2018
DOI: 10.1111/odi.12936
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Chronic graft‐versus‐host disease: Current management paradigm and future perspectives

Abstract: Chronic GVHD is a serious disease which may be active for years, or even decades, requiring potentially years of immunosuppressive therapies and placing patients at risk for a number of late complications. While the oral cavity has long been recognized to be a prominent target of GVHD, and in particular, chronic GVHD, it must be recognized and appreciated that it is a complex systemic disease with a wide spectrum of clinical manifestations.

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Cited by 30 publications
(24 citation statements)
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References 189 publications
(242 reference statements)
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“…In this regard, it is interesting to note that, in our study, four of the seven patients who developed OSCC were the recipients of HLA-identical sibling transplants. It is known that the degree of HLA disparity is the key determinant for GVHD risk and, in second line, for the onset of cancer [ 27 ]; therefore, in our cases, the development of OSCC in patients with a full HLA match between donor and recipient is attributable to a pathogenetic mechanism not associated with donor cells.…”
Section: Discussionmentioning
confidence: 75%
“…In this regard, it is interesting to note that, in our study, four of the seven patients who developed OSCC were the recipients of HLA-identical sibling transplants. It is known that the degree of HLA disparity is the key determinant for GVHD risk and, in second line, for the onset of cancer [ 27 ]; therefore, in our cases, the development of OSCC in patients with a full HLA match between donor and recipient is attributable to a pathogenetic mechanism not associated with donor cells.…”
Section: Discussionmentioning
confidence: 75%
“…GVHD is a common and complex complication of allogeneic HSCT [4]. In patients with GVHD, a series of alloimmune reactions occur due to a mismatch in HLA antigens [5,6] leading to acute or chronic GVHD. Nowadays, the distinction between acute and chronic GVHD (cGVHD) is made based on clinical manifestations, rather than based on time after HSCT with a classic dividing line at 100 days [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Nowadays, the distinction between acute and chronic GVHD (cGVHD) is made based on clinical manifestations, rather than based on time after HSCT with a classic dividing line at 100 days [7,8]. Whereas acute GVHD typically presents specific clinical and histopathological features of the skin, liver, and/or gastrointestinal mucosa, chronic GVHD is defined as a systemic disease with multiorgan involvement, affecting the skin, mouth, genitals, eyes, liver, or lungs, presenting a wide range of signs and symptoms [5,[9][10][11]. Chronic GVHD is associated with increased morbidity and mortality.…”
Section: Introductionmentioning
confidence: 99%
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“…Acute GVHD usually has a limited course, but can be life threatening, while chronic GVHD can require long term treatment with immunosuppressive therapies which in turn place patients at risk of major complications specifically risk of infection. 3 Cutaneous manifestations are the most common sign of GVHD. Individuals suffering from cutaneous GVHD experience a variety of manifestations, including erythematous maculopapular morbilliform eruptions, follicular erythema, erythematous macular and popular rashes erythroderma, itching, dysthesia, sclerotic changes, pain, vulnerability to infection and impact on well-being and quality of life.…”
Section: Introductionmentioning
confidence: 99%