Chlorin-PEI-labeled cellulose nanocrystals: Synthesis, characterization and potential application in PDT

Drogat, Nicolas; Granet, Robert; Morvan, Caroline Le; Bégaud-Grimaud, G.; Krausz, Pierre; Sol, Vincent

doi:10.1016/j.bmcl.2012.04.044

Cited by 64 publications

(36 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Poly(2-(DiMethylAmino) Ethyl Methacrylate (PDMAEMA) brushes-modified CNCs are reported as a pDNA delivery in vitro as well as in vivo (Hu et al 2015). Another study demonstrated the chlorin-PEI-labelled CNCs as potential photosensitizers with antitumour activity against the HaCat cell line (Drogat et al 2012). On the other hand, the highly charged (carboxylated) CNCs (~3.8 mmol g −1 )…”

Section: Introductionmentioning

confidence: 99%

Internalization of (bis)phosphonate-modified cellulose nanocrystals by human osteoblast cells

et al. 2017

View full text Add to dashboard Cite

Covalent conjugation of (bis)phosphonate group-containing molecules, sodium Alendronate (Aln) and 3-AminoropylPhosphoric Acid (ApA), to Cellulose nanocrystals (CNCs) was performed via oxidation/Shiff-base reaction. Further fluorescent labelling with Rhodamine B Iso ThioCyanate (RBITC) was performed to follow CNCs interaction and potential internalization with/in human osteoblasts by confocal microscopy. Complementary analyses were applied to identify the conjugation (Atenuated Total Reflectance-Fourier Transform Infrared and UV-VIS spectroscopies), physico-chemical (Dynamic Light Scattering and Nanoparticle Tracking Analysis) and morphological (Transmission Electron Microscopy) features of native and ApA/Aln-modified CNCs in physiologically relevant environments (Phosphate Buffer Saline, Advanced Dulbecco's Modified Eagle Medium). While conjugation did not affect the CNCs' size, the RBITC-labelling promotes their aggregation. Faster (1 h vs. 2 h) uptake by osteoblasts of RBITCCNCoxAln, compared to RBITC-CNCoxApA, and no-internalization (in 24 h) of native RBITTC-CNC, indicate a higher affinity of Aln-modified CNCs to the cells, while all CNCs (in 0.25-0.06 wt%) promote the cell growth. Aln/Apa-modified CNCs shows high potential in drug-delivery for bone therapies, and theranostics.

show abstract

Section: Introductionmentioning

confidence: 99%

Internalization of (bis)phosphonate-modified cellulose nanocrystals by human osteoblast cells

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Moreover, a previous study reported the good skin tolerance of BC membranes [15]. Chitosan, which is chemically related to cellulose and plant cellulose nanocrystals, has been studied by Schmitt et al [16] and Drogat et al [17] in the photodynamic therapy. In view of these facts, the development of new delivery systems that can efficiently deliver ClAlPc could enable its clinical use for topical PDT.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 98%

Infrared to Visible Up-conversion in Biocellulose–yttrium Vanadate Nanoparticle Composite Membranes. Demonstration of Chloroaluminum Phthalocyanine Light Emission Under Up-converted Light Excitation

Nigoghossian¹,

Peres²,

Primo³

et al. 2014

Colloids and Interface Science Communications

View full text Add to dashboard Cite

Biocellulose Chloroaluminum phthalocyanine Yttrium vanadate nanoparticles lanthanide ions photodynamic therapy photosensitizers drug delivery systems biomaterials composite membranes YVO 4 :(Yb 3+ -Er 3+ /Ho 3+ ) nanoparticles were incorporated in biocellulose membranes obtained from Gluconacetobacter xylinus. Materials present the property of converting near-infrared (NIR) into higher-energy visible light. Nanoparticles were prepared by optimizing towards higher emission intensity at the absorption wavelength range of chloroaluminum phthalocyanine (ClAlPc) used as a photosensitizer in the photodynamic therapy. The NIR excitation wavelength is advantageous for biological applications, as it allows deeper penetration into tissues than the UV-visible radiation commonly used for luminescence excitation. Up-conversion emission spectra obtained under excitation at 980 nm showed a preferential green emission for the Yb 3+ -Er 3+ system and a red emission for the Yb 3+ -Ho 3+ one. In the last case, by using mixtures of nanoparticles and ClAlPc the red emission (680 nm) of the phtalocyanine was observed through excitation by the up-converted emission of the nanoparticles (650 nm) which were excited in NIR (980 nm).

show abstract

“…[25][26][27][28][29][30] Dif-ferentC NC functionalizationp rocedures have been described, [31] commonly startingw ith ac ovalent modification of the CNC surfacet op rovide reactive functional groups or supramolecular recognitionm otifs. [32][33][34][35][36] Among them, only few examples have exploited CNC in combination with dyes, mainly porphyrinoids and rutheniumc omplexes,f or catalytic or biomedical applications. [24,[36][37][38][39][40][41][42] Our strategy to decorate CNC with Pc molecules relies on the octacationic zinc Pc (ZnPc)d erivatives 1 and 2,w hich can bind through electrostatic interactions to the negatively chargeds urfaceo fs ulfated CNC.…”

Section: Introductionmentioning

confidence: 99%

Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

Anaya‐Plaza

Winckel

Mikkilä

et al. 2017

Chemistry A European J

View full text Add to dashboard Cite

The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.

show abstract

Chlorin-PEI-labeled cellulose nanocrystals: Synthesis, characterization and potential application in PDT

Cited by 64 publications

References 28 publications

Internalization of (bis)phosphonate-modified cellulose nanocrystals by human osteoblast cells

Internalization of (bis)phosphonate-modified cellulose nanocrystals by human osteoblast cells

Infrared to Visible Up-conversion in Biocellulose–yttrium Vanadate Nanoparticle Composite Membranes. Demonstration of Chloroaluminum Phthalocyanine Light Emission Under Up-converted Light Excitation

Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

Contact Info

Product

Resources

About