Choice of Silver Drugs in Therapy of Rhinosinusitis  at Children Age

Белов, В. А.; Белова, О. Ю.

doi:10.21518/2079-701x-2016-16-60-63

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Сиалор ® обладает вяжущим, противовоспалительным, антисептическим действием. Механизм действия препарата основан на способности образующихся при диссоциации ионов серебра связываться с ДНК бактерий, препятствуя их размножению, осаждать белки и образовывать защитную пленку из альбуминов серебра на поверхности поврежденной слизистой оболочки полости носа и околоносовых пазух, что благоприятно влияет на ее восстановление [10,15,16].…”

Section: оториноларингология/Otorhinolaryngologyunclassified

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Овчинников¹,

Мирошниченко²,

Nikolaeva³

2020

Russian Medical Inquiry

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Inflammatory diseases of the nasal cavity and paranasal sinuses are identified as the leading cause of upper respiratory disorders. Nose breathing is of crucial importance to provide the entry for air to get into the respiratory system. In addition to oxygen saturation, nose breathing provides the exchange of air in the paranasal sinuses. This process is required to maintain normal microflora of the nasal cavity. In contrast, mouth breathing occurring during the inflammatory diseases of the nasal cavity is associated with discomfort and poor health-related quality of life and results in inflammation. Viral inflammatory disorders often exacerbate a patient’s condition and provoke bacterial inflammation. Recent widespread occurrence of antimicrobial resistance forced to change the paradigm in the treatment of inflammatory disorders and to refocus on time-proved topical therapies. Systemic antibiotics are now used only for strict indications. Other treatment options are widely applied. Thus, silver preparations characterized by antiseptic and bactericidal properties allow to avoid complications and to aid the recovery. They are the best choice of topical agents for treating acute rhinosinusitis. KEYWORDS: acute rhinitis, acute rhinosinusitis, acute respiratory viral infections, antibacterial drugs, topical treatment, argentum proteinate. FOR CITATION: Ovchinnikov A.Yu., Miroshnichenko N.A., Nikolaeva Yu.O. Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx. Russian Medical Inquiry. 2020;4(4):238–242. DOI: 10.32364/2587-6821-2020-4-4-238-242.

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Section: оториноларингология/Otorhinolaryngologyunclassified

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Овчинников¹,

Мирошниченко²,

Nikolaeva³

2020

Russian Medical Inquiry

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“…This film reduces the permeability of the mucous membrane to bacteria and provides the normal functional state of cells, promoting rapid tissue repair. Local anti-inflammatory and anti-edematous effects are associated with a decrease in the lumen and permeability of the capillaries of the mucous membrane [7,8].…”

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confidence: 99%

The study of the stability of silver proteinate solutions prepared in pharmacies

Cherniakova,

Bevz,

Strilets

et al. 2023

SR: PS

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Today, medicines made in pharmacies are increasingly attracting consumers' attention and are in growing demand in Ukraine. Pharmacy production faces a number of problems, including the study of the stability of extemporaneous dosage forms and the determination of an optimal shelf life. 1 % and 2 % water silver proteinate solutions used in ophthalmology, otolaryngology and nephrology are produced in Ukrainian pharmacies both extemporaneously and as a reserve. The aim. The aim of the work is to develop methods for quality support and study the chemical stability of 1 % and 2 % water solutions of silver proteinate, and to study the microbiological purity to extend the storage time of nasal drops. Materials and methods. A study of the chemical stability of 1 % and 2 % water silver proteinate solutions of pharmaceutical production is carried out using chemical identification reactions (to silver and protein), quantitative determination by thiocyanatometric titrimetric method and determination of microbiological purity. Results. The validation characteristics of the method for the quantitative thiocyanatometric determination of silver proteinate were studied (the correlation coefficient r = 0.9995 and 0.9996; the systematic error – 0.26 % and 0.03 %, the relative confidence interval – 0.88 % and 0.74 % for 1 % and 2 % solutions, respectively), as well as its suitability for this purpose was proven. “Silver proteinate solution, 1.0 %” and “Silver proteinate solution, 2.0 %” prepared in the pharmacy were studied for 150 days by the “Microbiological purity” indicator and were biologically stable. Conclusions. The chemical identification reactions and methods for the quantitative determination of silver proteinate in an extemporaneous dosage form used to study the chemical stability of the drug have been proposed. The study results of the chemical stability and microbiological purity allow us to recommend pharmacies to extend the shelf life of nasal drops containing silver proteinate as an active pharmaceutical ingredient for 150 days

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Complex treatment of diseases of the nasal cavity and paranasal sinuses at the present time

Свистушкин

Eremeeva

2021

Medicinskij sovet

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The search for rational treatment of diseases of the nasal cavity and paranasal sinuses is due to the high incidence among the world's population. Despite the absolutely clear recommendations that would seem to greatly facilitate the choice and scope of therapy, it is extremely important to have a differentiated approach to each patient, depending on age, concomitant pathology, the nature of the course of the disease, the severity of clinical, primarily pain symptoms, and the presence of rhinogenic complications. Differential diagnosis of viral and bacterial acute rhinosinusitis (ARS) allows to avoid unreasonable prescription of antibiotics in the former case and choose therapy in such a way as to help relieve clinical symptoms, timely cure the disease and prevent complications. A systematic review of the literature was conducted with the analysis of scientific research data on the evaluation of the effectiveness of protargol or silver proteinate in the local treatment of upper respiratory tract diseases. A review of studies shows that silver proteinate has astringent, antiseptic and anti-inflammatory effects. The spectrum of antimicrobial action of silver is much wider than many antibiotics and sulfonamides. At the same time, pathogenic microflora is more sensitive to silver ions than non-pathogenic microflora. The analysis of the works also demonstrates the absence of adverse reactions when using this drug. The obtained data allow us to recommend preparations based on silver proteinate as a complex therapy for acute and chronic diseases of the nasal cavity and nasopharynx. The vasoconstrictive effect of protargol allows it to be used as an alternative to decongestants in order to avoid the development of drug-induced rhinitis and tachyphylaxis. Sialor® is a new, convenient, affordable, longer-shelf-life form of silver proteinate.

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Choice of Silver Drugs in Therapy of Rhinosinusitis at Children Age

Cited by 4 publications

References 8 publications

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

The study of the stability of silver proteinate solutions prepared in pharmacies

Complex treatment of diseases of the nasal cavity and paranasal sinuses at the present time

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