Chromodomain Y-like Protein–Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors

Liu, Yongqing; Li, Minghua; Fan, Minghua; Song, Yu; Yu, Huajing; Zhi, Xiaojie; Xiao, Kuo; Lai, Shaoyong; Zhang, J.; Jin, Xin; Shang, Yongfeng; Liang, Jing; Huang, Zhuo

doi:10.1016/j.biopsych.2018.11.025

Cited by 80 publications

(95 citation statements)

References 55 publications

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“…Histone crotonylation was found decreased in the medial prefrontal cortex of susceptible rodents exposed to chronic social defeat stress . In addition, when knocking down CDYL in prelimbic cortex, the histone crotonylation was increased.…”

Section: Functional Roles Of Lysine Crotonylationmentioning

confidence: 93%

“…Histone crotonylation was found decreased in the medial prefrontal cortex of susceptible rodents exposed to chronic social defeat stress. 42 In addition, when knocking down CDYL in prelimbic cortex, the histone crotonylation was increased. Using ChIP-quantitative 36 PCR, this finding also demonstrated that CDYL inhibits VGF transcription by its dual influence on histone crotonylation and H3K27me3 of VGF promoter.…”

Section: Regulation Of Depressionmentioning

confidence: 99%

“…In vivo Interventional study Mice model 2018 42 Regulation of telomere maintenance Cell culture Interventional study MEF cells 2018 44 Regulation of HIV latency Cell culture Interventional study J-Lat A1 and CD4 + T cells 2018 47 Regulation of cancer In vivo and cell culture Interventional study HCC tissues and human hepatoma-derived cell 2019 51 In general, one protein may occur simultaneously multiple PTMs. 53 Indeed, recent years gradually intensifying research on crotonylation and many publications were dedicated to only one of the many possible lysine crotonylations.…”

Section: Regulation Of Depressionmentioning

confidence: 99%

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Functions and mechanisms of lysine crotonylation

Wan

Chu

et al. 2019

J Cellular Molecular Medi

103

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Lysine crotonylation is a newly discovered post‐translational modification, which is structurally and functionally different from the widely studied lysine acetylation. Recent advances in the identification and quantification of lysine crotonylation by mass spectrometry have revealed that non‐histone proteins are frequently crotonylated, implicating it in many biological processes through the regulation of chromatin remodelling, metabolism, cell cycle and cellular organization. In this review, we summarize the writers, erasers and readers of lysine crotonylation, and their physiological functions, including gene transcription, acute kidney injury, spermatogenesis, depression, telomere maintenance, HIV latency and cancer process. These findings not only point to the new functions for lysine crotonylation, but also highlight the mechanisms by which crotonylation regulates various cellular processes.

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Section: Functional Roles Of Lysine Crotonylationmentioning

confidence: 93%

Section: Regulation Of Depressionmentioning

confidence: 99%

Section: Regulation Of Depressionmentioning

confidence: 99%

See 1 more Smart Citation

Functions and mechanisms of lysine crotonylation

Wan

Chu

et al. 2019

J Cellular Molecular Medi

103

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“…Some evidence indirectly showed that histone crotonylation may plays role in neuronal maturation and migration. First, chromodomain Y‐like Protein (CDYL) was a crotonyl‐CoA hydratase and histone crotonylation can be negatively regulated by CDYL (Liu et al, 2019). The evidence showed that CDYL is essential for neuronal migration, which is dependent on the association between CDYL and chromatin histones, and knocking down CDYL caused abnormal neuronal migration (Qin et al, 2017).…”

Section: Crotonylationmentioning

confidence: 99%

“…There have been some studies about the function of histone crotonylation in the central nervous system. Recently, it was verified that aberrant histone crotonylation was distinctly connected with stress-induced depressive behaviors (Liu et al, 2019). However, the mechanisms underlying histone crotonylation related to the aberrant neuroanatomical structures in BTBR mice have not been published.…”

Section: Crotonylationmentioning

confidence: 99%

Elevated lysine crotonylation and succinylation in the brains of BTBR mice

Wang

Chang

Yang

et al. 2019

Intl J of Devlp Neuroscience

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The BTBR T + Itpr3tf/J (BTBR) mouse has developmental disorders in the central nervous system and many aberrant neuroanatomical structures. However, identification of the pathological mechanisms underlying these abnormal neuroanatomical structures in the brains of BTBR mice is still lacking. Posttranslational modifications (PTMs) are known to be involved in the regulation of diverse cellular processes, and evidence shows that some types of PTMs are associated with the development of the central nervous system. In this study, we detected four novel PTMs in the cerebral cortex of BTBR mice as compared to C57BL/6 J (B6) mice using western blotting. Results revealed that lysine crotonylation and succinylation were elevated in the cerebral cortex of BTBR mice compared to levels in B6 mice. We speculate that elevated profiles of lysine crotonylation and succinylation may be involved in mechanisms related to neuroanatomical abnormalities in cerebral cortex of BTBR mice.

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Dysmyelination by Oligodendrocyte‐Specific Ablation of Ninj2 Contributes to Depressive‐Like Behaviors

Sun

Chen

et al. 2021

Advanced Science

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Depression is a mental disorder affecting more than 300 million people in the world. Abnormalities in white matter are associated with the development of depression. Here, the authors show that mice with oligodendrocyte-specific deletion of Nerve injury-induced protein 2 (Ninj2) exhibit depressive-like behaviors. Loss of Ninj2 in oligodendrocytes inhibits oligodendrocyte development and myelination, and impairs neuronal structure and activities. Ninj2 competitively inhibits TNF𝜶/TNFR1 signaling pathway by directly binding to TNFR1 in oligodendrocytes. Loss of Ninj2 activates TNF𝜶-induced necroptosis, and increases C-C Motif Chemokine Ligand 2 (Ccl2) production, which might mediate the signal transduction from oligodendrocyte to neurons. Inhibition of necroptosis by Nec-1s administration synchronously restores oligodendrocyte development, improves neuronal excitability, and alleviates depressive-like behaviors. This study thus illustrates the role of Ninj2 in the development of depression and myelination, reveals the relationship between oligodendrocytes and neurons, and provides a potential therapeutic target for depression.

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Chromodomain Y-like Protein–Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors

Cited by 80 publications

References 55 publications

Functions and mechanisms of lysine crotonylation

Functions and mechanisms of lysine crotonylation

Elevated lysine crotonylation and succinylation in the brains of BTBR mice

Dysmyelination by Oligodendrocyte‐Specific Ablation of Ninj2 Contributes to Depressive‐Like Behaviors

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