Cholesterol content of serum lipoprotein fractions in children maintained on chronic hemodialysis

Gambert, Philippe; Lallemant, Christian; André, J. L.; Athias, Anne; Bourquard, Rosine; Pierson, M; Padieu, P

doi:10.1016/0009-8981(81)90358-2

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Since the HDL-cholesterol concentration is simultaneously decreased in these patients [4,6,11], there is an impaired HDL-LCAT sys tem in haemodialysed patients which could lead to cholesterol accumulation in cells as observed in human LCAT deficiency states. Therefore, it is of particular interest that our present study demonstrates a normal LCAT activity in renal transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

LecithiniCholesterol Acyltransferase Activity and HDL Composition in Serum of Patients with Kidney Transplants

Jung¹,

Neumann²,

Scholz³

et al. 1983

Enzyme

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In comparison with a control group, lecithinxholesterol acyltransferase activities and HDL-cholesterol concentrations in serum of patients with kidney transplants were unchanged, while apolipoprotein A and HDL-triglyceride concentrations were increased. This constellation shows that the cholesterol metabolism in patients with kidney transplants differs from that of patients undergoing chronic haemodialysis.

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Section: Discussionmentioning

confidence: 99%

LecithiniCholesterol Acyltransferase Activity and HDL Composition in Serum of Patients with Kidney Transplants

Jung¹,

Neumann²,

Scholz³

et al. 1983

Enzyme

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Lipoprotein Profiles in Plasma and Dialysate of Children on CAPD

Querfeld¹,

Haberbosch²,

Gnasso³

et al. 1985

CAPD in Children

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Lipoprotein metabolism in chronic renal insufficiency

Saland

Ginsberg

2007

Pediatr Nephrol

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Chronic renal insufficiency (CRI) is associated with a characteristic dyslipidemia. Findings in children with CRI largely parallel those in adults. Moderate hypertriglyceridemia, increased triglyceride-rich lipoproteins (TRL) and reduced high-density lipoproteins (HDL) are the most usual findings, whereas total and low-density lipoprotein cholesterol (LDL-C) remain normal or modestly increased. Qualitative abnormalities in lipoproteins are common, including small dense LDL, oxidized LDL, and cholesterol-enriched TRL. Measures of lipoprotein lipase and hepatic lipase activity are reduced, and concentrations of apolipoprotein C-III are markedly elevated. Still an active area of research, major pathophysiological mechanisms leading to the dyslipidemia of CRI include insulin resistance and nonnephrotic proteinuria. Sources of variability in the severity of this dyslipidemia include the degree of renal impairment and the modality of dialysis. The benefits of maintaining normal body weight and physical activity extend to those with CRI. In addition to multiple hypolipidemic pharmaceuticals, fish oils are also effective as a triglyceride-lowering agent, and the phosphorous binding agent sevelamer also lowers LDL-C. Emerging classes of hypolipidemic agents and drugs affecting sensitivity to insulin may impact future treatment. Unfortunately, cardiovascular benefit has not been convincingly demonstrated by any trial designed to study adults or children with renal disease. Therefore, it is not possible at this time to endorse general recommendations for the use of any agent to treat dyslipidemia in children with chronic kidney disease.

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Cholesterol content of serum lipoprotein fractions in children maintained on chronic hemodialysis

Cited by 4 publications

References 18 publications

LecithiniCholesterol Acyltransferase Activity and HDL Composition in Serum of Patients with Kidney Transplants

LecithiniCholesterol Acyltransferase Activity and HDL Composition in Serum of Patients with Kidney Transplants

Lipoprotein Profiles in Plasma and Dialysate of Children on CAPD

Lipoprotein metabolism in chronic renal insufficiency

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