Cholangiocarcinoma with a Background of Hepatitis B Virus-associated Cirrhosis.

Abstract

Recently, hepatitis virus-associated chronic hepatitis or cirrhosis has been suggested to be involved in the pathogenesis of cholangiocarcinoma (CC). A 52-year-old manwas diagnosed as CCwith a background of hepatitis B virus (HBV)-dependent cirrhosis. A minute hepatic tumor was found during the follow-up, and was diagnosed as CC on percutaneous biopsy. The patient died of hepatic failure and an autopsy revealed the tumor to be a well to moderately differentiated adenocarcinoma. An immunohistological analysis of HBVX gene-encoded protein (HBX) was neither detected in the cancerous nor in the noncancerous tissue. Nooncogenic role of the virus was verified in this case. (Internal Medicine 40: 382-385, 2001)

Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a case–control study in China

“…Our findings are consistent with the results reported by a few non‐Chinese studies that have evaluated the role of HBV infection and cirrhosis in the development of ICC (18, 19, 26–30). Taking these studies into account, there seems to be reasonable epidemiological evidence for a causal relationship between HBV and ICC.…”

Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infection

“…Interestingly, one of the persons with occult HBV had a partial hepatectomy for cholangiocarcinoma. While HBV is more tightly linked to the development of HCC, there are several reports of HBV DNA and protein detected in cholangiocarcinoma [20][21][22]. These studies consist of case series or case reports, so the true prevalence of occult HBV in this setting is unknown.…”

Detection of hepatitis B virus DNA in paraffin-embedded intrahepatic and extrahepatic cholangiocarcinoma tissue in the northern Chinese population

“…Therefore, identification of other risk factors is important. Infection with HBV or HCV has been suggested as a potential risk factor for CC [19,20]. A prospective cohort study from Japan showed that 2.3% of 600 patients with HCV-related cirrhosis developed ICC during a mean follow-up of 7.2 years.…”