Choosing the Right Benzodiazepine Assay: Impact on Clinical Decision Making

French, Deborah; Stone, Judith F.; Chang, Judy S.; Wu, Alan H.B.

doi:10.1309/lmdnlg1zvos2r8tv

Cited by 7 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The amount of active enzyme formed and the resulting extinction variation are proportional to the amount of drug present in the sample. In order to improve the sensitivity of the test, an optional enzyme is added to hydrolyze the glycoconjugate metabolites of BZDs, thus favoring the detection of samples containing BZDs metabolites [38, 53, 54, 60–64].…”

Section: Methods Commonly Used For the Analysis Of Bzds In Biologimentioning

confidence: 99%

See 1 more Smart Citation

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Qriouet

Qmichou

Bouchoutrouch

et al. 2019

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. Unfortunately, these drugs are present in the illegal street market, leading to a lot of drug abuse amongst some addicted users, road insecurity, and suicide. Hence, it has become essential to analyze the BZDs drugs in human biological specimens for drug abuse in forensic sciences. The present review provides a summary of sample preparation techniques (solid-phase extraction and Liquid-liquid phase extraction) and the methods for the detection and quantification of BZDs molecules in the commonly used biological specimens over the ten last years which may potentially lead to better and accurate evaluation of the physiological state of a given person. The commonly used methods for the detection and quantification of BZDs include nuclear magnetic resonance (NMR), chromatography (GC-MS, HPLC, and TLC), immunoassay (ELISA, RIA, LFA, CEDEA, FPIA, and KIMS), and electroanalytical methods (voltammetry and potentiometry).

show abstract

Section: Methods Commonly Used For the Analysis Of Bzds In Biologimentioning

confidence: 99%

“…Hence, the identification is based on the specific detection of high mass ions of the substance to be analyzed. The search for the identity of the specific ions obtained is performed by comparison with a given reference library [10, 13, 15, 18, 60].…”

Section: Methods Commonly Used For the Analysis Of Bzds In Biologimentioning

confidence: 99%

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Qriouet

Qmichou

Bouchoutrouch

et al. 2019

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

show abstract

“…e amount of active enzyme formed and the resulting extinction variation are proportional to the amount of drug present in the sample. In order to improve the sensitivity of the test, an optional enzyme is added to hydrolyze the glycoconjugate metabolites of BZDs, thus favoring the detection of samples containing BZDs metabolites [38,53,54,[60][61][62][63][64].…”

Section: Cloned-enzyme Donor Immunoassay (Cedia)mentioning

confidence: 99%

“…Hence, the identification is based on the specific detection of high mass ions of the substance to be analyzed. e search for the identity of the specific ions obtained is performed by comparison with a given reference library [10,13,15,18,60].…”

Section: Gas Chromatography Coupled To Mass Spectrometry (Gc-ms)mentioning

confidence: 99%

See 1 more Smart Citation

Analytical Methods used for the detection and quantification of benzodiazepines

Qriouet¹

2019

Preprint

View full text Add to dashboard Cite

The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. Unfortunately, these drugs are present in the illegal street market, leading to a lot of drug abuse amongst some addicted users, road insecurity, and suicide. Hence, it has become essential to analyze the BZDs drugs in human biological specimens for drug abuse in forensic sciences. The present review provides a summary of sample preparation techniques (solidphase extraction and Liquid-liquid phase extraction) and the methods for the detection and quantification of BZDs molecules inthe commonly used biological specimens over the ten last years which may potentially lead to better and accurate evaluation of the physiological state of a given person. The commonly used methods for the detection and quantification of BZDs include nuclear magnetic resonance (NMR), chromatography (GC-MS, HPLC, and TLC), immunoassay (ELISA, RIA, LFA, CEDEA, FPIA, and KIMS), and electroanalytical methods (voltammetry and potentiometry).

show abstract

Drug testing in the era of new psychoactive substances

Gerona

French

2022

Advances in Clinical Chemistry

View full text Add to dashboard Cite

Choosing the Right Benzodiazepine Assay: Impact on Clinical Decision Making

Cited by 7 publications

References 19 publications

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Analytical Methods Used for the Detection and Quantification of Benzodiazepines

Analytical Methods used for the detection and quantification of benzodiazepines

Drug testing in the era of new psychoactive substances

Contact Info

Product

Resources

About