Choroidal Metastasis of Breast Cancer: A Case Report and Literature Review

Berrad, S.

doi:10.34297/ajbsr.2020.11.001617

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…However, recent developments in the therapy of BC and management of metastatic diseases, led to an increase in the 5year breast-cancer-specific survival from 74.0% during 1975 to 1979 [19] to 90% in 2016, according to Surveillance, Epidemiology and End Results (SEER) data [9,19,20]. The estimated incidence of choroidal metastases in patients with disseminated BC varies from 2 to 13% in different studies [8,52]. In a study by Wiegel et al [52], asymptomatic BC choroidal metastasis (CM) was observed in 11% of patients with more than one affected organ and the risk factors associated with choroidal metastases were pulmonary and cerebral dissemination.…”

Section: Introductionmentioning

confidence: 99%

Intravitreal Anti-Vegf Therapy for Ocular Metastasis in Breast Cancer

Şerban¹

2022

FARMACIA

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Ocular metastases are the most common form of malignancy encountered in ophthalmology, in most cases associated with breast cancer as the primary tumour. Standard local therapy in case of ocular metastases that do not respond to systemic chemotherapy consists of external irradiation or brachytherapy, with multiple disadvantages related to the required logistics and multiple sessions as well as serious post-radiotherapy complications. The present systematic review discusses the efficiency and safety of intravitreal therapy with anti-vascular endothelial growth factor (anti-VEGF) agents used against choroidal metastases secondary to breast cancer. After an extensive search on PubMed, Google scholar and Web of science databases, 15 articles presenting data on 18 patients were included. The injected doses varied between 1.25 and 4 mg/session, with a monthly repetition of 3.9 ± 1.9 sessions. After treatment, it was reported that tumour size decreased in size in 94.5% of cases, the subretinal fluid decreased or resolved in 73.3% of cases, and vision improved in 61.1% of cases. The intravitreal injection of anti-VEGF agents as a simple and easy therapeutic approach that is free from the local ocular post-radiotherapy complications, can be considered a local adjuvant therapy to systemic chemotherapy. RezumatMetastazele oculare sunt cea mai frecventă formă de malignitate întâlnită în oftalmologie, în cele mai multe cazuri asociate cu cancerul de sân ca tumoare primară. Terapia locală standard în cazul metastazelor oculare care nu răspund la chimioterapia sistemică constă în iradierea externă sau brahiterapia, cu multiple dezavantaje legate de logistica necesară și de multiplele ședințe și complicațiile grave ale radioterapiei. Prezentul review abordează eficiența și siguranța terapiei intravitreale cu agenți anti-VEGF (anti-factor de creștere endotelială) utilizați împotriva metastazelor coroidiene secundare cancerului de sân. În urma unei căutări extinse în bazele de date PubMed, Google Scholar și Web of Science, au fost identificate 15 articole care prezintă date despre 18 pacienți. Dozele injectate au variat între 1,25 și 4 mg/sesiune, cu o repetare lunară de 3,9 ± 1,9 ședințe. După tratament, s-a raportat că dimensiunea tumorii a scăzut în 94,5% din cazuri, lichidul subretinian a scăzut sau sa remis în 73,3% dintre cazuri, iar vederea s-a îmbunătățit în 61,1% dintre cazuri. Injectarea intravitreană a agenților anti-VEGF poate fi considerată o terapie locală adjuvantă la chimioterapia sistemică.

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Section: Introductionmentioning

confidence: 99%

Intravitreal Anti-Vegf Therapy for Ocular Metastasis in Breast Cancer

Şerban¹

2022

FARMACIA

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“…Studies have shown that patients with breast cancer are exposed to a lot of stress that can cause psychological and social disorders in their lives.The most important risk factors for breast cancer are age, sex, family history of cancer, and hormonal factors. Fortunately, cancer treatment has progressed amazingly, surgery, chemotherapy, and radiotherapy can destroy tumors and arrest cancer progression [28,29]. In recent years, the use of nanotechnology to diagnose and treat cancer has made significant progress [30][31][32].…”

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confidence: 99%

Insight into Neurodevelopmental Disorders Related to the Imbalance of Monoamine Neuroactive Metabolites and Essential Amino Acids

Yamashita¹

2018

BJSTR

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Cancer is one of the leading causes of death in the world and is the third leading cause of death in most countries after traffic accidents and cardiovascular mortality [1][2][3][4]. Cancer has become a major public health problem in the world and every day, many people in different parts of the world are going to die cause of cancer [5,6]. Also, cancer and its treatment can weaken the immune system and reduce the ability to fight infections, thus increasing the risk of death from infectious disease [7]. In recent years, with increased greenhouse gases and weather change, and environmental pollution, human health is increasingly at risk and the incidence of cancer has risen in some countries [8][9][10][11][12][13][14][15][16][17][18][19][20]. Breast, colorectal, and stomach cancers are the most common cancers for women, and stomach, prostate, and colorectal cancers are the most common cancers in men [21,22]. Breast cancer is known as the most common malignancy among women and causes many deaths every year [23]. Despite many advances in the early diagnosis and proper treatment of this disease, it is still the leading cause of death among women [24-26]. The disease originates from breast tissue cells. When normal cells in the breast begin to change and grow uncontrollably and they form tumors, at which point cancer begins [27]. The tumor is identified after the biopsy as non-cancerous or malignant. Breast cancer affects women between the ages of 15 and 85. Studies have shown that patients with breast cancer are exposed to a lot of stress that can cause psychological and social disorders in their lives.The most important risk factors for breast cancer are age, sex, family history of cancer, and hormonal factors. Fortunately, cancer treatment has progressed amazingly, surgery, chemotherapy, and radiotherapy can destroy tumors and arrest cancer progression [28,29]. In recent years, the use of nanotechnology to diagnose and treat cancer has made significant progress [30][31][32]. Nanoparticles have the ability to penetrate cancer cells and can increase the concentration of drugs in them [33,34]. Carbon nanomaterials such as nanotubes, expanded graphite, graphene, and graphene oxide are ARTICLE INFO ABSTRACTEvery day we see progress in medicine and the treatment of many diseases. Cancer has been associated with human life for more than two decade and every day, many people in different parts of the world are going to die cause of cancer. Breast cancer is the most common among women. However, with the advancement of medical science, many cases can be treated. There are several sciences involved in this treatment, one of which is polymer engineering. Polymers have many applications in the treatment field for reasons such as biodistribution and biocompatible. Also, polymers are unique candidates for the release of anticancer drugs. This study briefly introduces breast cancer and several polymer-carriers.

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Choroidal Metastasis of Breast Cancer: A Case Report and Literature Review

Cited by 2 publications

References 10 publications

Intravitreal Anti-Vegf Therapy for Ocular Metastasis in Breast Cancer

Intravitreal Anti-Vegf Therapy for Ocular Metastasis in Breast Cancer

Insight into Neurodevelopmental Disorders Related to the Imbalance of Monoamine Neuroactive Metabolites and Essential Amino Acids

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