Chronische Uveitiden: Verlauf nach Vitrektomie

Abstract

Vitrectomy is an acknowledged method in the therapy of chronic uveitis and its complications. We analysed the functional results after vitrectomy of 106 patients (121 eyes). In more than 61% of the patients, the visual acuity improved more than one line. There is less glare, and stereoscopic vision is better. In 10% of the patients, the follow-up was complicated by a retinal detachment; in contrast, a primary retinal detachment was the indication for the vitrectomy in 19%. Our study shows that vitrectomy helps reducing the frequency of recurrence of uveitis and the intensity of drug therapy.

Vitrectomy for juvenile uveitis: prognostic factors for the long-term functional outcome

“…These findings compare well with several studies pertaining to vitrectomy in paediatric and adult uveitis which have found a reduction in the recurrence rate and the severity of inflammation with a subsequent reduction of the immunosuppressive need in the postoperative course. 4,5,[9][10][11][12][17][18][19] A possible explanation for these results could be the restoration of an immunological homeostasis by the mechanical removal of the vitreous body with captured autoreactive T cells and proinflammatory cytokines during PPV. 24,25 The replacement of the vitreous with aqueous humor and its numerous immunomodulatory factors after PPV may have an additional regulatory effect.…”

“…There is evidence from numerous studies that PPV can lead to an improvement in visual acuity and reduce CME, and uveitic exacerbations. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] There are only three reports focusing on therapeutic PPV in a paediatric population (in total 43 eyes) with chronic uveitis. [17][18][19] All three groups reported a postoperative improvement in visual acuity, a CME reduction, and reduced rate of recurrences with a subsequently achieved reduction of the immunomodulatory therapy after follow-up times of 6 months to 10 years.…”

25-gauge Vitrectomy for Complicated Chronic Endogenous/Autoimmune Uveitis: Predictors of Outcomes

“…All of them were anecdotal and subjective, however, and had the common shortcomings of a small number of cases, mixture of different disease entities, and short-term follow-up. 2,3,[9][10][11][12][13][14]16,26,27 In our study, VA improvement was gained by 60% of the patients. In another study by our group using sutureless combined 25-gauge vitrectomy, phacoemulsification, and posterior chamber intraocular lens implantation for management of selected patients with uveitic cataract associated with posterior segment disease, final VA was 20/100 in 12 eyes (63.2%) after a minimum of 12 months of follow-up.…”