A 67-year-old Sub-Saharan African man presented to an outside institution with progressive, painless abdominal distention, anorexia, leg swelling, and dyspnea on exertion. He had not seen a physician in many years. He denied alcohol use, intravenous drug use, or any recent surgery. He was referred to our institution for a second opinion. On physical examination, he was alert and orientated. His temperature, pulse, blood pressure, and room air oxygen saturation were 36.1 C, 82 beats per minute, 115/73 mm Hg, and 99%, respectively. He had no purpura and no stigmata of chronic liver disease. He had 3þ pitting edema to the hips and a distended nontense abdomen with shifting dullness. ASSESSMENT Laboratory studies revealed hemoglobin of 13.9 g/dL (ref: 13.9-16.3 g/L), platelet count of 101 K/cu mm (ref: 150-350 K/cu mm), and creatinine of 6.8 mg/dL (ref: 0.6-1.3 mg/dL) (no prior baseline known) corresponding to an estimated glomerular filtration rate (eGFR) of 10 mL/min/1.73m 2 and a serum albumin of 1.4 g/L (ref: 3.5-5.3g/dL). Urinalysis revealed 3þ protein. Urine microscopy demonstrated fatty casts, fine granular casts, and oval fat bodies, but no red or white cell casts. A 24-hour urine collection noted 16.1 g of proteinuria (ref: 0-100 mg/24 h). He had normal liver Funding: None.