Chlamydia trachomatis Infection Is Related to Poor Semen Quality in Young Prostatitis Patients

Mazzoli, Sandra; Cai, Tommaso; Addonisio, Patrizia; Bechi, Adriano; Mondaini, Nicola; Bartoletti, Riccardo

doi:10.1016/j.eururo.2009.05.015

Cited by 92 publications

(68 citation statements)

References 27 publications

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“…Patients with MAGI, especially when associated with C. trachomatis or U. urealyticum infection, often present significantly reduced sperm concentration, total sperm number, motile spermatozoa, or sperm with normal morphology [13,24]. However, the degree of impaired semen quality seems to be directly related to the extension of MAGI [72].…”

Section: Role Of Oxidative Stressmentioning

confidence: 95%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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The invasion of the male reproductive tract by microorganisms, and its subsequent consequences for sperm fertilizing potential, has been intensely discussed. The role of the bacteria that are responsible for the colonization and contamination of the male urogenital tract, rather than its infection, in diminished sperm parameters raises the most controversy. There are numerous premises suggesting that bacterial semen infection is associated with male infertility. However, the molecular mechanism by which the fertility is affected is complex and multifactorial, and still presents a puzzle. Some authors have suggested that direct interactions between bacteria and human spermatozoa facilitate sperm immobilization, affect sperm morphology, and thus weaken the ability of sperm to fertilize. On the other hand, the massive infiltration of activated leukocytes into the inflammatory site may be associated with impairment of sperm fertilizing potential, due to oxidative, apoptotic, and immune processes. This review presents current research trends and aims to summarize the present knowledge of semen inflammation and causative bacterial agents in the male urogenital tract, with its consequence on seminological parameters, and male fertility status.

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Section: Role Of Oxidative Stressmentioning

confidence: 95%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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“…This correlation was shown by the presence of proinflammatory cytokines in exposed tissues (IL-6, IL-10 and IL-8) (70). Of note, Chlamydia trachomatis is capable of inducing modifications of sperm quality in male individuals affected by CP (71). In a recent study (unpublished data) in which 1161 CP patients (mean age, 36.5 years old) were enrolled, 707 patients were affected by CBP caused by common uropathogens, and 454 patients had CP associated with C. trachomatis prostate infection.…”

Section: Two Pivotal Macrolide Targets In the Prostate Gland: Intracementioning

confidence: 95%

Macrolides for the treatment of chronic bacterial prostatitis: An effective application of their unique pharmacokinetic and pharmacodynamic profile (Review)

et al. 2011

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Abstract. Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a permanent cure. Although fluoroquinolones are currently recommended as first-choice agents, macrolide antibiotics are emerging as a noteworthy option for the treatment of CBP. Macrolide antibiotics are characteri zed by an impressive array of distinct pharmacokinetic (PK) and pharmacodynamic (PD) properties. These properties include high intracellular accumulation in phagocytes and at sites of infection, including the prostate; broad antibiotic but also biofilm-inhibiting properties; immunomodulating and inflammation-resolving activities. These features offer particular advantages for the treatment of chronic infections of the prostate gland, which are not easily amenable to drug therapy. Macrolides may be exploited to counteract the unsatisfactory rates of clinical symptom improvement and pathogen eradication. The results of a number of clinical trials support this proposal.

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“…Finally, another example of the controversial role of C. trachomatis in semen parameters is observed in prostatitis patients. Whereas Mazzoli et al found that C. trachomatis affects sperm concentration, percentage of motile sperm and normal morphological forms in prostatitis patients [66], Motrich et al found that chlamydial infection has no detrimental effects on sperm quality [67]. Thus, for a number of reasons, mostly based on methodological aspects, the impact of C. trachomatis on semen parameters is controversial and further investigations should be performed to understand the disparities seen among the available studies.…”

Section: Direct Interaction Of C Trachomatis With Sperm Function Andmentioning

confidence: 99%

The Role of Chlamydia trachomatis in Male Infertility

et al. 2012

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Chlamydia trachomatis Infection Is Related to Poor Semen Quality in Young Prostatitis Patients

Cited by 92 publications

References 27 publications

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Macrolides for the treatment of chronic bacterial prostatitis: An effective application of their unique pharmacokinetic and pharmacodynamic profile (Review)

The Role of Chlamydia trachomatis in Male Infertility

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