Chromium(III)-insulin derivatives and their implication in glucose metabolism

Govindaraju, K.; Ramasami, T.; Ramaswamy, D.

doi:10.1016/0162-0134(89)80006-6

Cited by 31 publications

(15 citation statements)

References 18 publications

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“…A literature survey indicates that many studies investigated the Cr 3þ : Glu system without reporting stability constants in aqueous solutions [37][38][39][40]. Stability constants are crucial estimates to understanding the stabilities of metal species [6].…”

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confidence: 99%

Equilibrium models of Cr³⁺ and Cu²⁺ with glutamate

Hamada

Holyfield

Rosli

et al. 2009

Journal of Coordination Chemistry

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Speciation diagrams and stability constants for glutamate (Glu) with (Cr 3þ ) and (Cu 2þ ) in aqueous solutions are presented. The current study covers a larger pH-range affording accurate results, and reveal a different set of species for Cu 2þ and species not previously reported for Cr 3þ . For the Cu 2þ : Glu system, the most successful model that refined the potentiometric data contains the simple one-to-one complex, the bis-complex and the mono-hydroxo complex. The overall stability constants for Cu 2þ -Glu complexes have respective values of log 110 ¼ 7.6 AE 0.2, log 11-1 ¼ 1.3 AE 0.7, log 120 ¼ 13.6 AE 0.2. Attempts to refine the stability constant for the mono-protonated metal complex (log 111 ) that was reported in the literature indicated that this mono-protonated species did not form to an appreciable amount to be important for the model presented here. For the Cr 3þ : Glu system, the overall stability constants for the complexes formed have the values of log 110 ¼ 8.34 AE 0.03, log 11-1 ¼ 1.9 AE 0.1 and log 11-2 ¼ À4.6 AE 0.1. These results for Cr 3þ system covers wider pH-range and have more accuracy than those reported previously. The NMR experiments for Glu revealed downfield shifts of all protons as pH values decrease from 11.21 to 2.85.

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confidence: 99%

Equilibrium models of Cr³⁺ and Cu²⁺ with glutamate

Hamada

Holyfield

Rosli

et al. 2009

Journal of Coordination Chemistry

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“…A chromium(III) Schiff base complex bearing a tetradentate ligand, [Cr(salen)(OH 2 ) 2 ] þ (Scheme 1), has been shown to lower the blood glucose and plasma triglyceride levels in diabetic rats [11]. On the other hand, it has also been shown that [Cr(salen)(OH 2 ) 2 ] þ brings about certain cytotoxic and genotoxic effects on some cellular and microbial systems [12,13].…”

Section: Resultsmentioning

confidence: 99%

“…For instance, even at the prokaryotic level, chromic chloride has been shown to maintain the glucose levels in the yeast, Saccharomyces cerevisiae [10]. On the similar scale of significance, a Schiff base complex of chromium(III), [Cr(salen)(OH 2 ) 2 ] þ , was found to enhance insulin activity and insulin derivatised with the same was found to exhibit higher activity in glucose metabolism in animal models when compared to either free insulin or other derivatives [11]. On the other hand, [Cr(salen)(OH 2 ) 2 ] þ has been shown to elicit mutagenic response in TA 97A, …”

Section: Introductionmentioning

confidence: 99%

A Schiff base complex of chromium(III): an efficient inhibitor for the pathogenic and invasive potential of Shigella dysenteriae

Shrivastava

Devaraj

Nair

2004

Journal of Inorganic Biochemistry

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“…Cr facilitates insulin binding to the cells by increasing the number of insulin receptors. Cr has been reported to inhibit oxidative stress [62] and causes the stabilization of insulin and insulin receptor through metal sulfur bonding [63,64].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Hypoglycemic Activity of Inorganic Constituents in Nelumbo nucifera Seeds on Streptozotocin-Induced Diabetes in Rats

Mani

Subramanian

Pillai

et al. 2010

Biol Trace Elem Res

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The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic properties of seed ash on streptozotocin-induced diabetes in rats. Diabetic rats treated with lotus seed ash at a concentration of 200 mg/kg body weight orally for 30 days exhibited significant hypoglycemic activity. The presence of trace elements in appreciable amounts in the seeds may play a direct or indirect role on insulin secretion or its action in a synergetic manner. The hypoglycemic activity of the ash was comparable with glyclazide. The role of trace elements in disorders related to diabetes is also discussed briefly.

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Chromium(III)-insulin derivatives and their implication in glucose metabolism

Cited by 31 publications

References 18 publications

Equilibrium models of Cr³⁺ and Cu²⁺ with glutamate

Equilibrium models of Cr³⁺ and Cu²⁺ with glutamate

A Schiff base complex of chromium(III): an efficient inhibitor for the pathogenic and invasive potential of Shigella dysenteriae

Evaluation of Hypoglycemic Activity of Inorganic Constituents in Nelumbo nucifera Seeds on Streptozotocin-Induced Diabetes in Rats

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Chromium(III)-insulin derivatives and their implication in glucose metabolism

Cited by 31 publications

References 18 publications

Equilibrium models of Cr3+ and Cu2+ with glutamate

Equilibrium models of Cr3+ and Cu2+ with glutamate

A Schiff base complex of chromium(III): an efficient inhibitor for the pathogenic and invasive potential of Shigella dysenteriae

Evaluation of Hypoglycemic Activity of Inorganic Constituents in Nelumbo nucifera Seeds on Streptozotocin-Induced Diabetes in Rats

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Equilibrium models of Cr³⁺ and Cu²⁺ with glutamate

Equilibrium models of Cr³⁺ and Cu²⁺ with glutamate