Chondromyxoid fibroma of bone: Thirty-six cases with clinicopathologic correlation

Zillmer, Debra A.; Dorfman, Howard D.

doi:10.1016/0046-8177(89)90267-0

Cited by 152 publications

(160 citation statements)

References 14 publications

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“…A typical appearance of CMF is a nearly hemispherical "bite" from the cortical margin without periosteal reaction. 4,24,25 This characteristic finding has been found in three of our patients (Figure 2). …”

Section: Discussionsupporting

confidence: 48%

Imaging features of chondromyxoid fibroma: report of 15 cases and literature review

Cappelle¹,

Pans²,

Sciot³

2016

BJR

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Section: Discussionsupporting

confidence: 48%

Imaging features of chondromyxoid fibroma: report of 15 cases and literature review

Cappelle¹,

Pans²,

Sciot³

2016

BJR

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“…Commonly confusing histological differential diagnoses include chondroblastoma and chondrosarcoma [13,15,27]. In our series of CMF, chondroblastoma was initially diagnosed in one case.…”

Section: Discussionmentioning

confidence: 91%

“…CMF presents in the second to third decade, has a male to female ratio of 2 to 1 and is found most often in the metaphysis around the knee in the proximal tibia, proximal fibula or distal femur [1,4,10,25]. A cartilaginous origin, originally proposed on morphological grounds, was subsequently supported by ultrastructural studies and the demonstration of S-100 protein by immunohistochemical studies [27].…”

Section: Discussionmentioning

confidence: 92%

Chondromyxoid fibroma of the foot and ankle: 40 years’ Scottish bone tumour registry experience

Sharma

Jane

Reid

2006

International Orthopaedics (SICO

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Ten cases of histologically proven chondromyxoid fibroma (CMF) of the foot and ankle with a mean follow-up of 6.1 years were retrospectively reviewed using the Scottish Bone Tumour Registry. The patients' mean age was 19 years; there were six males and four females. The anatomical locations were five phalangeal, three metatarsal, one tarsal affecting body of os calcis and one distal tibial. The median delay in presentation was 4.5 months. The modes of presentation were pain only (n=4), painful lump (n=4) and painless lump (n=2). The typical radiological finding was an expansile, lobulated, cystic lesion. Cortical erosion was documented in 80% patients. In four cases, curettage alone was carried out, while five patients underwent curettage along with autogenous bone grafting. One patient with distal phalangeal CMF had a primary toe amputation. Two patients had recurrences 9 and 16 months after their initial curettage. Both of them were males with proximal phalangeal CMF, associated with cortical erosion. Foot and phalangeal CMF initially treated with curettage only should be closely followed up, as we observed a 20% recurrence rate within a 2-year period. Cases featuring cortical erosion require thorough curettage and may require autogenous bone grafting to prevent fracture.Résumé Nous avons revu rétrospectivement à l'aide du registre Ecossais des tumeurs osseuses, dix cas de fibromes chondromyxoides du pied et de la cheville. L'âge moyen était de 19 ans avec une répartition par sexe suivante : 6 garçons et 4 filles. La localisation anatomique de la tumeur était cinq fois une phalange, trois fois un métatarsien, une fois un os du tarse et une fois l'extrémité inférieure du tibia. Le délai moyen de consultation était de quatre mois et demi, les patients consultant quatre fois pour une douleur, quatre fois pour une boiterie douloureuse, deux fois pour une boiterie non douloureuse. Les lésions kystiques étaient radiologiquement typiques de type lobulées. L'atteinte corticale a été retrouvée dans 80% des cas. Pour quatre cas nous avons procédé à un curetage isolé, dans cinq cas à un curetage associé à une auto-greffe. Un cas (atteinte de la phalange distale) a bénéficié d'une amputation d'orteil. Deux cas ont récidivé à neuf et seize mois après le curetage, il s'agissait d'un sujet masculin avec une atteinte de la phalange distale et une érosion corticale. Les fibromes chondromyxoides du pied et de la phalange qui ont initialement été traités par curetage isolé ont récidivé dans les deux ans, dans 20% des cas. Lorsque les lésions entraînent une érosion corticale, il est nécessaire d'associer au curetage une greffe, afin de prévenir le risque de fracture.

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“…Central portions of the tumor have greater cellularity and heterogeneous population of multinuclear giant cells 1,5 . The metaphysys of the long bones is the most common primary site; vertebral involvement is uncommon and occurs in only 8% of cases Only 10 cases involving the cervical spine have been reported, none in C1 (Table 1) [1][2][3][4][5][6][7][8][9] . A female preponderance was observed in patients with cervical spinal CMF, with C2 being most commonly affected.…”

Section: Discussionmentioning

confidence: 99%

“…The spine is an uncommon primary site with only 10 cases of CMF in the cervical spine reported to date [1][2][3][4][5][6][7][8][9] . However, there are no reports of CMF involving the first-cervical (C1) vertebra.…”

Section: Introductionmentioning

confidence: 99%

Chondromyxoid fibroma of C1: first case report

et al. 2012

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Background: Chondromyxoid fibroma (CMF) is a rare, benign primary bone tumor. The cervical spine is an uncommon site for this tumor, with only 10 reported cases to date and none involving the first cervical vertebra (C1). Case Report: Female patient, 25-year-old monozygotic female twin, presented with cervical pain. Radiographic imaging demonstrated a contrast-enhanced, right-sided lytic lesion of the insufflated type in C1, with a punched-out appearance and extending to the anterior arch. A postero-lateral and a posterior approach were performed in two steps to resect the tumor followed by occipitocervical fixation. Pathology confirmed the diagnosis of CMF. At one year, the patient remains disease free with excellent spinal stability. Conclusion: Spinal surgeons may need to treat rare spinal tumors. Despite the proximity to neural and vascular structures, the goal of surgery is always a radical resection due to high recurrence rates.

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Chondromyxoid fibroma of bone: Thirty-six cases with clinicopathologic correlation

Cited by 152 publications

References 14 publications

Imaging features of chondromyxoid fibroma: report of 15 cases and literature review

Imaging features of chondromyxoid fibroma: report of 15 cases and literature review

Chondromyxoid fibroma of the foot and ankle: 40 years’ Scottish bone tumour registry experience

Chondromyxoid fibroma of C1: first case report

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