Chitosan/Poly(2-ethyl-2-oxazoline) Films with Ciprofloxacin for Application in Vaginal Drug Delivery

Abstract

Chitosan (CHI) and chitosan/poly(2-ethyl-2-oxazoline) (CHI/POZ)-based films were prepared by casting from aqueous solutions of polymer blends with different compositions. Ciprofloxacin was used as a model drug in these formulations. The weight, thickness, folding endurance and transparency of blend films were measured and characterised. All films had a uniform thickness (0.06 ± 0.01 mm) and exhibited sufficient flexibility. The surface pHs of films ranged from 3.76 ± 0.49 to 4.14 ± 0.32, which is within the pH range suitable for vaginal applications. The cumulative release of the drug from the films in experiments in vitro was found to be 42 ± 2% and 56 ± 1% for pure CHI and CHI/POZ (40:60) films, respectively. Drug-free chitosan/poly(2-ethyl-2-oxazoline) films showed weak antimicrobial activity against Escherichia coli. Drug-loaded CHI and CHI/POZ films showed good antimicrobial properties against both Gram-positive Staphylococcus aureus and Gram-negative bacteria Escherichia coli. Mucoadhesive properties of these films with respect to freshly excised sheep vaginal mucosa were evaluated using a tensile method. It was established that all films were mucoadhesive, but an increase in POZ content in the blend resulted in a gradual reduction of their ability to stick to vaginal mucosa. These films could potentially find applications in vaginal drug delivery.

Chitosan‐based nanocomposites for medical applications

“…47 The surface characteristics of freestanding films can be fine-tuned by different post-treatment techniques. Owing to its outstanding mechanical and biological properties, chitosan nanocomposite films have already been used in various biomedical applications including wound dressing patches, [48][49][50][51] drug delivery, 52,53 implant coatings, [54][55][56] and as scaffolds. 57,58 Various nanoparticles such as nanoclay, 59 graphene, 60 silver, 61 cellulose whisker, 62 and titania 63 have been used for the preparation of chitosan nanocomposites films for such applications.…”

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

“…In addition, POZ is a non-ionic polymer, which possesses a weak mucoadhesion property. This study shows that combination of cationic and non-ionic polymer in the formulation would greatly reduce the mucoadhesive property as the non-ionic polymer occupied and decreased the concentration of the more mucoadhesive component (chitosan) [ 93 ]. Tentor et al also performed a study on the chitosan-based membrane for vaginal application.…”

“…Both formulations from Abilova et al and Tentor et al were effective against E. coli , S. aureus , and G. vaginalis , which are the common pathogens found in BV. These studies suggested that the AC membrane and chitosan-based film are potential formulations for the management of BV [ 93 , 94 ]. Besides that, Jalil et al had developed an antimicrobial vaginal film using the thiolated gellan gum and loaded with metronidazole to treat vaginal infection.…”

Exploring new avenues in physical chemistry of hydrophilic polymers: to the 70th anniversary of Professor Sarkyt Elekenovich Kudaibergenov

“…Часть результатов его докторской диссертации были опубликованы в виде обзора в журнале «Успехи химии» [8], в котором отражено впервые обнаруженное им явление «изоэлектрического эффекта» выталкивания в области изоэлектрической точки полиамфолитов (рисунок 3). [17], получение полимерных пленок на границе несмешивающихся жидкостей [18], теоретические исследования образования солевых связей в цепях полиамфолитов [19], разработку полимерных композиций как структурирующих агентов для предотвращения миграции радионуклидов и для их извлечения из почв [20,21], получение полимер-протектированных и гель-иммобилизованных наночастиц металлов и исследования их каталитических свойств [22,23] в качестве проточных каталитических реакторов (рисунок 7), синтез и исследования макропористых криогелей [24], синтез гидрофобно-модифицированных полимеров и гидрогелей [25], исследования по применению водорастворимых полисахаридов в нефтедобыче [26], а также создание полимерных систем доставки лекарств [27,28].…”