Chronic nicotine effects on left ventricular function in healthy middle‐aged people: an echocardiographic study

Sundström, Daniel; Waldenborg, Micael; Magnuson, Anders; Emilsson, Kent

doi:10.1111/cpf.12031

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…31 Acute nicotine exposure was also found to cause a significant decrease and delay in relaxation of both right and left ventricles. 32 Studies in healthy subjects have demonstrated acute impairment of LV diastolic function and inducement of a hyperdynamic RV in response to smoking a single cigarette. 33 Smoking is also a risk factor for coronary spasm both in the presence and absence of atherosclerotic coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Smoking intensity and duration is associated with cardiac structure and function: the ECHOcardiographic Study of Hispanics/Latinos

et al. 2017

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ObjectiveCardiovascular disease is the leading cause of death in smokers and this relationship is complicated by the multiplicity of cardiovascular effects of smoking. However, the relationship between intensity and duration of cigarette smoking and echocardiographic measures of right and left ventricular structure and function has been poorly studied.MethodsWe examined ECHO-SOL (Echocardiographic Study of Hispanics/Latinos) participants, a subset of the Hispanic Community Health Study/Study of Latinos. Participants were administered a detailed tobacco exposure questionnaire and a comprehensive echocardiography exam. Multivariable linear regression models (adjusted for age, sex, obesity, hypertension and diabetes statuses) were performed using sampling weights. Statistical significance was defined at p<0.01.ResultsThere were 1818 ECHO-SOL participants (57.4% women, mean age 56.4 years). Among current smokers (n=304), increased duration of smoking, as measured by a younger age of smoking initiation, was significantly associated with higher mean left ventricular mass (LVM) and lower right ventricular (RV) function (lower right ventricular stroke volumes). More cigarettes smoked per day was significantly associated with higher mean LVM, worse diastolic function (higher E/e′ ratio), worse LV geometry (increased relative wall thickness) and worse RV function (decreasing right ventricular stroke volume). Among current smokers, higher mean lifetime pack-years (a combined measure of smoking intensity and duration) was associated with higher LVM, worse LV geometry, worse diastolic function, greater RV dilatation and worse RV function.ConclusionsThere is a dose–response relationship between intensity and duration of cigarette tobacco smoking with unfavourable changes of multiple measures of right-sided and left-sided cardiac structure and function.

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Section: Discussionmentioning

confidence: 99%

Smoking intensity and duration is associated with cardiac structure and function: the ECHOcardiographic Study of Hispanics/Latinos

et al. 2017

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“…In these studies, data on pulmonary function and comprehensive echocardiographic variables were absent. In another much smaller Swedish cohort study with 87 participants, neither heart rate nor ejection fraction could be shown to be influenced by smoking status . Therefore, we believe that this is the first large study reporting significant smoking‐related changes in CI.…”

Section: Discussionmentioning

confidence: 72%

“…Cardiac output indexed for body surface area (cardiac index, CI) is arguably one of the most relevant physiologic parameters of cardiac performance as it encompasses several of the aforementioned components. Previous studies have mainly focused on the acute effects of smoking on systolic and diastolic function, and only a few studies have evaluated the chronic effect of smoking status on echocardiographic variables. So, to date, smoking‐related effects on CI in otherwise healthy subjects are largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic consequences of smoking status in middle‐aged subjects

et al. 2016

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Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation

Conklin

Schick

Blaha

et al. 2019

American Journal of Physiology-Heart and Circulatory Physiology

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Although substantial evidence shows that smoking is positively and robustly associated with cardiovascular disease (CVD), the CVD risk associated with the use of new and emerging tobacco products, such as electronic cigarettes, hookah, and heat-not-burn products, remains unclear. This uncertainty stems from lack of knowledge on how the use of these products affects cardiovascular health. Cardiovascular injury associated with the use of new tobacco products could be evaluated by measuring changes in biomarkers of cardiovascular harm that are sensitive to the use of combustible cigarettes. Such cardiovascular injury could be indexed at several levels. Preclinical changes contributing to the pathogenesis of disease could be monitored by measuring changes in systemic inflammation and oxidative stress, organ-specific dysfunctions could be gauged by measuring endothelial function (flow-mediated dilation), platelet aggregation, and arterial stiffness, and organ-specific injury could be evaluated by measuring endothelial microparticles and platelet-leukocyte aggregates. Classical risk factors, such as blood pressure, circulating lipoproteins, and insulin resistance, provide robust estimates of risk, and subclinical disease progression could be followed by measuring coronary artery Ca2+ and carotid intima-media thickness. Given that several of these biomarkers are well-established predictors of major cardiovascular events, the association of these biomarkers with the use of new and emerging tobacco products could be indicative of both individual and population-level CVD risk associated with the use of these products. Differential effects of tobacco products (conventional vs. new and emerging products) on different indexes of cardiovascular injury could also provide insights into mechanisms by which they induce cardiovascular harm.

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Chronic nicotine effects on left ventricular function in healthy middle‐aged people: an echocardiographic study

Abstract: This study reveals that most systolic- and diastolic cardiac parameters are not chronically significantly altered in middle-aged long-term tobacco users compared with age-matched non-tobacco users.

Cited by 3 publications

References 29 publications

Smoking intensity and duration is associated with cardiac structure and function: the ECHOcardiographic Study of Hispanics/Latinos

Smoking intensity and duration is associated with cardiac structure and function: the ECHOcardiographic Study of Hispanics/Latinos

Echocardiographic consequences of smoking status in middle‐aged subjects

Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation

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