed to Gastrointestinal Fluids?

Müller

Gruhle

Meister³

et al. 2019

Pharmaceutics

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The use of archaeal lipids and their artificial analogues, also known as bolalipids, represents a promising approach for the stabilization of classical lipid vesicles for oral application. In a previous study, we investigated the mixing behavior of three single-chain alkyl-branched bolalipids PC-C32(1,32Cn)-PC (n = 3, 6, 9) with either saturated or unsaturated phosphatidyl-cholines. We proved, that the bolalipids PC-C32(1,32C6)-PC and PC-C32(1,32C9)-PC show miscibility with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). In the present work, we extended our vesicle system to natural lipid mixtures using phosphatidylcholine from soy beans, and we investigated the effect of incorporated bolalipids on the integrity of these mixed liposomes (bolasomes) in different gastrointestinal fluids using a dithionite assay and a calcein release assay in combination with particle size measurements. Finally, we also studied the retention of calcein within the bolasomes during freeze-drying. As a main result, we could show that in particular PC-C32(1,32C6)-PC is able to increase the stability of bolasomes in simulated gastric fluid—a prerequisite for the further use of liposomes as oral drug delivery vehicles.

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Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system

Cited by 53 publications

References 39 publications

Formulation, physicochemical characterization and in vitro evaluation of human insulin-loaded microspheres as potential oral carrier

Formulation, physicochemical characterization and in vitro evaluation of human insulin-loaded microspheres as potential oral carrier

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Bolalipid-Doped Liposomes: Can Bolalipids Increase the Integrity of Liposomes Exposed to Gastrointestinal Fluids?

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