Cholinesterase Enzymes Inhibitory Activities of Methanolic and Aqueous Extracts of Different Parts of

Muniandy, Jayadhisan; Sadikun, Amirin; Murugaiyah, Vikneswaran

doi:10.2174/2210289201304010031

Cited by 8 publications

(1 citation statement)

References 45 publications

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“…This compound will inhibit the hypoxia-inducible factor 1 (HIF-1) signaling pathway which is the pathway for angiogenesis stimulation (64). Reserpine also demonstrated the anti-fibrotic and anti-inflammatory activity of the compounds present in MOSEIL, this compound will prevent the formation of fibroblast cells by inhibiting the differentiation of mesenchymal stromal cells (MSCs) (65). After the active compounds MOSEIL and MOLP are molecularly docked with the same target protein, namely TGF-β1, both can be known to cause cancer cells.…”

Section: Molecular Docking Analysis and Visualization Of Molp And Moseilmentioning

confidence: 98%

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

Susanto,

Wonorahardjo,

Putra

et al. 2023

Mal. J. Fund. Appl. Sci.

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Hepatocellular carcinoma (HCC) is one of the deadliest types of cancer with a mortality rate of 8.9% of the total cancer deaths in Indonesia. This cancer can be caused by exposure to hepatitis B and C viruses, NAFLD, autoimmune, diabetes to sporadic genetic diseases. The development of chronic HCC is generally preceded by the occurrence of severe liver fibrosis and cirrhosis. One of the genes that play a role in fibrosis in the incidence of HCC is TGF-β1. As a pro-fibrotic cytokine, the presence of high levels of TGF-β1 may be due to oxidative stress activity early in cancer development. One of the natural ingredients with lots of phytochemical content in the form of antioxidants that can reduce this activity is Moringa plant (Moringa oleifera). In this study we used a computational approach using molecular docking on the results of the GC-MS and LC-HRMS tests on Moringa oleifera Seed Oil (MOSEIL) and Moringa oleifera Leaves Powder (MOLP) which are oil and flour products made from moringa. The results of the identification of phytochemical compounds through the GC-MS test showed that the dominant compound in MOSEIL was oleic acid (37.546%) and in MOLP was ester (8.802%) when using n-hexane as solvent. The percentage yield of the dominant compound from the LC-HRMS test in MOSEIL was nitro compound (72.55%) and at MOLP was alcohol (45.87%). These compounds are known to have effects as hepatoprotective agents through antioxidant, anti-inflammatory, and anti-fibrotic activities that can reduce hepatic oxidative stress as an early trigger of cancer development. Through molecular docking, MOSEIL and MOLP showed a lower level of binding affinity when compared to TGF-β1 control drugs such as metformin. This data implies MOSEIL and MOLP have a strong interaction to TGF-β1 than the control drug. The therapeutic potential of the hepatoprotective properties of MOSEIL and MOLP makes them one of the most-promising therapeutic agents in the initial step of renewable cancer treatment therapy.

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Section: Molecular Docking Analysis and Visualization Of Molp And Moseilmentioning

confidence: 98%

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

Susanto,

Wonorahardjo,

Putra

et al. 2023

Mal. J. Fund. Appl. Sci.

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EPR and Mössbauer Characteristics of Aqueous Solutions of 57Fe-Dinitrosyl Iron Complexes with Glutathione and Hydroxyl Ligands

et al. 2019

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Response of Hemopoietic, Progenitor, and Multipotent Mesenchymal Stromal Cells to Administration of Ketanserin during Pulmonary Fibrosis

et al. 2014

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We studied the effect of ketanserin on hemopoietic progenitor cells (Lin(-)Sca-1(+)c-Kit(+)CD34- and Lin(-)Sca-1(+)c-Kit(+)CD34(+)), progenitor hemopoietic cells (Lin(-)Sca-1(+)c-kit(+)), and multipotent mesenchymal stromal cells (CD45(-)CD73(+)CD106(+)) in C57Bl/6 mice during pulmonary fibrosis. It was shown that the blocker of 5-HT2A receptors lowers the activity of bleomycin-induced inflammation in the lungs and prevents the infiltration of alveolar interstitium and alveolar ducts by hemopoietic stem and hemopoietic progenitor cells; in this case, they are more numerous in the bone marrow of sick animals. Ketanserin reduces the capacity for self-renewal of lung multipotent mesenchymal stromal cells in the fibrotic phase of the disease and inhibits their differentiation into stromal cell lines (adipocytes, chondrocytes, and fibroblasts) simultaneously with the decrease in the percentage of connective tissue in the lung parenchyma.

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Cholinesterase Enzymes Inhibitory Activities of Methanolic and Aqueous Extracts of Different Parts of

Cited by 8 publications

References 45 publications

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

EPR and Mössbauer Characteristics of Aqueous Solutions of 57Fe-Dinitrosyl Iron Complexes with Glutathione and Hydroxyl Ligands

Response of Hemopoietic, Progenitor, and Multipotent Mesenchymal Stromal Cells to Administration of Ketanserin during Pulmonary Fibrosis

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