Chromosome and sister chromatid exchange studies in Behcet's patients

Abstract

Behcet's disease is a chronic multisystemic disease of unknown pathogenesis characterized by four major symptoms: oral aphthous ulcers, skin lesions, ocular symptoms and genital ulcerations. The disease is spread throughout the world, but it is most frequent in Turkey, Japan, Korea and China. Although HLA-Bw51 has been found to predominate in Behcet's cases, the genetic etiology has not yet been clarified. In this study, we investigated the chromosomal abnormalities and sister chromatid exchange rates in patients with Behcet's diseases. Thirty-eight patients with Behcet's disease (diagnosed for the first time) and 30 healthy subjects (as controls) were included in this study. Although numerical and structural chromosomal abnormalities were not detected in our patients, we found an increased rate of sister chromatid exchange in patients over the control groups (P < 0.01). On the basis of these results, we discuss the genetic etiology of Behcet's disease.

Assessment of genotoxicity associated with Behcet’s disease using sister-chromatid exchange assay: vitamin E versus mitomycin C

“…Behcet's disease has been shown to be associated with genotoxicity as measured by cytogenetic and oxidative DNA damage assays. For example, elevation in sister chromatid exchange (SCE) in BD lymphocytes has been shown by several reports (Ikbal et al 2006;Karaman et al 2009;Oztas et al 2006;Sonmez et al 1998). The increase in the SCE rate was evident in patients with active and inactive episodes (Karaman et al 2009) and in patients typed positive or negative for HLA-B51allele (Ikbal et al 2006).…”

Cell Cycle Kinetics and Sister Chromatid Exchange in Mosaic Turner Syndrome

“…A higher incidence of sister chromatid exchange (SCE) can be associated with CIN, as is seen in some cancers and congenital syndromes [12][13][14][15][16]. Therefore, SCE has been used as a sensitive indicator of spontaneous CIN [12,[17][18][19][20]. Previous research has reported high SCE incidences in patients with Bloom syndrome, Werner syndrome, and various types of neoplasia [12,13,20].…”

Genotoxic effect of albendazole in pediatric patients with hepatic hydatid disease

“…Various physical and chemical agents and some idiopathic disorders have an increasing effect on frequencies of SCE. [12][13][14][15][16][17][18] The micronucleus (MN) frequency has also been used to determine genotoxicity on the human genome. The MN frequency is considered a direct indicator of numerical and structural chromosome damage.…”