Chromatographic fingerprint analysis—a rational approach for quality assessment of traditional Chinese herbal medicine

Xie, Peng; Chen, Sibao; Liang, Yi‐Zeng; Wang, Xianghong; Tian, Ruijun; Upton, Roy

doi:10.1016/j.chroma.2005.12.091

Cited by 411 publications

(221 citation statements)

References 2 publications

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“…These studies thus have limited application as quality-control tools for G. biloba supplements. Other studies have discussed the potential of using chromatographic fingerprints as a quality-control tool for herbal medicines [30,31], but did not address specific productrelated problems in detail.…”

Section: Pca Analysis Of Chromatographic Fingerprintsmentioning

confidence: 99%

Chromatographic fingerprint analysis for evaluation of Ginkgo biloba products

2007

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The flavonoids and the terpene lactones are regarded as the two main active components of Ginkgo biloba that affect human health. In the work discussed in this paper, two analytical methods for the characterization of G. biloba authentic materials and commercial products, an LC-UV chromatographic fingerprinting method and a traditional flavonol quantification method, were compared. The traditional method was used to determine the total flavonol content (as glycosides) after acid hydrolysis. The fingerprinting method examined the chromatographic profiles of methanol-water extracts using chemometric methods. The traditional method showed that all the commercial products met the current voluntary standard of 24% flavonols by weight. The chromatographic fingerprinting method revealed significant variations in the commercial products with regard to the relative concentration of individual flavonols.

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Section: Pca Analysis Of Chromatographic Fingerprintsmentioning

confidence: 99%

Chromatographic fingerprint analysis for evaluation of Ginkgo biloba products

2007

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“…When cos α ij is 1, they are identical. If they were higher than 0.900, it indicated the qualities of samples were relatively consistent [7].…”

Section: Data Analysis Of Chromatogram Similarity Analysismentioning

confidence: 99%

Chromatographic Fingerprint Analysis and Characterization of Constituents in Shenqi Fuzheng Injection by HPLC-DAD-ELSD and UFLC-DAD-Q-TOF Tandem Mass Spectrometry Techniques

Wang

Liu

Tong

et al. 2015

Acta Chromatographica

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Summary. Shenqi Fuzheng Injection (SFI) is a traditional Chinese medicine injection, widely used to enhance immune function of clinical cancer patients undergoing chemotherapy. In this study, a high-performance liquid chromatography-diode array detection-evaporative light scattering detection (HPLC-DAD-ELSD) method was established for quality control of SFI, which could simultaneously semiquantitatively reflect the constituents displayed in the chromatographic profile of SFI. The relative retention time and relative peak areas of the 21 common peaks related to the reference peak were calculated. The validity and advantage of this method were validated by systematically comparing chromatograms of 10 batches of SFI samples with the analytical methods of principal component analysis and angle cosine method recommended by the State Food and Drug Administration of China. Moreover, a total of 21 constituents of SFI were identified or tentatively characterized in the fingerprint via ultrafast liquid chromatography-diode array detection-quadrupole time-of-flight (UFLC-DAD-Q-TOF) tandem mass spectrometry technique on the basis of the retention time, ultraviolet spectra, fragmentation patterns, and reported literatures. All the results proved that the technique was useful in comprehensive quality evaluation of SFI and further study.

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“…Yang et al [19] The HPLC FPS of commercial samples of Ginkgo biloba extracts (EGb) obtained from different sources were studied by Xie et al [18]. The HPLC FPS of components of the 19 samples extracted with methanol were carried out and shown in Figure 1.…”

Section: Principal Component Analysis (Pca)mentioning

confidence: 99%

Quality Control Methodology and Their Application in Analysis on HPLC Fingerprint Spectra of Herbal Medicines

Zou

Zhang

et al. 2012

Chromatography Research International

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As traditional Chinese medicine (TCM) is gradually accepted by many countries, people pay much attention to the quality of herbal medicines. Because of the significant variation in active components in them, the quality control of herbal medicines is a very important issue. Nowadays, high-performance liquid chromatography (HPLC) fingerprint spectra (FPS) are widely used in identification and quality control of herbal medicines. This paper will analyze the methodology and their application in identifying and evaluating herbal medicines by means of HPLC FPS, which includes simple comparing, clustering, principal component analysis (PCA), and similarity analysis methods.

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Chromatographic fingerprint analysis—a rational approach for quality assessment of traditional Chinese herbal medicine

Cited by 411 publications

References 2 publications

Chromatographic fingerprint analysis for evaluation of Ginkgo biloba products

Chromatographic fingerprint analysis for evaluation of Ginkgo biloba products

Chromatographic Fingerprint Analysis and Characterization of Constituents in Shenqi Fuzheng Injection by HPLC-DAD-ELSD and UFLC-DAD-Q-TOF Tandem Mass Spectrometry Techniques

Quality Control Methodology and Their Application in Analysis on HPLC Fingerprint Spectra of Herbal Medicines

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