Cigarette smoking in patients with systemic sclerosis reduces overall survival: Comment on the article by Hudson et al

Hissaria, Pravin; Roberts‐Thomson, Peter; Lester, Sue; Ahern, Michael; Smith, Malcolm D.; Walker, Jenny

doi:10.1002/art.30352

Cited by 19 publications

(11 citation statements)

References 10 publications

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“…The female‐to‐male ratio varies between 1.4 to 12.5. Further, the cancer risk for men was higher than women due to smoking . In our study, the female‐to‐male ratio was 1.3 in cancer patients, and there was a history of smoking in patients with lung cancer, neuroendocrine tumor, and myelodysplastic syndrome.…”

Section: Discussionmentioning

confidence: 45%

Systemic sclerosis and malignancy

2018

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Section: Discussionmentioning

confidence: 45%

Systemic sclerosis and malignancy

2018

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“…The risk of cancer was found to be significantly higher in male patients with SSc than in female patients, possibly because of the higher proportion of men who smoke. Studies of 2 large cohorts have shown that smoking was more prevalent among men than women with SSc () as in the general population, and smoking has been proven to increase the risk of Hodgkin's lymphoma and follicular lymphoma, a non‐Hodgkin's lymphoma subtype (), in the general population. We have shown herein that the pooled SIR for hematologic cancer was significantly increased among both men and women with a tendency to be higher among men, and this tendency among male patients may be attributed to smoking in addition to SSc itself.…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence in Systemic Sclerosis: Meta‐Analysis of Population‐Based Cohort Studies

Ōnishi

Sugiyama

Kumagai

et al. 2013

Arthritis & Rheumatism

164

114

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Objective. To examine cancer incidence in patients with systemic sclerosis (SSc) through a meta-analysis of population-based cohort studies.Methods. Five different databases (Medline, Scopus, CINAHL [Cumulative Index to Nursing and Allied Health Literature], Web of Science, and Cochrane Collaboration) were searched for articles published between January 1966 and May 2012; review articles and the reference lists from the articles that resulted from the search were also evaluated. Population-based cohort studies with data relevant to the determination of cancer risk in patients with SSc were included. All articles that met strict inclusion criteria were analyzed for data on population size, time of followup, and observed-to-expected cancer ratios, also known as standardized incidence ratios (SIRs).Results. Six articles met criteria and were included in the meta-analysis. The pooled SIR for the incidence of cancer overall was 1.41 (95% confidence interval [95% CI] 1.18-1.68), and significant heterogeneity was observed as a consequence of variability in the participants, outcome, study design, and risk of bias among the studies. Men had a significantly higher pooled SIR (1.85 [95% CI 1.49-2.31]) than women (SIR 1.33 [95% CI 1.18-1.49]) (P < 0.01), and stratification for sex eliminated heterogeneity, which indicates that variability among the studies greatly contributed to differences between the sexes. There were no differences between limited cutaneous SSc and diffuse cutaneous SSc (P ‫؍‬ 0.77). Significant increases were observed in the risk of cancer of the lung, liver, hematologic system, and bladder, as well as of non-Hodgkin's lymphoma and leukemia.Conclusion. SSc is associated with an increased risk of cancer, particularly lung, liver, hematologic, and bladder cancers, although absolute risk is relatively low. Men with SSc have a higher risk of developing cancer than women.

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“…In a case-control study (621 SSc, 1228 controls), the authors failed to find an association between SSc and smoking status dichotomized into (1) ever smoking (43 vs. 42.5 %) and (2) never smoking (57 vs. 57.5 %) [75]. However, it is established that cigarette smoking results in significant negative effects on vascular and pulmonary outcomes in SSc [76,77].…”

Section: Smoking and Drug Abusementioning

confidence: 99%

Environmental risk factors of systemic sclerosis

Marie

Gehanno

2015

Semin Immunopathol

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Systemic sclerosis (SSc) has a complex pathogenesis. Although, there is a growing evidence that environmental factors have an impact on alterations and modulation of epigenetic determinants, resulting in SSc onset and progression. A marked correlation has thus been found between SSc onset and occupational exposure to crystalline silica and the following organic solvents: white spirit, aromatic solvents, chlorinated solvents, trichloroethylene, and ketones; the risk associated with high cumulative exposure to silica and organic solvents further appears to be strongly increased in SSc. Altogether, occupational exposure should be systematically checked in all SSc patients at diagnosis, as (1) exposed patients seem to develop more severe forms of SSc and (2) the identification of the occupational agents will allow its interruption, which may lead to potential improvement of SSc outcome. By contrast, based on current published data, there is insufficient evidence that exposure to other chemical agents (including notably pesticides as well as personal care such as silicone and hair dye), physical agents (ionizing radiation, ultraviolet radiation, electric and magnetic fields), and biological agents (infections and diet, foods, and dietary contaminants) is a causative factor of SSc. Further investigations are still warranted to identify other environmental factors that may be associated with SSc onset and progression.

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Cigarette smoking in patients with systemic sclerosis reduces overall survival: Comment on the article by Hudson et al

Cited by 19 publications

References 10 publications

Systemic sclerosis and malignancy

Systemic sclerosis and malignancy

Cancer Incidence in Systemic Sclerosis: Meta‐Analysis of Population‐Based Cohort Studies

Environmental risk factors of systemic sclerosis

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