Cigarette Smoke-Exposed<i>Candida albicans</i>Increased Chitin Production and Modulated Human Fibroblast Cell Responses

Alanazi, Hanan; Semlali, Abdelhabib; Perraud, Laura; Chmielewski, Witold; Zakrzewski, Andrew; Rouabhia, Mahmoud

doi:10.1155/2014/963156

Cited by 30 publications

(34 citation statements)

References 56 publications

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“…Production of cells located in the basal layer will have high proliferative activity while the degeneration process of the outer layer cells were prevented. These alterations cause epithelial layers to thickened and candida increases its proliferation after being exposed to toxic substances produced from cigarettes [14,16,19,22].…”

Section: Resultsmentioning

confidence: 99%

“…EAP1 gene has an ability to increase candida adhesion towards epithelial cells while Sap gene contributes to the transition of candida from blastopore into hypha [9,22,25]. Hypha formation leads to infection started by the mechanism of hypha entering the epithelial layers and interrupts the process between cells.…”

Section: Advances In Health Science Research Volumementioning

confidence: 99%

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Relationship between Cigarette Smoking and Candida Colony Count in Dental Student at Faculty of Dentistry University of Sumatera Utara

Ramadhani¹,

Nurdiana²,

Astari³

2018

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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Abstract-Cigarette smoking can be described as an activity where a person is enjoying the nicotine smoke produced from the burning tobacco. It contains 4800 chemical substances that are harmful to the body such as nicotine, tar, and carbon monoxide, which then cause changes to the oral cavity. One of the changes is the increase of candida colony count that will lead to abnormal alterations of the oral cavity such as candidiasis. The aim of this study was to find the relationship between cigarette smoking and candida colony count in dental student at Faculty of Dentistry, University of Sumatera Utara using analytic method with cross sectional approach. The study was conducted at Faculty of Dentistry University of Sumatera Utara and Microbiology Laboratory Faculty of Maths and Sciences University of Sumatera Utara on 57 male active smokers. Questionnaire was given to the subjects to gain information about smoking habits and swabs from dorsal of the tongue were examined. The data was statistically analysed using chisquare and p value <0,05 considered as statistically significant. The results showed that subjects were mostly found to be in age group range 17-25 years old. Duration of smoking mostly found was ≥6 years. Number of cigarettes mostly smoked was >10 cigarettes per day. The type of cigarette mostly smoked was filtered-cigarette. Cigarette exposure time mostly found was >15 cigaretteyears. There was a significant relationship between candida colony count and number of cigarettes smoked (p=0,029), but not with duration of smoking (p=0,326). There was also significant relationship between candida colony count and cigarette exposure time (p=0,001), but not with the type of cigarette consumed (p=0,951). The conclusions are both number of cigarettes smoked and cigarette exposure time have significant relationships with candida colony count whereas duration of smoking and type of cigarette did not have significant relationships with candida colony count.

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Section: Resultsmentioning

confidence: 99%

Section: Advances In Health Science Research Volumementioning

confidence: 99%

Relationship between Cigarette Smoking and Candida Colony Count in Dental Student at Faculty of Dentistry University of Sumatera Utara

Ramadhani¹,

Nurdiana²,

Astari³

2018

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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“…Furthermore, C. albicans uses tobacco constituents as nutritional factors, and its virulence factors change accordingly leading to the formation of some chemical compounds [3,4]. Studies investigating the influence of waterpipe smoking on oral mucosa particularly on epithelium are unfortunately scarce.…”

Section: Discussionmentioning

confidence: 99%

“…Candida species becomes an opportunistic pathogen in immunocompromised hosts, causing various systemic, superficial and invasive infections, where C. albicans is considered the most common Candida species causing such infections [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Oral Candida Carriage in Waterpipe and Cigarette Smokers with Various Dietary Habits

Dar‐Odeh

Abu‐Hammad²,

Kutkut³

et al. 2016

Int Arch Med

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Background: Tobacco smoking and diet have been both linked to increased oral Candida carriage. The aim of this study is to investigate the distribution of Candida species in the oral cavity of young individuals smoking cigarettes and waterpipe who have various dietary habits.Methods: Participants were recruited from university students during December 2013, and were divided into three groups; a control nonsmoking, a cigarette smoking, and a waterpipe smoking groups. The study sample completed a pre-structured questionnaire on smoking, and dietary habits. Oral swab samples were collected from all participants to determine oral Candida carriage and the colonizing Candida species. Data were statistically analyzed to determine the significance of association between Candida carriage on one hand and smoking status, and dietary habits on the other hand.Findings: A total of 238 students participated in the study and among those only 30 (12.8%) students had oral Candida carriage. Candida albicans was the most common species to be recovered (56.7%), followed by Candida dubliniensis (23.3%). The association between smoking, and perceived dietary habits on one hand and oral Candida carriage on the other was not statistically significant. Conclusions :Smoking, and perceived dietary habits seem to have no association with oral Candida carriage among a young cohort of university smokers. It is recommended that similar studies are conducted on older age groups to investigate if age has any influence.

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Acellular pericardium: A naturally hierarchical, osteoconductive, and osteoinductive biomaterial for guided bone regeneration

You

Liu

Wang

et al. 2020

J Biomedical Materials Res

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There is great demand for an improved barrier membrane with osteogenic potential for guided bone regeneration (GBR). Natural acellular porcine pericardium (APP) is increasingly used in regenerative medicine as a kind of common extracellular matrix materials. This study aimed to investigate its potential application in GBR, especially its osteoconductive and osteoinductive properties. Bio-Gide (BG), a commercial collagen membrane, was set as the control group. APP samples were characterized by physicochemical analyses and their biological effects on human bone mesenchymal stem cells (hBMSCs) and human gingival fibroblasts (hGFs) were also examined. Additionally, the osteogenic potential of APP was tested on a bilateral critical-sized calvarial defect model. We discovered that the smooth surface of APP tended to recruit more hBMSCs. Moreover, promoted proliferation and osteogenic differentiation of hBMSCs was detected on this side of APP, with increased alkaline phosphatase activity and upregulated expression of bone-specific genes. Besides, the rough side of APP showed good biocompatibility and barrier function with hGFs. Histologic observation and analysis of calvarial defect healing over 4 weeks revealed enhanced bone regeneration under APP compared with BG and the control group. The results of this study indicate that APP is a potential osteoconductive and osteoinductive biomaterial for GBR.

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Cigarette Smoke-ExposedCandida albicansIncreased Chitin Production and Modulated Human Fibroblast Cell Responses

Cited by 30 publications

References 56 publications

Relationship between Cigarette Smoking and Candida Colony Count in Dental Student at Faculty of Dentistry University of Sumatera Utara

Relationship between Cigarette Smoking and Candida Colony Count in Dental Student at Faculty of Dentistry University of Sumatera Utara

Oral Candida Carriage in Waterpipe and Cigarette Smokers with Various Dietary Habits

Acellular pericardium: A naturally hierarchical, osteoconductive, and osteoinductive biomaterial for guided bone regeneration

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