Chitosan–N-poly(ethylene glycol) brush copolymers: Synthesis and adsorption on silica surface

Gorochovceva, Natalija; Naderi, Ali; Dédinaité, Andra; Makuška, Ričardas

doi:10.1016/j.eurpolymj.2005.05.021

Cited by 42 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Sun et al introduced a new kind of thin-film coating, synthesized from dimethylmethacrylate (DMA) copolymerized poly(glycidyl methacrylate) (GMA). This film demonstrates excellent long-term hydrophilicity and resistance to protein adsorption while enabling arbitrary patterning of cells on planar surfaces with precisely controlled distances of cell populations 105 .…”

Section: Pdms Surface Modification Strategiesmentioning

confidence: 99%

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

et al. 2017

View full text Add to dashboard Cite

In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications.

show abstract

Section: Pdms Surface Modification Strategiesmentioning

confidence: 99%

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Poly(ethylene glycol) (PEG) is an ideal graftforming polymer because it is soluble in both water and organic solvents and its low toxicity, good biocompatibility and biodegradability (Harris 1992); and approved use in food, cosmetics, personal care products and pharmaceutical (Tirelli et al 2002). Indeed, PEGylation of chitosan has been shown to improve the affinity to water or organic solvents, most commonly by reductive amination of chitosan with PEG-aldehyde in aqueous organic acid (Sugimoto et al 1998;Gorochovceva et al 2005;Bhattarai et al 2005b). Grafting PEG onto very short chitosan (M n = 28 kDa) produced water-soluble PEGylated chitosan (Sugimoto et al 1998), at a very low DS of 0.05.…”

Section: Introductionmentioning

confidence: 99%

PEGylation of chitosan for improved solubility and fiber formation via electrospinning

Hsieh

2007

Cellulose

View full text Add to dashboard Cite

PEG-N-chitosan and PEG-N,O-chitosan were synthesized via reductive amination and acylation of chitosan, respectively. The structures were confirmed by FTIR and H 1 NMR. The extents of PEGylation increased with reducing chain lengths of either chitosan (M v = 137-400 kDa) or poly(ethyelene glycol) (PEG, M n = 500-2 kDa). Water solubility were easily achieved at degree of substitution (DS) as low as 0.2 for either derivtive whereas the PEG-N,O-chitosan at DS = 1.5 was soluble in organic solvents, including CHCl 3 , DMF, DMSO and THF. None of the aqueous solutions of PEG-Nchitosan or PEG-N,O-chitosan alone could be electrospun into fibers. Electrospinning of PEG550-N,Ochitosan145 at 25% in DMF produced fibrous structure intermixed with beads. The efficiency of fiber formation and the uniformity of fibers were improved by increasing the solution viscosity using a cosolvent or reducing the solution surface tensions with a nonionic surfactant. Ultra-fine fibers with diameters ranging from 40 nm to 360 nm and an average diameter of 162 nm were efficiently generated from electrospinning of 15% PEG550-N,O-chitosan145 in 75/25 (v/v) THF/DMF cosolvents with 0.5% Triton X-100 TM .

show abstract

“…The polymer has been synthesized and characterized as described previously [22]. The structure of Chi-N -PEO is depicted in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…In array applications, the microcontact printing technique offers an appealingly straightforward route to achieve patterns in the µm size range [18,19]. In this work we utilized a recently described class of comb polyelectrolytes consisting of a chitosan backbone and a high density of grafted PEO side chains [20,21] to coat gold surfaces functionalized with 16-mercaptohexadecanoic acid. The comb polymer surface layers were prepared by adsorption, covalent attachment and microcontact printing, and their protein repellent properties were evaluated employing surface plasmon resonance (SPR) and imaging null ellipsometry (INE).…”

Section: Introductionmentioning

confidence: 99%

Chitosan-N-poly(ethylene oxide) brush polymers for reduced nonspecific protein adsorption

Zhou

Liedberg

Gorochovceva

et al. 2007

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

Chitosan–N-poly(ethylene glycol) brush copolymers: Synthesis and adsorption on silica surface

Cited by 42 publications

References 20 publications

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

PEGylation of chitosan for improved solubility and fiber formation via electrospinning

Chitosan-N-poly(ethylene oxide) brush polymers for reduced nonspecific protein adsorption

Contact Info

Product

Resources

About