Cholinergic M4 receptors are involved in morphine-induced expression of behavioral sensitization by regulating dopamine function in the nucleus accumbens of rats

Ruan, Heng; Sun, Jun-hong; Liu, Xinhe; Liu, Liyuan; Cui, Ruisi; Li, Xinwang

doi:10.1016/j.bbr.2018.12.009

Cited by 7 publications

(7 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 Many brain diseases are associated with changes in the morphology and density of dendritic thorns. 13 Morphine can reduce the length and number of dendritic thorns in nucleus accumbens by affecting the neurotropic factors in the striatum. 26 A study by Robinson et al revealed that morphine injections reduced the length and the number of dendritic thorns, which is consistent with the results of our study.…”

Section: Discussionmentioning

confidence: 99%

“…32 Jalili et al found that aqueous extract of Boswellia serrata administration as an antioxidant caused increased number of dendritic processes and thorns in kindled rats, confirming the results of the present study. 13 It also amplified the effects of antioxidant enzymes such as catalase and superoxide dismutase, and reduced ROS production. 33 In the current study, a significant growth was observed in serum nitrite oxide and serum total antioxidant levels in the morphine group compared to the sham group.…”

Section: Discussionmentioning

confidence: 99%

“…Microscopic sections (5 µm) were prepared and examined morphologically. 13 Dendritic Thorns Dendritic thorn count was made via microscopic examination with an optical microscope and Motic software and ImageTool IT (version 3) software. In the slides stained through Golgi staining technique, we included neurons entirely stained with cell bodies in the central part of the tissue slices away from the surrounding stained neurons.…”

Section: Golgi Methodsmentioning

confidence: 99%

“…8 It is addictive and causes physiological dependence, which spreads throughout the brain tissues in 10-20 seconds. 9,10 It then rapidly passes through the blood-brain barrier, and can regulate brain neurotransmitters, including catecholamine and serotonin A. 11 Meanwhile, dopaminergic structure shows a significant role in controlling the memory.…”

Section: Introductionmentioning

confidence: 99%

“…Stimulation of these receptors increases dopamine release in the prefrontal cortex and induces feelings of euphoria in the user. 13 However, morphine can induce oxidative stress in organs such as the brain., 14 increase oxidative stress and neuronal apoptosis, destroy DNA, and produce reactive oxygen species. [14][15][16] Among the brain areas heavily affected by morphine is mesocorticolimbic and brain's prefrontal regions.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effects of Royal Jelly on the Prefrontal Cortex in a Rat - Morphine Toxicity Model

Jalili

Roshankhah

Mohammadi

et al. 2019

J Apple Biotechnol Rep

View full text Add to dashboard Cite

Introduction: Royal jelly (RJ) is a honey bee secretion with numerous medicinal properties and antioxidant activities. Morphine is a major risk factor in the development of functional disorders in several organ systems. This study was designed to evaluate the effects of RJ against morphineinduced damage to the prefrontal cortex of rats. Materials and Methods: In this study, 48 male Wistar rats were randomly assigned into 6 groups: sham group, morphine group, RJ groups (100, and 200 mg/kg), and morphine + RJ groups. Treatments were administered intraperitoneally and orally for 20 days on a daily basis. Ferric reducing/ antioxidant power (FRAP) method was applied to determine the total antioxidant capacity. The number of neurons and, dendritic spines were investigated by Golgi technique, and Griess technique was employed to determine the serum nitrite oxide level. Results: Morphine administration significantly increased the nitrite oxide level and total antioxidant capacity, and reduced neuronal dendritic spines and neurons compared to the sham group (P < 0.05). In all RJ and Morphine + RJ groups, the number of neurons and neuronal dendritic spines were elevated significantly, while nitrite oxide level and total antioxidant capacity were reduced compared to the morphine group (P < 0.05). Conclusions: RJ administration protected animals against oxidative stress and nitrite oxide. It also improves some prefrontal cortex parameters including number of neurons and dendritic spines because of the morphine.

show abstract

Section: Discussionmentioning

confidence: 99%