Chromone derivatives which bind to human hair

Walenzyk, Thomas; Carola, Christophe; Buchholz, Herwig; König, Burkhard

doi:10.1016/j.tet.2005.05.081

Cited by 34 publications

(14 citation statements)

References 42 publications

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“…The works performed in this field are mainly related with ester formation (e.g. methyl and ethyl esters) [231] or acyl halides as intermediates for the synthesis of chromone carboxamides [290] finally by reaction with several substituted amines will afford the correspondent aminoalkyl chromones. [291] .…”

Section: Synthesis Of Chromones From Other Chromonesmentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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The last few decades have provided stunning progresses in the understanding of physiopathology of several diseases. The remarkable progress in research fields, like genetics, immunology, neurobiology, among others, as well as the advent of more powerful tools, have made it possible to characterize, monitor, and understand far more of the basis of physiology and disease. However, for some diseases the treatment remains a problematic issue as the efforts performed so far were not translated into therapeutic solutions. Notwithstanding the steady increase in the total amount of FCUP

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Section: Synthesis Of Chromones From Other Chromonesmentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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“…Schiff bases obtained by the condensation of amino and carbonyl compounds are intrinsic class of ligand that coordinate to metal ions via azomethine nitrogen and have been extensively for its wide range of medicinal applications. Chromone derivatives attract chemist due to various medicinal applications such as antimicrobial, antifungal, antimycobacterial, antiallergenic, antihypertensive, anticonvulsant, anticancer, antioxidant, antiinflammatory, proteinkinase C inhibitors and mushroom tyrosinase inhibition activities [1][2][3][4][5] . Omnipresent occurrence of chromone particularly in plants and their less toxicity towards mammals, also human diet contains huge chromone derivatives [6][7] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antimicrobial Screening Studies of Some Metal Complexes of Novel Schiff Base of 3-Formyl-6-Methylchromone and 3-Aminoquinoline

Ghumbre¹,

Ujgare²,

Borude³

et al. 2018

Int Res J Pharm

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Synthesis of Ni(II) and Fe(III) complexes with Schiff base 6-methyl-3-((quinolin-3-ylimno) methyl)-4H-chromen-4-one obtained from 3-formyl-6methylchromone and 3-aminoquinoline.Schiff base and its complexes were characterized by analytical data, elemental analysis, molar conductance, thermogravimetric analysis. The structural investigation performed by UV-Vis, IR and 1 HNMR spectral techniques. Interpretation of elemental analysis shown 2:1 molar ratio of Schiff base with metal complexes. Molar conductance values indicate neutral nature of metal complexes. Antimicrobial activity studied at different concentration (MIC method) by disc diffusion technique. Schiff base and the metal complexes found to be significant antibacterial and antifungal agents.

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“…Chromones have a wide range of biological activities including tyrosine and protein kinase C inhibitors, antiallergic, antiviral, antitublin, antihypertensive as well being active at benzoazepine receptors, lipoxygenase, and cyclooxygenase and modulating P-glycoprotein-mediated multidrug resistance [24,25]. Chromone derivatives are essential for the synthesis of many important oxygen heterocycles such as pyrazoles and xanthones [26].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, DNA Binding, DNA Cleavage and Antimicrobial Studies of Schiff Base Ligand and its Metal Complexes

Padmaja¹,

Kumari

Ragi

2015

J Fluoresc

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A series of Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) complexes have been synthesized from the Schiff base ligand L. The Schiff base ligand 4-chloro-2-((4-oxo-4H-chromen-3yl) methylene amino) benzoic acid (L) has been synthesized by the reaction between chromone-3-carbaldehyde and 4-chloro-2-amino benzoic acid. The nature of bonding and geometry of the transition metal complexes as well as ligand L have been deduced from elemental analysis, FT-IR, UV-vis, (1)H NMR, (13)C NMR, ESR spectral studies, mass, magnetic susceptibility and molar conductance measurements. The complexes are found to have ML2 composition and are neutral in DMSO. Based on elemental, conductance and spectral studies, six-coordinated geometry was assigned for these complexes. The ligand L acts as tridentate and coordinates through nitrogen atom of azomethine group, hydroxyl of the carboxyl group and oxygen atom of keto group of γ-pyrone ring. The interaction of Cu(II) complex with CT-DNA was carried out by UV-vis, fluorescence titrations and viscosity measurements. The complex binds to DNA through intercalative binding mode. The nuclease activity of the above metal complexes shows that Cu(II) and Co(II) complexes cleave DNA through redox chemistry. The biological activity of the ligand and its complexes have been studied on four bacteria E. coli, B. subtilis, pseudomonas and Edwardella and two fungi penicillium and trichoderma by well disc and fusion method and found that the metal complexes are more active than the free Schiff base ligand.

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Chromone derivatives which bind to human hair

Cited by 34 publications

References 42 publications

Chromone: A Valid Scaffold in Medicinal Chemistry

Chromone: A Valid Scaffold in Medicinal Chemistry

Synthesis, Characterization and Antimicrobial Screening Studies of Some Metal Complexes of Novel Schiff Base of 3-Formyl-6-Methylchromone and 3-Aminoquinoline

Synthesis, Characterization, DNA Binding, DNA Cleavage and Antimicrobial Studies of Schiff Base Ligand and its Metal Complexes

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