Chromosomal abnormalities in couples undergoing intracytoplasmic sperm injection. A study of 370 couples and review of the literature

Abstract

SummaryIntracytoplasmic sperm injection (ICSI) is now widely acknowledged as the most effective therapeutic approach to severe male infertility or unsuccessful in vitro fertilization. Cytogenetic investigations were performed in 370 females and 335 males prior to ICSI between January 1997 and April 2003. Nine men (2.7%) and 48 women (13%) had an abnormal karyotype, 44 females having some degree of numerical sex chromosome mosaicism. A review of the literature showed the prevalence of all types of chromosomal abnormalities to be much higher among male and female partners of couples examined prior to ICSI than among newborns. As most ICSIs are performed with ejaculated spermatozoa from oligospermic men, the distribution and the prevalence of the several types of chromosomal abnormalities are closer to those of oligospermic rather than azoospermic males. Our results combined with those of the literature stress the importance of karyotyping both male and female partners before ICSI is started. Adequate genetic counselling, possibly followed by prenatal diagnosis, should be offered if a chromosomal anomaly is detected.

Cytogenetic abnormalities in 179 cases with male infertility in Western Region of Turkey: Report and review

“…Evaluation of 15 similar studies from the literature including a total of 9374 cases showed 6.54% chromosomal anomaly rate (Table 3) [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In our study 11.74% of all cases revealed chromosomal alteration including inv (9).…”

Chromosome heteromorphisms: an impact on infertility

“…Chromosome analyses have been studied in large groups of infertile patients in recent years [3][4][5][11][12][13]. In some of these studies, chromosome heteromorphisms were reported to have a higher frequency than the normal population and were regarded as abnormalities [4,5,13].…”

Chromosomal Heteromorphisms and Karyotype Abnormalities in Humans

“…Chromosome analyses have been studied in large groups of infertile patients in recent years (Cortes-gutrienez et al, 2004;Nakamura et al, 2001;Yakin et al, 2005;Morel et al, 2004;Lissitsina et al, 2006;Madon et al, 2005). In some of these studies, chromosome heteromorphisms were reported to have a higher frequency than the normal population and were regarded as abnormalities (Nakamura et al, 2001;Yakin et al, 2005;Madon et al, 2005).…”