Chronic Low-grade Inflammation and Haematological, Circulatory, Metabolic, and Hepatic Abnormalities in Childhood Obesity

Abstract

Background: Little is known as to the associations between childhood obesity and chronic low-grade inflammation, circulatory, hepatic, metabolic and haematological abnormalities. Methods and Results: A total of 1,871 boys and 1,810 girls were measured anthropometric data, white blood cell (WBCC), platelet count, blood pressure, plasma concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), and highdensity (HDL) lipoprotein cholesterol,. The subjects were classified into three body mass index categories depending on the international standard definition for child overweight and obesity. WBCC, platelet counts, systolic blood pressure, serum levels of aminotransferases,TG and HDL-cholesterol were related with body composition in both boys and girls. Obese girls had high risks of having abnormal levels of WBCC, platelet count, systolic blood pressure (SBP), ALT, TG, HDL-cholesterol. Obese boys had high risks of having abnormal levels of WBCC, haemobobin concentration, platelet count, SBP, diastolic blood pressure, AST, ALT, TG, and HDL-cholesterol. Conclusions: Childhood obesity is related with chronic inflammation, hypercoagulability, as well as circulatory, metabolic, and hepatic abnormalities.

Anti-Obesity Effect and Action Mechanism ofAdenophora triphyllaRoot Ethanol Extract in C57BL/6 Obese Mice Fed a High-Fat Diet

“…It has been reported that the chronic inflammation state obesity can be caused by oxidative stress generated from the lipid metabolism process when excessive energy intake occures. 30) On hematological analysis, WBCs, including neutrophils and lymphocytes, indicators of inflammation, significantly increased in the C group as compared to the E groups. As no other signs of an inflammation-causing condition were observed, the increases in WBCs might have been linked to the chronic inflammation state obesity of the mice.…”