Cholesterol and Triglycerides Concentrations of Lipopolysaccharide-Induced Inflammatory Male Rat in Response to Petiveria alliacea L. Leaf Extract

Ogunrin, Olabisi O.; Ogunrinola, Olabisi; Ogunrin, Oluwaseyi A.; Adegbul, Josephine A.; Adu, O. B.

doi:10.3923/jas.2022.100.106

Cited by 3 publications

(9 citation statements)

References 28 publications

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“…"Triglyceride, phospholipid, and cholesterol partake in numerous biochemical reactions and integrate metabolic pathways. Any alteration in the lipids will affect the other metabolites that are directly or indirectly connected with them" [5,3]. "They are structural components of the cellular membrane" [3,23].…”

Section: Discussionmentioning

confidence: 99%

“…The acute toxicity (LD 50 ) of C. glaucum bulb aqueous extract was determined by oral route using the modified method of Ogunrinola et al [5] and Adu et al [18].…”

Section: Acute Toxicity Studiesmentioning

confidence: 99%

“…The supernatant (lipid extract) was stored for further analysis. The commercially available kits were used to determine the cholesterol, triglycerides, and phospholipid concentrations in the plasma, lipid extracts from erythrocytes, brain, heart, lung, kidney, and liver, respectively [4][5][6]22].…”

Section: Biochemical Analysismentioning

confidence: 99%

“…Lipid molecules such as cholesterol, phospholipids, and triglycerides are transported through the blood as lipoproteins for vital metabolic functions [1][2][3][4][5][6]. Cellular membrane structural elements contain protein complexes like ion channels, receptors, and scaffolding complexes [3].…”

Section: Introductionmentioning

confidence: 99%

“…Cellular membrane structural elements contain protein complexes like ion channels, receptors, and scaffolding complexes [3]. For energy balance, reproductive and organ physiology, as well as many other aspects of cellular biology, lipids are crucial [3][4][5][6]. Homeostasis disturbances of these lipids result in dyslipidemia, which is connected to a variety of clinical conditions, including diabetes, heart disease, inflammation, and obesity [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Crinum glaucum Bulb Extract Improves the Lipid Profile of Endotoxin-Induced Wistar Rats

Ogunrinola

Kanmodi

Adeyemo

et al. 2022

AJRB

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Background and Objective: Medicinal plants are widely known as sources of potential that are used in traditional medicine. The effect of Crinum glaucum (C. glaucum) aqueous extract on the lipid profile of endotoxin-induced rats was evaluated. Methodology: Fifty Wistar rats (male and female) were divided randomly into five groups (n = 5). Group 1 is the control group. Group 2 was administered C. glaucum aqueous extract (1000 mg/kg body weight). Group 3 was endotoxin-induced with 1 ml/kg body weight single dose of lipopolysaccharide (LPS) for 4 hours. Group 4 was given LPS (4 hours) and treated with C. glaucum aqueous extract. Group 5 was administered C. glaucum aqueous extract, LPS, and C. glaucum aqueous extract. At the end of administration, blood and organs (brain, heart, lungs, liver, and kidney) were harvested for the lipid profile (triglyceride, cholesterol, and phospholipid) assay analysis using a spectrophotometric method. Results: The reduction of cholesterol, triglyceride, and phospholipid concentrations is the hallmark of endotoxin, as revealed in this study. While C. glaucum administration significantly (p<0.05) reduced cholesterol concentrations, there was an up- or down-regulation of triglyceride and phospholipid concentrations in the male compartments compared to the control. A similar trend was observed in the female compartment. Data also revealed that while LPS causes a reduction in lipid profiles, the administration of C. glaucum reverses the effect. Conclusion: The findings of the research suggest that C. glaucum has an ameliorative and therapeutic effect in improving lipid dysfunctions.

