Chronic exposure to aluminum reduces tyrosine hydroxylase expression in the substantia nigra and locomotor performance in rats

Erazi, Hasna; Ahboucha, Samir; Gamrani, Halima

doi:10.1016/j.neulet.2010.09.053

Cited by 25 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wang et al (2010a) concluded that ingestion of AlCl 3 reduced memory, impaired hippocampal synaptic plasticity, and decreased LTP induction-related kinases MAPK, ERK1/2, and CAMKII. As in studies by Erazi et al (2011) and Thirunavukkarasu et al (2012), the pH of the drinking water was not reported and no concurrent controls given equimolar concentrations of HCl were included.…”

Section: Organ Systems and Functionmentioning

confidence: 99%

“…Only Akiyama et al (2011) and Ribes et al (2010, 2011) provided a rationale for duration of exposure and some (González-Muñoz et al 2008a, 2008b) lacked concurrent vehicle controls. Many of these studies used a single level of Al (administered as the chloride or lactate) and examined sexually mature male or female rats (Erazi et al 2011, Kumar et al 2011, Thirunavukkarasu et al 2012) or mice (Kakkar and Kaur 2011, Xiao et al 2011). Cui et al (2012) and Wang et al (2010a) studied young rodents; Abu-Taweel et al (2011a, 2011b), Abd El-Rahman et al (2011), Kakkar and Kaur (2011), and Xiao et al (2011) studied mature mice.…”

Section: Organ Systems and Functionmentioning

confidence: 99%

“…The majority of these studies gave Al via gavage (Abu-Taweel et al 2011, Ahmed et al 2011, Belaid-Nouria et al 2012, Bihaqi et al 2009, Kakkar and Kaur 2011, Kumar et al 2011, Thirunavukkarasu et al 2012, Xiao et al 2011) and others employed drinking water (Abd-Elghaffar et al 2007, Cui et al 2012, Wang et al 2010a); only two of the studies examined more than a single dose level (Cui et al 2012, Wang et al 2010a). Six of the recent studies presented measurements of Al in the brain and blood and included brain histology along with results of neurobehavioral testing (Chakrabarty et al 2012, Cui et al 2012, Erazi et al 2011, Kakkar and Kaur 2011, Kumar et al 2011, Wang et al 2010a). …”

Section: Organ Systems and Functionmentioning

confidence: 99%

“…Erazi et al (2011) evaluated the effects of AlCl 3 administration in drinking water at 0 or 0.3% (3000 mg/L) among four groups of five male and female Wistar rats in two separate protocols. In the first study, rats were given AlCl 3 beginning at 3 months of age and this continued for 4 months.…”

Section: Hepaticmentioning

confidence: 99%

“…Prenatal, lactational, and perinatal exposure of rats to AlCl 3 reduced the numbers of TH reactive neurons within the substantia nigra, reduced immunostaining in the substantia nigra and reduced locomotor activity in the offspring. Erazi et al (2011) suggested that Al-associated changes in neurologic parameters were more pronounced in rats exposed to AlCl 3 from conception to maturity compared to rats given AlCl 3 as adults.…”

Section: Hepaticmentioning

confidence: 99%

See 4 more Smart Citations

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

338

201

View full text Add to dashboard Cite

Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability.Address for correspondence: Calvin C. Willhite, Risk Sciences International, 55 Metcalfe Street, Suite 700, Ottawa, ON, Canada. calvinwillhite@hotmail.com. Declaration of interestPartial funding for this work was provided by a contract to review the recent scientific literature on health effects of aluminum between the International Aluminium Institute (IAI, www.world-aluminium.org), the Aluminium Reach Consortium (ARC, www.aluminium-reach-consortium.eu), and Risk Sciences International (RSI, www.risksciences.com), a Canadian company established in 2006 in partnership with the University of Ottawa. Additional financial support was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) to D. Krewski, who holds the NSERC Chair in Risk Science at the University of Ottawa. C.C. Willhite, N.A. Karyakina, F. Momoli, and N. Yenugadhati were compensated by RSI for their contributions to the review. I. Arnold, T. Wisniewski and R. Yokel received no compensation from RSI for their contributions to this work. The authors, whose affiliations are shown on the title page, had sole responsibility for preparation of this paper, including determining the strategy for reviewing the scientific literature summarized in this article, synthesizing the findings, and drawing conclusions. Scientists associated with IAI/ARC were given the opportunity to review and offer technical comments on the paper, prior to submission to Critical Reviews in Toxicology. I. Arnold serves as a consultant to the International Aluminium Institute. None of the authors have appeared before regulatory agencies on behalf of the sponsors, or appeared as experts in legal proceedings concerning matters reviewed in this paper. The scientific opinions and conclusions expressed in the paper are exclusively those of the authors, and are independent of the sources of financial support. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptThe present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007). The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.

show abstract

Section: Organ Systems and Functionmentioning

confidence: 99%

Section: Organ Systems and Functionmentioning

confidence: 99%

Section: Organ Systems and Functionmentioning

confidence: 99%

Section: Hepaticmentioning

confidence: 99%

Section: Hepaticmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

338

201

View full text Add to dashboard Cite

show abstract

Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride‐induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO‐1/NF‐κB signaling

Alsharif

Albrakati

omairi

et al. 2022

Environmental Toxicology

View full text Add to dashboard Cite

Prodigiosin (PDG) is a bacterial metabolite with numerous biological and pharmaceutical properties. Exposure to aluminium is considered a root etiological factor in the pathological progress of Alzheimer's disease (AD). Here, in this investigation, we explored the neuroprotective potential of PDG against aluminium chloride (AlCl 3 )mediated AD-like neurological alterations in rats. For this purpose, rats were gavaged either AlCl 3 (100 mg/kg), PDG (300 mg/kg), or both for 42 days. As a result of the analyzes performed on the hippocampal tissue, it was observed that AlCl 3 induced biochemical, molecular, and histopathological changes like those related to AD. PDG pre-treatment significantly decreased acetylcholinesterase activity and restored the levels of brain-derived neurotrophic factor, monoamines (dopamine, norepinephrine, and serotonin), and transmembrane protein (Na + /K + -ATPase). Furthermore, PDG boosted the hippocampal antioxidant capacity, as shown by the increased superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione

show abstract

Allicin ameliorates aluminium- and copper-induced cognitive dysfunction in Wistar rats: relevance to neuro-inflammation, neurotransmitters and Aβ(1–42) analysis

et al. 2021

View full text Add to dashboard Cite

Chronic exposure to aluminum reduces tyrosine hydroxylase expression in the substantia nigra and locomotor performance in rats

Cited by 25 publications

References 19 publications

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride‐induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO‐1/NF‐κB signaling

Allicin ameliorates aluminium- and copper-induced cognitive dysfunction in Wistar rats: relevance to neuro-inflammation, neurotransmitters and Aβ(1–42) analysis

Contact Info

Product

Resources

About