Chronic Ear Infection in the Immunodeficient Patient

Sasaki, Clarence T.; Askenase, Philip W.; Dwyer, J. G.; Yanagisawa, Eiji

doi:10.1001/archotol.1981.00790380012004

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Bacterial culture of the ear discharge was carried out twice, but no bacterial growth was found. Peripheral blood examination showed no anemia; and the WBC count was 11,500/cu mm, with 60.5% segmented polymorphonuclear leu¬ kocytes, 8.5% band leukocytes, 16 Antibody activities to measles, mumps, and polio viruses were negative at four times dilution in each instance. Activity to anti-A, anti-B isoagglutinin was negative; to antistreptolysin, it was negative at two times dilution; and heterophile antibodies to sheep RBCs were positive at 32 times dilution.…”

Section: Report Of a Casementioning

confidence: 96%

Recurrent Otitis Media in Association With Immunodeficiency

Mogi¹,

Maeda²

1982

Archives of Otolaryngology - Head and Neck Surgery

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Background & Purpose: Recurrent and chronic infections of the ear, throat and nose are one of the most important health problems worldwide, and they clearly affect the quality of life in adults and children. In spite of proper diagnosis and proper treatment, groups of these patients do not respond to routine treatment and are still being symptomatic and have chronic complications in these patients. Various studies have shown that the immune system is defective in some patients with frequent and chronic infections of the ear, throat and nose. Therefore, the present study was conducted to evaluate the relative frequency of primary immunodeficiency diseases in children with sinusitis and recurrent middle ear infections. Methods & Materials: This study evaluated underlying immune defects in patients with otitis media or recurrent sinusitis. Serum levels of IgA, IgG and IgM were evaluated by nephlometric test. In addition, a complete count of blood cells was also evaluated. The rate of humoral response to diphtheria and tetanus was also assessed. NBT was used to evaluate the immune system. Results: Out of 62 patients, 12 patients (19%) had defects in at least one antibody class. Five patients with IgA deficiency (which 2 of them have also showed IgG concurrent deficiency) were seen. Also, 4 patients had IgG deficiency and 3 patients showed IgM deficiency. None of the patients had abnormal cell count. NBT response was also normal in all patients. Conclusion:In general, the findings of the present study in line with previous studies showed that a large proportion of children with recurrent otitis media and sinusitis have abnormal immunologic function. Therefore, it is recommended that the evaluation of immune deficiency be considered in these patients.

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Section: Report Of a Casementioning

confidence: 96%

Recurrent Otitis Media in Association With Immunodeficiency

Mogi¹,

Maeda²

1982

Archives of Otolaryngology - Head and Neck Surgery

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“…16 They also have an increased incidence of diarrhea and other intestinal disor¬ ders1·2 as well as autoimmune dis¬ eases, eg, rheumatoid arthritis and systemic lupus erythematosus. [1][2][3][4][5][6] In the present study, the appear¬ ance of recurrent purulent upper respiratory tract infection (URTI) in adult patients with common variable immunodeficiency and selective IgA deficiency was investigated. Particu¬ lar attention was paid to infections of the nose and paranasal sinuses and to the relationship between URTI and lower respiratory tract infection (LRTI) with respect to the time of onset of symptoms, indicating the appearance of the antibody defi¬ ciency.…”

mentioning

confidence: 99%

Infections of the Nose and Paranasal Sinuses in Adult Patients With Immunodeficiency

Karlsson¹,

Petruson²,

Björkander³

et al. 1985

Archives of Otolaryngology - Head and Neck Surgery

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Immunodeficiency diseases: Head and neck manifestations

Harris

South

1982

Head Neck

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Infections of the upper respiratory tract are common to both the immunodeficient and the normal child during their development. The most common head and neck manifestations of immunodeficiency disease are recurrent suppurative otitis media, tonsillitis, sinusitis, rhinitis, and nasopharyngitis. Often the head and neck specialist is confronted with a child with one or more of these problems and must institute the appropriate therapy or decide on an avenue for further investigation. This paper outlines the major immunodeficiency state, discusses the immune defects thought to be responsible for the spectrum of clinical findings, and suggests a systematic approach to the evaluation of these difficult diseases. The recognition of immunodeficient individuals is an important step in their treatment so that adjunctive immunological therapy can be provided.

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Chronic Ear Infection in the Immunodeficient Patient

Cited by 8 publications

References 11 publications

Recurrent Otitis Media in Association With Immunodeficiency

Recurrent Otitis Media in Association With Immunodeficiency

Infections of the Nose and Paranasal Sinuses in Adult Patients With Immunodeficiency

Immunodeficiency diseases: Head and neck manifestations

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