2013
DOI: 10.5271/sjweh.3358
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Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Abstract: We report significantly increased chromosomal damage among medical staff occupationally exposed to various genotoxic compounds in several medical professions. Potentially harmful exposures in hospital environment represent considerable health risk, since chromosomal aberrations have been found to be predictive of cancer risk, and an association between chromosomal damage and cancer risk has been shown. Affiliation:

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Cited by 49 publications
(36 citation statements)
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“…The study design was approved by the local Ethical Committee of the Jessenius Medical Faculty and participants provided an informed consent. Cytogenetic analysis was performed on cultured lymphocytes, as previously described, by microscopically analyzing (two microscopists) in a double-blind fashion coded slides of 100 metaphases per person for the frequency of total CAs, CTAs, and CSAs (Vodicka et al, 2010;Musak et al, 2013). For this study, subjects were selected based on the CA score: no CAs, more than two CAs, only CSAs (median 2) or only CTAs (median 2).…”
Section: To the Editormentioning
confidence: 99%
“…The study design was approved by the local Ethical Committee of the Jessenius Medical Faculty and participants provided an informed consent. Cytogenetic analysis was performed on cultured lymphocytes, as previously described, by microscopically analyzing (two microscopists) in a double-blind fashion coded slides of 100 metaphases per person for the frequency of total CAs, CTAs, and CSAs (Vodicka et al, 2010;Musak et al, 2013). For this study, subjects were selected based on the CA score: no CAs, more than two CAs, only CSAs (median 2) or only CTAs (median 2).…”
Section: To the Editormentioning
confidence: 99%
“…Coincidently, Musak et al showed that healthcare personnel exposed to volatile anesthetics exhibit higher frequency of chromosomal damage [6]. These findings imply direct carcinogenic effects of inhaled anesthetic agents, making the issue of perioperative tumor progression an even more complex matter.…”
Section: The Effect Of General Anesthesia On Cancer Recurrencementioning
confidence: 94%
“…About 57% of these individuals were exposed to some form of genotoxins due to the nature of their professions and their exposure was assessed by personal dosimeters, the rest were office workers and local residents; 30% were self‐reported smokers (Table ). The genotoxic substances included mainly small organic compounds, such as vinyl chloride, epichlorohydrine and ethylene oxide, anesthetics, heavy metals and styrene (Vodicka et al , b, , Musak et al , ). The replication was conducted on two different sample sets.…”
Section: Methodsmentioning
confidence: 99%
“…Staining of slides was carried out using 5% Giemsa‐Romanowski solution for 5 min. Cultured PBLs were analyzed in metaphase stage under a light microscope (Dušinská et al ; Kažimírová et al ; Musak et al ). For each person, 100 mitoses were analyzed in a double‐blind fashion and the frequency of different types of CAs (CSAs, CTAs) was recorded (Vodicka et al ; Musak et al ).…”
Section: Methodsmentioning
confidence: 99%