Ciproxifan improves working memory through increased prefrontal cortex neural activity in sleep-restricted mice

Chauveau, Frédéric; Laudereau, K.; Libourel, Paul-Antoine; Gervasoni, Damien; Thomasson, Julien; Poly, B.; Piérard, Christophe; Béracochéa, Daniel

doi:10.1016/j.neuropharm.2014.04.017

Cited by 21 publications

(21 citation statements)

References 70 publications

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“…It has been reported that compounds activating histamine receptors H1 and/or H2 or increasing histamine release (via H3 histamine receptor blockade) substantially improve memory processes . In our study, ciproxifan did not modify spatial memory performance that were already high (around 70%) in control animals, suggesting likely a ceiling effect.…”

Section: Discussioncontrasting

confidence: 52%

“…During the test session, the animals randomly received either the vehicle solution or ciproxifan (3 mg/kg/body weight diluted in a 0.9% saline solution) 30 minutes before behavioral assessment. The dose of ciproxifan was chosen according to previous studies …”

Section: Methodsmentioning

confidence: 99%

“…Ciproxifan (cyclopropyl 4‐(3‐(1H‐imidazol‐4‐yl)propyloxy) phenyl ketone) is an extremely potent histamine H 3 receptor (H 3 R) inverse agonist/antagonist which enhanced the release of histamine and increases sustained attention and alertness states . Both thioperamide (a potent HRH3 antagonist) and ciproxifan enhance working memory and long‐term memory and counteract scopolamine‐induced amnesia …”

Section: Introductionmentioning

confidence: 99%

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Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Chauveau¹,

Job²,

Poly-Thomasson³

et al. 2019

CNS Neurosci Ther

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Summary Aim Although cognitive deficits commonly co‐occur with stress‐related emotional disorders, effect of procognitive drugs such as histaminergic H 3 receptor antagonists are scarcely studied on memory retrieval in stress condition. Methods Experiment 1 . Memory of two successive spatial discriminations (D1 then D2) 24 hours after learning was studied in a four‐hole board in mice. H3 receptor antagonist ciproxifan ( ip 3 mg/kg) and acute stress (three electric footshocks; 0.9 mA; 15 ms) were administered 30 and 15 minutes respectively before memory retrieval test. Fos immunostaining was performed to evaluate the neural activity of several brain areas. Experiment 2 . Effects of ciproxifan and acute stress were evaluated on anxiety‐like behavior in the elevated plus maze and glucocorticoid activity using plasma corticosterone assay. Results Experiment 1 . Ciproxifan increased memory retrieval of D2 in nonstress condition and of D1 in stress one. Ciproxifan mitigated the stress‐induced increase of Fos expression in the prelimbic and infralimbic cortex, the central and basolateral amygdala and the CA1 of dorsal hippocampus. Experiment 2 . Ciproxifan dampened the stress‐induced anxiety‐like behavior and plasma corticosterone increase. Conclusion Ciproxifan improved contextual memory retrieval both in stress and nonstress conditions without exacerbating behavioral and endocrine responses to stress. Overall, these data suggest potential usefulness of H 3 receptor antagonists as cognitive enhancer both in nonstress and stress conditions.

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Section: Discussioncontrasting

confidence: 52%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Chauveau¹,

Job²,

Poly-Thomasson³

et al. 2019

CNS Neurosci Ther

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“…The present survey also revealed volume reduction in the three subdivisions of mPFC. These anatomic changes were correlated to the physiological activity of this region as Chauveau et al (2014[5]) reported that SD decreased the activity of the prelimbic, infralimbic, and cingulate cortices (Chauveau et al, 2014[5]). It has also been approved that the efficient function of mPFC depended on the integrity of the cortex (Leenaars et al, 2012[16]).…”

Section: Discussionmentioning

confidence: 99%

Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

Noorafshan

Karimi

Karbalay‐Doust

et al. 2017

EXCLI Journal; 16:Doc510; ISSN 1611-2156

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“…This timing allows the synthesis of c-fos (early immediate gene) protein in the nuclei of activated neurons (Chauveau et al 2014). Control mice were also anesthetized the fifth day with the same timing as MGT mice.…”

Section: Methodsmentioning

confidence: 99%

Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice

et al. 2016

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One of the hallmarks of decision-making processes is the inter-individual variability between healthy subjects. These behavioral patterns could constitute risk factors for the development of psychiatric disorders. Therefore, finding predictive markers of safe or risky decision-making is an important challenge for psychiatry research. We set up a mouse gambling task (MGT)—adapted from the human Iowa gambling task with uncertain contingencies between response and outcome that furthermore enables the emergence of inter-individual differences. Mice (n = 54) were further individually characterized for locomotive, emotional and cognitive behavior. Individual basal rates of monoamines and brain activation after the MGT were assessed in brain regions related to reward, emotion or cognition. In a large healthy mice population, 44 % showed a balanced strategy with limited risk-taking and flexible choices, 29 % showed a safe but rigid strategy, while 27 % adopted risky behavior. Risky mice took also more risks in other apparatus behavioral devices and were less sensitive to reward. No difference existed between groups regarding anxiety, working memory, locomotion and impulsivity. Safe/rigid mice exhibited a hypoactivation of prefrontal subareas, a high level of serotonin in the orbitofrontal cortex combined with a low level of dopamine in the putamen that predicted the emergence of rigid behavior. By contrast, high levels of dopamine, serotonin and noradrenalin in the hippocampus predicted the emergence of more exploratory and risky behaviors. The coping of C57bl/6J mice in MGT enables the determination of extreme patterns of choices either safe/rigid or risky/flexible, related to specific neurochemical and behavioral markers.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-016-1192-2) contains supplementary material, which is available to authorized users.

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Ciproxifan improves working memory through increased prefrontal cortex neural activity in sleep-restricted mice

Cited by 21 publications

References 70 publications

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice

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Ciproxifan improves working memory through increased prefrontal cortex neural activity in sleep-restricted mice

Cited by 21 publications

References 70 publications

Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress

Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress

Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice

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Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress