Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome

Berg, David E.; Berg, Leonard H van den; Couvaras, J; Harrison, Holly

doi:10.1097/00001721-199910000-00006

Cited by 38 publications

(29 citation statements)

References 8 publications

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“…Furthermore, only two previous studies have analyzed fibrinogen levels in FM. One reported increased levels of fibrinogen in patients with chronic fatigue syndrome and/or FM (Berg et al, 1999), but the other detected no differences in fibrinogen levels between FM patients and controls (Arihan et al, 2017). In the present study, both parameters presented a moderate effect size, indicating that the differences we observed between the groups may be meaningful.…”

Section: Coagulation Statecontrasting

confidence: 56%

“…Therefore, the aim of the present study was to investigate thrombosis-related parameters in FM patients, including blood-coagulation parameters, platelet indices, and RBC count. The few previous studies conducted in this area have reported conflicting results regarding these parameters in patients with FM in comparison to healthy subjects (Aktürk & Büyükavci, 2017;Alves et al, 2016;Arihan, Caglayan, Bayrak, Akinci, & Falkmarken, 2017;Berg, Berg, Couvaras, & Harrison, 1999;Elmas et al, 2016;Haliloglu, Carlioglu, Sahiner, Karaaslan, & Kosar, 2014;Milovanovic et al, 2016). Given the association between thrombosis and inflammation, we also evaluated the inflammatory markers neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR; Uslu et al, 2015) as thrombosisrelated parameters.…”

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confidence: 98%

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Are Patients With Fibromyalgia in a Prothrombotic State?

Molina

Moral

Rubia

et al. 2019

Biological Research For Nursing

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Objectives: The aim of this study was to investigate thrombosis-related parameters (blood coagulation parameters, platelet indices, red blood cell [RBC] count, and inflammatory markers) in patients with fibromyalgia (FM). Method: We carried out a case–control study with 35 women with FM and 12 age-matched healthy volunteers to analyze fibrinogen levels, prothrombin time, cephaline time, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), RBC count, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (PLR). Results: The results showed significantly increased fibrinogen levels ( p < .05), platelet count ( p < .05), PDW ( p = .059), RBC count ( p < .05), and PLR ( p < .05) in women with FM versus the healthy volunteers. Prothrombin time ( p < .05) and MPV ( p < .05) were significantly lower in patients with FM than in the controls. Conclusions: Elevated platelet and RBC counts, PDW values, and fibrinogen levels as well as decreased prothrombin time are all indicative of a prothrombotic state in FM patients, which may be enhanced by an increased inflammatory tone. This prothrombotic state may increase the risk of thrombosis-related cardiovascular disease in patients with FM.

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Section: Coagulation Statecontrasting

confidence: 56%

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confidence: 98%

Are Patients With Fibromyalgia in a Prothrombotic State?

Molina

Moral

Rubia

et al. 2019

Biological Research For Nursing

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“…Several different forms of fibrinogen (alpha and beta) were upregulated and associated with pain intensity (Table 3), as in the CWP cohort 28 . Increased levels of blood coagulation proteins, e.g., fibrinogen, thrombin, have earlier been found in patients with chronic fatigue syndrome and/or FM 48 . It was also one of the major proteins, together with haptoglobin, that was elevated in the FM studied by Ramírez-Tejero et al 31 .…”

Section: Discussionmentioning

confidence: 89%

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Wåhlén

Ernberg

Mannerkorpi

et al. 2020

Sci Rep

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Fibromyalgia (FM) is a complex pain condition where the pathophysiological and molecular mechanisms are not fully elucidated. The primary aim of this study was to investigate the plasma proteome profile in women with FM compared to controls. The secondary aim was to investigate if plasma protein patterns correlate with the clinical variables pain intensity, sensitivity, and psychological distress. Clinical variables/background data were retrieved through questionnaires. Pressure pain thresholds (PPT) were assessed using an algometer. The plasma proteome profile of FM (n = 30) and controls (n = 32) was analyzed using two-dimensional gel electrophoresis and mass spectrometry. Quantified proteins were analyzed regarding group differences, and correlations to clinical parameters in FM, using multivariate statistics. Clear significant differences between FM and controls were found in proteins involved in inflammatory, metabolic, and immunity processes. Pain intensity, PPT, and psychological distress in FM had associations with specific plasma proteins involved in blood coagulation, metabolic, inflammation and immunity processes. This study further confirms that systemic differences in protein expression exist in women with FM compared to controls and that altered levels of specific plasma proteins are associated with different clinical parameters.

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“…We have noted that symptoms of angina, impaired blood flow to the brain, and poor circulation to the legs often disappear with enzymatic treatment for cardiovascular conditions. The gentle, yet effective use of nattokinase for preventing cardiovascular diseases makes this an optimal choice from preventive and treatment perspectives ditions [33][34][35][36]50 . Combination with other anti coagulative therapies or drugs should be approached with great caution, however.…”

Section: Prevention and Treatment Of Heart Conditionsmentioning

confidence: 99%

Protecting Circulation with Enzyme Nutrition

Meruvu¹,

Vangalapati²

2011

Biosci., Biotechnol. Res. Asia

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Nattokinase was discovered in 1980 by Dr Hiroyuki Sumi, researcher at Chicago University after testing over 173 natural foods as potential thrombolytic agents, searching for a natural agent that could effectively dissolve thrombus allied with cardiac and cerebral infarction [43][44][45] . Nattokinase was discovered in Natto, a fermented cheese-like food that has been used in Japan for over 1000 year. Natto is a traditional Japanese food made of soybeans . To prepare the beans are cooked and then by the action of the bacterium Bacillus subtilis ssp. natto fermented 9, 17 . During this process is formed a slimy, stringy substance to the beans. In the traditional method of preparation are the bacteria from rice straw , into which the beans are wrapped 3 . In the modern manufacturing process, the bacteria cultures inoculated with beans, so that the use of rice straw is no longer necessary 21 . The botanical source for Nattokinase is Glycine max(L. )Merr. It appears as a yellow-white fine powder 22 . ABSTRACTCardiokinase is a potent fibrinolytic enzyme with the potential for fighting cardiovascular diseases, hence referred so often. It is extracted and highly purified from a traditional Japanese food called Natto which is made from fermented soybeans and is also called nattokinase. Improper blood clotting or failure of clots to properly dissolve can lead to serious health consequences. Thrombotic diseases typically include cerebral hemorrhage, cerebral infarction, cardiac infarction and angina pectoris, and also include diseases caused by blood vessels with lowered flexibility, including senile dementia and diabetes. Pharmacologically Cardiokinase has a safe profile as the key agent for restoration of vasculature health and cure of all thrombotic diseases. Cardiokinase also termed "super health food" has caused world wide attention not only for its unique flavor and rich nutrition, but also due to a variety of health functions.

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Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome

Cited by 38 publications

References 8 publications

Are Patients With Fibromyalgia in a Prothrombotic State?

Are Patients With Fibromyalgia in a Prothrombotic State?

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Protecting Circulation with Enzyme Nutrition

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