Chlamydia trachomatis infection in children with wheezing simulating asthma

Bavastrelli, M.; Midulla, M; Rossi, Daniela; Salzano, Marco

doi:10.1016/0140-6736(92)90776-y

Cited by 8 publications

(4 citation statements)

References 2 publications

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“…This suggests that these later infections may have been contracted through increased social interactions, possibly in pre-school or day care settings. These findings agree with previously published data, suggesting that Ct can be found in the lower respiratory tract of newborns and can lead to pneumonitis [12,15,21]. Evidence for the presence of Ct in the human placental tissue also exists [40][41][42].…”

Section: Discussionsupporting

confidence: 92%

“…Published reports have documented that many infants infected with Ct at birth remain infected for months or years in the absence of specific antimicrobial therapy [20]. Indeed, some reports have suggested that wheezing may be another clinical expression of Ct infection and that this organism should be routinely assayed for in children who wheeze but have no demonstrable allergy and do not respond to the usual anti-asthmatic medications [21]. The current authors recently confirmed the presence of Chlamydia in bronchoalveolar lavage fluid (BALF) samples from paediatric patients with various chronic respiratory diseases using PCR and tissue culture techniques [22].…”

mentioning

confidence: 99%

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Occurrence ofChlamydia trachomatisandChlamydia pneumoniaein paediatric respiratory infections

Webley¹,

Tilahun²,

Lay³

et al. 2008

Eur Respir J

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An emerging body of evidence suggests that half of asthma in both children and adults is associated with chronic lung infection. The aim of the present study was to determine the frequency of viable Chlamydia pneumoniae (Cp) and C. trachomatis (Ct) in the respiratory tracts of paediatric patients with chronic respiratory diseases.Bronchoalveolar lavage fluid (BALF) samples obtained from 182 children undergoing bronchoscopy for clinical reasons were assayed using PCR analysis, in vitro tissue culture and immunofluorescence staining for the presence of Cp and Ct.Chlamydia-specific DNA was detected by PCR in 124 (68%) out of 182 patients; 79 were positive for Cp, 77 positive for Ct and 32 for both organisms; 75 patients had cultivable Chlamydia. Ct DNA prevalence decreased, whereas Cp positivity generally increased with age. A total of 59 out of 128 asthma patients and 16 out of 54 nonasthmatics were Chlamydia culture positive. When the patients were divided into inflammatory versus noninflammatory airway disease, there were 69 (46%) out of 150 and six (18%) out of 32 BALF samples with cultivable Chlamydia, respectively.Viable Chlamydia pneumoniae and Chlamydia trachomatis occur frequently in children with chronic respiratory diseases and may be more prevalent in asthma patients. To the current authors' knowledge, this is the first report of viable Chlamydia trachomatis in the lungs of children.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Occurrence ofChlamydia trachomatisandChlamydia pneumoniaein paediatric respiratory infections

Webley¹,

Tilahun²,

Lay³

et al. 2008

Eur Respir J

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“…The role of C trachomatis as a respiratory pathogen after the neonatal period is controversial. C trachomatis was isolated from pharyngeal swabs in seven of 20 children with wheezing37 and serological evidence of acute infection with C trachomatis was found in 19.2% of Argentinian children aged 1–18 months with acute lower respiratory tract infection 38. On the other hand, C trachomatis could not be isolated from 48 children newly admitted to an asthma clinic in the UK,39 and Hahn and coworkers6 did not find any correlation between C trachomatis antibody titres and wheezing in children and adults with lower respiratory tract infection.…”

Section: Acute Bronchitis and Bronchiolitismentioning

confidence: 99%

Lung infections bullet 4: Pathogenesis of lower respiratory tract infections due to Chlamydia, Mycoplasma, Legionella and viruses

Andersen¹

1998

Thorax

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“…26 Importantly, children may also have an asymptomatic infection that may not present as pneumonia, but may alter immune programming and lung structure to promote the development of an ''asthmalike'' phenotype in later life. 27 Furthermore, pediatric patients with underlying chronic respiratory conditions, especially asthma, are more likely to be positive for C. trachomatis infection, with 77/182 (42.3%) of the pediatric patients studied positive for C. trachomatis DNA. 28 C. pneumoniae is an important respiratory pathogen that is a common cause of community-acquired pneumonia in children.…”

Section: Introductionmentioning

confidence: 99%

Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease

Starkey

Nguyen²,

Kim³

et al. 2013

Clinical Obstetrics &Amp; Gynecology

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There is emerging evidence that chronic respiratory diseases such as asthma and emphysema may originate in early life. Respiratory infections with certain bacterial pathogens such as Chlamydia, Haemophilus influenzae and Streptococcus pneumoniae in early life may promote permanent deleterious changes in immunity, lung structure, and function that predispose to, or increase the severity of chronic respiratory diseases in later life. For example, these infections increase immune responses, which drive subsequent asthma pathogenesis. Targeting the pathways involved with specific inhibitors or agonists may prevent these consequences of early-life infection. Vaccination and immunomodulatory therapies that control the infections and their sequelae may also be efficacious.

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Chlamydia trachomatis infection in children with wheezing simulating asthma

Cited by 8 publications

References 2 publications

Occurrence ofChlamydia trachomatisandChlamydia pneumoniaein paediatric respiratory infections

Occurrence ofChlamydia trachomatisandChlamydia pneumoniaein paediatric respiratory infections

Lung infections bullet 4: Pathogenesis of lower respiratory tract infections due to Chlamydia, Mycoplasma, Legionella and viruses

Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease

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