Chronic inflammatory demyelinating polyneuropathy associated with Rickettsia conorii: First case report

Tzanetakos, Dimitrios; Papadopoulou, Maria; Kanellopoulos, D; Mamali, M; Safarikas, M; Katsianos, D; Zisimopoulou, V

doi:10.1016/j.jns.2016.10.015

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another report recommended the coadministration of antiinflammatory agents along with antibiotics during SFR infection [35]. A case of Mediterranean spotted fever (CSF IgG 1:320, IgM 1:10 to R. conorii) in a 63-year-old woman led to chronic inflammatory demyelinating polyneuropathy (CIDP).…”

Section: Sequelae Of Sfr Neurological Infectionmentioning

confidence: 99%

Neuroinflammation associated with scrub typhus and spotted fever group rickettsioses

2020

View full text Add to dashboard Cite

Scrub typhus and spotted fever rickettsioses (SFR) are understudied, vector-borne diseases of global significance. Over 1 billion individuals are at risk for scrub typhus alone in an endemic region, spanning across eastern and southern Asia to Northern Australia. While highly treatable, diagnostic challenges make timely antibiotic intervention difficult for these diseases. Delayed therapy may lead to severe outcomes affecting multiple organs, including the central nervous system (CNS), where infection and associated neuroinflammation may be lethal or lead to lasting sequelae. Meningitis and encephalitis are prevalent in both scrub typhus and SFR. Additionally, case reports detailing focal neurological deficits have come to light, with attention to both acute and chronic sequelae of infection. Despite the increasing number of clinical reports outlining neurologic consequences of these diseases, relatively little research has examined underlying mechanisms of neuroinflammation. Animal models of scrub typhus have identified cerebral T-cell infiltration and vascular damage associated with endothelial infection and neuropathogenesis. Differential gene expression analysis of brain tissues during murine scrub typhus have revealed selective increases in CXCR3 ligands, proinflammatory and type-1 cytokines and chemokines, and cytotoxicity molecules, as well as alterations in the complement pathway. In SFR, microglial expansion and macrophage infiltration contribute to neurological disease progression. This narrative Review highlights clinical neurologic features of scrub typhus and SFR and evaluates our current understanding of basic research into neuroinflammation for both diseases in animal models. Further investigation into key mediators of neuropathogenesis may yield prognostic markers and treatment regimens for severe patients.

show abstract

Section: Sequelae Of Sfr Neurological Infectionmentioning

confidence: 99%

Neuroinflammation associated with scrub typhus and spotted fever group rickettsioses

2020

View full text Add to dashboard Cite

show abstract

“…sanguineus was probably related to the weather conditions, with the mean temperatures being higher than usual with minimal rainfall. Tzanetakos et al reported the first case of a patient with a R. conorii infection who developed acute demyelinating motor sensory neuropathy and showed impaired fine-tune coordination of hand movements and muscle weakness, before being successfully treated with antibiotics [ 71 ].…”

Section: Tick-transmitted Bacteria and Diseases And Associated Tick Speciesmentioning

confidence: 99%

Tick-Borne Pathogens and Diseases in Greece

Efstratiou

Karanis

2021

Microorganisms

View full text Add to dashboard Cite

Tick-borne diseases (TBDs) are recognized as a serious and growing public health epidemic in Europe, and are a cause of major losses in livestock production worldwide. This review is an attempt to present a summary of results from studies conducted over the last century until the end of the year 2020 regarding ticks, tick-borne pathogens, and tick-borne diseases in Greece. We provide an overview of the tick species found in Greece, as well as the most important tick-borne pathogens (viruses, bacteria, protozoa) and corresponding diseases in circulation. We also consider prevalence data, as well as geographic and climatic conditions. Knowledge of past and current situations of TBDs, as well as an awareness of (risk) factors affecting future developments will help to find approaches to integrated tick management as part of the ‘One Health Concept’; it will assist in avoiding the possibility of hotspot disease emergencies and intra- and intercontinental transmission. Increased surveillance in Greece is required to ensure clear and effective policies for TBD control.

show abstract