Chromosomes in Cleft-Palate Tissues

Murphy, J.W.; Reisman, Leonard E.

doi:10.1016/s0140-6736(66)92515-3

The Lancet

1966

DOI: 10.1016/s0140-6736(66)92515-3

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Chromosomes in Cleft-Palate Tissues

J.W. Murphy¹,

Leonard E. Reisman²

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1966

2008

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Cited by 4 publications

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Increased frequency of tetraploidy in cultured skin fibroblasts from extremities with reduction malformations

Annerén

2008

Hereditas

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A study was made of the frequency of polyploidy in fibroblast cultures from different types of reduction malformations. An increased frequency of tetraploid cells was found in skin cultures from biopsies taken from extremities with unilateral, longitudinal meromelia of unknown origin and from extremities with reduction malformation due to thalidomide embryopathy. The findings were compared with those in cultured fibroblasts from a healthy extremity in the same patient and from skin of non‐malformed patients. Other malformations such as cleft lip and palate, bilateral reduction malformations of the extremities and unilateral terminal, transverse meromelia of unknown origin showed no increase in tetraploidy frequency. The possible pathogenetic importance of the observation is discussed.

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Increased frequency of tetraploidy in cultured skin fibroblasts from extremities with reduction malformations

Annerén

2008

Hereditas

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Cytogenetic Studies of Normal and Cleft-Palate Epitheliums in Mice

et al. 1969

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Cytogenetic Analysis of Siamese Cats with Cleft Palate

Loevy

1974

J Dent Res

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Chromosomes in Cleft-Palate Tissues

Cited by 4 publications

References 7 publications

Increased frequency of tetraploidy in cultured skin fibroblasts from extremities with reduction malformations

Increased frequency of tetraploidy in cultured skin fibroblasts from extremities with reduction malformations

Cytogenetic Studies of Normal and Cleft-Palate Epitheliums in Mice

Cytogenetic Analysis of Siamese Cats with Cleft Palate

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