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Section: Discussionmentioning

confidence: 99%

“…The acute toxicity (LD 50 ) of C. glaucum bulb aqueous extract was determined by oral route using the modified method of Ogunrinola et al [5] and Adu et al [18].…”

Section: Acute Toxicity Studiesmentioning

confidence: 99%

Section: Biochemical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Crinum glaucum Bulb Extract Improves the Lipid Profile of Endotoxin-Induced Wistar Rats

Ogunrinola

Kanmodi

Adeyemo

et al. 2022

AJRB

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Therapeutic Role of Crinum glaucum Bulb against Haematological and Hepatic Enzyme Alterations in a Rat Model

Olatunji,

Ogunrinola,

Ogunrinola

et al. 2023

AJBGMB

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Aims: Several parts of medicinal plants have been known to have many health benefits. One of those plants is the Crinum glaucum (CG) bulb. Therefore, this research was undertaken to investigate the therapeutic role of an aqueous extract of CG bulb (aeCGb) against lipopolysaccharide (LPS)-induced haematological and hepatic enzyme alterations in male and female rat models. Study Design and Methodology: Twenty-five male and twenty-five female rats were divided randomly into five groups (n = 5) each. Group 1 is the control group. Group 2 was administered with 1000 mg/kg body weight of aeCGb. Group 3 was exposed to 4 ml/kg body weight of LPS for 4 hours. Group 4 was administered LPS (4 hours) and 1000 mg/kg body weight of aeCGb. Group 5 was administered 1000 mg/kg body weight of aeCGb and LPS for 4 hours. The albumin, total protein, bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase (hepatic enzyme) concentrations and haematological parameters were analysed spectrophotometrically. Results: The hallmark of LPS is its ability to decrease the concentration of hepatic enzymes and the levels of haematological parameters, as observed. The levels of albumin, total protein, and direct and total bilirubin were significantly (P≤ .05) increased in the aeCGb-treated groups. However, treatment with aeCGb reverses the damaging effect of LPS on hepatic enzyme concentration. Conclusion: The results suggest that aeCGb has a therapeutic role in the LPS-induced alterations by correcting the concentration of hepatic enzyme function as well as regulating the levels of haematological parameters.

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Curculigo pilosa rhizome Supplementation Reverses P-Hydroxyacetanilide-Induced Oxidative Stress and Lipid Profile Dysfunction in Rats

Olabisi,

Oluwaseyi,

Iweunor

et al. 2023

AJRB

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Exposure to drug toxicity results in stress and dysfunction of metabolizing enzymes that cause illnesses and diseases. Consumption of medicinal plant rhizomes is a regime for managing the complications. On the activities of some oxidative stress marker enzymes (catalase, glutathione, and superoxide dismutase), as well as the concentration of lipid profiles (cholesterol, triglycerides, and phospholipids) of p-hydroxyacetanilide (pPHA)-induced toxicity in rats, the effects of an aqueous extract of Curculigo pilosa (C. pilosa) rhizome were assessed. Forty rats were randomly grouped into eight groups (n = 5). The control group; aqueous extract of C. pilosa rhizome group; 750 mg/kg and 1000 mg/kg per body weight of pPHA group; the preventive groups (aqueous extract of C. pilosa rhizome and 750 mg/kg per body weight of pPHA; aqueous extract of C. pilosa rhizomes and 1000 mg/kg per body weight of pPHA); and the curative groups (750 mg/kg per body weight of pPHA and aqueous extract of C. pilosa rhizome; 1000 mg/kg body weight of pPHA and aqueous extract of C. pilosa rhizome). The oxidative stress marker enzymes and lipid profiles were analyzed spectrophotometrically in the serum, kidney, brain, and liver of the animals on the seventh and fourteenth days after the administrations. The results show that pPHA decreases the oxidative stress marker activities and the lipid profile concentrations in all the compartments, but the pre- and post-treatment with an aqueous extract of C. pilosa rhizome improved the activities of the stress marker enzymes and the lipid profiles dysfunction. The result suggests that an aqueous extract of C. pilosa rhizome has preventive and curative therapeutic potential for pPHA-induced toxicity.

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Cholesterol and Triglycerides Concentrations of Lipopolysaccharide-Induced Inflammatory Male Rat in Response to Petiveria alliacea L. Leaf Extract

Cited by 3 publications

References 28 publications

Crinum glaucum Bulb Extract Improves the Lipid Profile of Endotoxin-Induced Wistar Rats

Crinum glaucum Bulb Extract Improves the Lipid Profile of Endotoxin-Induced Wistar Rats

Therapeutic Role of Crinum glaucum Bulb against Haematological and Hepatic Enzyme Alterations in a Rat Model

Curculigo pilosa rhizome Supplementation Reverses P-Hydroxyacetanilide-Induced Oxidative Stress and Lipid Profile Dysfunction in Rats

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